Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells (Q38925099)

14 June 2018

title

Baicalein upregulates DDIT4 expression which mediates mTOR inhibition and growth inhibition in cancer cells (English)

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14 June 2018

author name string

Yujun Wang

1

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14 June 2018

Ernest Han

2

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14 June 2018

Quanhua Xing

3

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14 June 2018

Jin Yan

4

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14 June 2018

Amanda Arrington

5

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14 June 2018

Charles Wang

6

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14 June 2018

Dylan Tully

7

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14 June 2018

Claudia M Kowolik

8

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14 June 2018

David M Lu

9

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14 June 2018

Paul H Frankel

10

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14 June 2018

Jing Zhai

11

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14 June 2018

Wei Wen

12

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14 June 2018

David Horne

13

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14 June 2018

M L Richard Yip

14

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14 June 2018

John H Yim

15

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14 June 2018

language of work or name

English

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publication date

25 December 2014

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14 June 2018

published in

Cancer Letters

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14 June 2018

volume

358

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14 June 2018

issue

2

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14 June 2018

page(s)

170-179

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14 June 2018

Exploring therapeutic potentials of baicalin and its aglycone baicalein for hematological malignancies

cites work

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Baicalein inhibits the invasion and metastatic capabilities of hepatocellular carcinoma cells via down-regulation of the ERK pathway

17 June 2018

1 reference

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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

17 June 2018

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Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

A phase I study of the chinese herbal medicine PHY906 as a modulator of irinotecan-based chemotherapy in patients with advanced colorectal cancer

17 June 2018

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Identification of a natural compound by cell-based screening that enhances interferon regulatory factor-1 activity and causes tumor suppression

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

A single arm phase II study of a Far-Eastern traditional herbal formulation (sho-sai-ko-to or xiao-chai-hu-tang) in chronic hepatitis C patients.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Baicalein overcomes tumor necrosis factor-related apoptosis-inducing ligand resistance via two different cell-specific pathways in cancer cells but not in normal cells.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

TOR signaling in growth and metabolism

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Role of carrier ligand in platinum resistance of human carcinoma cell lines

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Baicalein induces autophagic cell death through AMPK/ULK1 activation and downregulation of mTORC1 complex components in human cancer cells

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Remarkable synergies between baicalein and tetracycline, and baicalein and beta-lactams against methicillin-resistant Staphylococcus aureus

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Lipoxygenase inhibitors attenuate growth of human pancreatic cancer xenografts and induce apoptosis through the mitochondrial pathway.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5989711

Selective inhibition of platelet lipoxygenase by baicalein

22 August 2018

1 reference

12 December 2020

Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin

1 reference

12 December 2020

Lipoxygenase inhibition induced apoptosis, morphological changes, and carbonic anhydrase expression in human pancreatic cancer cells

1 reference

12 December 2020

Daidzein is a more bioavailable soymilk isoflavone than is genistein in adult women

1 reference

12 December 2020

10.1016/J.CANLET.2014.12.033

Identifiers

DOI

1 reference

14 June 2018

PMCID

5989711

1 reference

14 June 2018

PubMed ID

25543165

1 reference

14 June 2018