Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism. (Q38945539)

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English	Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism.	scientific article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25341043%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

Bortezomib sensitises TRAIL-resistant HPV-positive head and neck cancer cells to TRAIL through a caspase-dependent, E6-independent mechanism (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25341043%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

head and neck cancer

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based on heuristic

inferred from title

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based on heuristic

inferred from title

head and neck carcinoma

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inferred from title

6

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21 February 2020

Selvam Thavaraj

7

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21 February 2020

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J Bullenkamp

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21 February 2020

N Raulf

2

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21 February 2020

B Ayaz

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21 February 2020

H Walczak

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21 February 2020

D Kulms

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21 February 2020

M Tavassoli

8

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21 February 2020

publication date

23 October 2014

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21 February 2020

Cell Death and Disease

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21 February 2020

5

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21 February 2020

e1489

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21 February 2020

copyright license

Creative Commons Attribution 4.0 International

1 October 2014

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April 2022 Public Data File from Crossref

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11 June 2022

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based on heuristic

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TRAIL-R2-specific antibodies and recombinant TRAIL can synergise to kill cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Clinical update on cancer: molecular oncology of head and neck cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Is radiation dose reduction the right answer for HPV-positive head and neck cancer?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Resistance to TRAIL in non-transformed cells is due to multiple redundant pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Targeted therapy of the XIAP/proteasome pathway overcomes TRAIL-resistance in carcinoma by switching apoptosis signaling to a Bax/Bak-independent 'type I' mode

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Bortezomib and TRAIL: a perfect match for apoptotic elimination of tumour cells?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

TRAIL signaling and synergy mechanisms used in TRAIL-based combination therapies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Human Papillomavirus and Rising Oropharyngeal Cancer Incidence in the United States

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9 September 2017

Bortezomib primes glioblastoma, including glioblastoma stem cells, for TRAIL by increasing tBid stability and mitochondrial apoptosis

1 reference

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9 September 2017

Bortezomib primes neuroblastoma cells for TRAIL-induced apoptosis by linking the death receptor to the mitochondrial pathway

1 reference

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9 September 2017

Global cancer statistics

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9 September 2017

A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma

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9 September 2017

Meta-analysis of the impact of human papillomavirus (HPV) on cancer risk and overall survival in head and neck squamous cell carcinomas (HNSCC).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Bortezomib sensitizes human esophageal squamous cell carcinoma cells to TRAIL-mediated apoptosis via activation of both extrinsic and intrinsic apoptosis pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Bortezomib sensitizes human renal cell carcinomas to TRAIL apoptosis through increased activation of caspase-8 in the death-inducing signaling complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

TRAIL and other TRAIL receptor agonists as novel cancer therapeutics

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9 September 2017

The influence of clinical and demographic risk factors on the establishment of head and neck squamous cell carcinoma cell lines

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9 September 2017

Accelerated degradation of FADD and procaspase 8 in cells expressing human papilloma virus 16 E6 impairs TRAIL-mediated apoptosis

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9 September 2017

Bortezomib: proteasome inhibition as an effective anticancer therapy

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9 September 2017

Regulation of apoptosis proteins in cancer cells by ubiquitin

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9 September 2017

TRAIL and apoptosis induction by TNF-family death receptors.

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9 September 2017

Mitochondrial intermembrane proteins in cell death

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9 September 2017

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

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9 September 2017

Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

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9 September 2017

X-linked IAP is a direct inhibitor of cell-death proteases

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9 September 2017

p21 is necessary for the p53-mediated G1 arrest in human cancer cells

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9 September 2017

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

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9 September 2017

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

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9 September 2017

Liberation of functional p53 by proteasome inhibition in human papilloma virus-positive head and neck squamous cell carcinoma cells promotes apoptosis and cell cycle arrest

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Cell cycle-arrested tumor cells exhibit increased sensitivity towards TRAIL-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin

1 reference

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9 September 2017

Human papilloma virus 16 E6 RNA interference enhances cisplatin and death receptor-mediated apoptosis in human cervical carcinoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

9 September 2017

p53-Independent up-regulation of a TRAIL receptor DR5 by proteasome inhibitors: a mechanism for proteasome inhibitor-enhanced TRAIL-induced apoptosis

1 reference

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9 September 2017

Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents.

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14 September 2017

Proteasome inhibitor sensitizes oral squamous cell carcinoma cells to TRAIL-mediated apoptosis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

14 September 2017

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14 September 2017

Radiation response in two HPV-infected head-and-neck cancer cell lines in comparison to a non-HPV-infected cell line and relationship to signaling through AKT.

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14 September 2017

E6 and e7 gene silencing and transformed phenotype of human papillomavirus 16-positive oropharyngeal cancer cells

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14 September 2017

Proteasome inhibitors enhance TRAIL-induced apoptosis through the intronic regulation of DR5: involvement of NF-kappa B and reactive oxygen species-mediated p53 activation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

14 September 2017

Inhibition of nuclear factor-kappaB and target genes during combined therapy with proteasome inhibitor bortezomib and reirradiation in patients with recurrent head-and-neck squamous cell carcinoma

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14 September 2017

Bortezomib abolishes tumor necrosis factor-related apoptosis-inducing ligand resistance via a p21-dependent mechanism in human bladder and prostate cancer cells

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14 September 2017

The proteasome inhibitor bortezomib sensitizes cells to killing by death receptor ligand TRAIL via BH3-only proteins Bik and Bim.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

14 September 2017

X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells

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14 September 2017

Induction of the TRAIL receptor KILLER/DR5 in p53-dependent apoptosis but not growth arrest

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25 September 2017

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17 June 2018

TRAF2 Sets a threshold for extrinsic apoptosis by tagging caspase-8 with a ubiquitin shutoff timer.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

21 August 2018

Sensitization of melanoma cells to TRAIL by UVB-induced and NF-kappaB-mediated downregulation of xIAP.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

21 August 2018

Proteasome inhibitor MG132 sensitizes HPV-positive human cervical cancer cells to rhTRAIL-induced apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

21 August 2018

The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

21 August 2018

FADD is required for multiple signaling events downstream of the receptor Fas.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4649534

21 August 2018

XIAP targeting sensitizes Hodgkin lymphoma cells for cytolytic T-cell attack

1 reference

https://pubmed.ncbi.nlm.nih.gov/25341043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/25341043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I trial using the proteasome inhibitor bortezomib and concurrent chemoradiotherapy for head-and-neck malignancies

1 reference

https://pubmed.ncbi.nlm.nih.gov/25341043

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1038/CDDIS.2014.455

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21 February 2020

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Europe PubMed Central

PMC publication ID

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21 February 2020

PubMed publication ID

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25341043%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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