Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. (Q38898868)

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English	Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137.	scientific article

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scholarly article

1 reference

Europe PubMed Central

7 September 2017

Mutations in human immunodeficiency virus type 1 integrase confer resistance to the naphthyridine L-870,810 and cross-resistance to the clinical trial drug GS-9137. (English)

1 reference

Europe PubMed Central

7 September 2017

6

object named as

Zeger Debyser

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Barbara Van Remoortel

3

object named as

Barbara Van Remoortel

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5

object named as

Marc De Maeyer

1 reference

Europe PubMed Central

7 September 2017

author name string

Anneleen Hombrouck

1

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Europe PubMed Central

7 September 2017

Arnout Voet

2

1 reference

Europe PubMed Central

7 September 2017

Barbara Van Remoortel

3

1 reference

Europe PubMed Central

7 September 2017

Christel Desadeleer

4

1 reference

Europe PubMed Central

7 September 2017

Myriam Witvrouw

7

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Europe PubMed Central

7 September 2017

language of work or name

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publication date

31 March 2008

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Europe PubMed Central

7 September 2017

Antimicrobial Agents and Chemotherapy

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Europe PubMed Central

7 September 2017

52

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Europe PubMed Central

7 September 2017

6

1 reference

Europe PubMed Central

7 September 2017

2069-2078

1 reference

Europe PubMed Central

7 September 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2415791/fullTextXML

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Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2415791

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Molecular mechanisms of HIV integration and therapeutic intervention

1 reference

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Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA.

1 reference

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The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

1 reference

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A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

1 reference

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Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations

1 reference

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Evidence for "unseen" transposase--DNA contacts

1 reference

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Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes

1 reference

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Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

1 reference

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Assays for the evaluation of HIV-1 integrase inhibitors

1 reference

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HIV-1 integrase inhibitors that compete with the target DNA substrate define a unique strand transfer conformation for integrase

1 reference

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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

1 reference

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Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

1 reference

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Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction

1 reference

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Critical contacts between HIV-1 integrase and viral DNA identified by structure-based analysis and photo-crosslinking

1 reference

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Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

1 reference

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Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.

1 reference

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Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

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Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

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The prevalence of antiretroviral drug resistance in the United States

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An improved PCR-mutagenesis strategy for two-site mutagenesis or sequence swapping between related genes

1 reference

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Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells

1 reference

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Requirement of active human immunodeficiency virus type 1 integrase enzyme for productive infection of human T-lymphoid cells

1 reference

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Synthesis and structure-activity relationships of phenylenebis(methylene)-linked bis-tetraazamacrocycles that inhibit HIV replication. Effects of macrocyclic ring size and substituents on the aromatic linker

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Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360.

1 reference

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Photo-cross-linking studies suggest a model for the architecture of an active human immunodeficiency virus type 1 integrase-DNA complex

1 reference

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Natural polymorphism of the HIV-1 integrase gene and mutations associated with integrase inhibitor resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/18378713

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/AAC.00911-07

1 reference

Europe PubMed Central

7 September 2017

1 reference

Europe PubMed Central

7 September 2017

1 reference

Europe PubMed Central

7 September 2017

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