Targeting the MLL complex in castration-resistant prostate cancer (Q38893281)

7 September 2017

Targeting the MLL complex in castration-resistant prostate cancer (English)

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7 September 2017

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7 September 2017

Nallasivam Palanisamy

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7 September 2017

Alexey I. Nesvizhskii

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7 September 2017

4

Marcin Cieślik

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Dattatreya Mellacheruvu

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Dattatreya Mellacheruvu

20

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Irfan Asangani

object named as

Irfan A Asangani

3

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Saravana M Dhanasekaran

23

object named as

Saravana M Dhanasekaran

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7 September 2017

27

Arul M Chinnaiyan

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7 September 2017

22

Xuhong Cao

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7 September 2017

7

Matthew K Iyer

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7 September 2017

14

Xiaojun Jing

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7 September 2017

6

Xiaoju Wang

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7 September 2017

19

Anastasia K Yocum

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7 September 2017

1

Rohit Malik

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7 September 2017

17

Lakshmi P Kunju

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7 September 2017

24

Felix Y Feng

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7 September 2017

Amjad P Khan

2

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7 September 2017

Xia Jiang

8

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7 September 2017

Dmitry Borkin

9

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7 September 2017

June Escara-Wilke

10

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7 September 2017

Rachell Stender

11

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7 September 2017

Yi-Mi Wu

12

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7 September 2017

Yashar S Niknafs

13

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7 September 2017

Yuanyuan Qiao

15

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7 September 2017

Pranathi M Krishnamurthy

18

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7 September 2017

Jolanta Grembecka

25

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7 September 2017

Tomasz Cierpicki

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7 September 2017

language of work or name

English

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publication date

30 March 2015

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7 September 2017

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21

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7 September 2017

344-352

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7 September 2017

4

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describes a project that uses

7 September 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4390530/fullTextXML

inferred from PubMed Central ID database lookup

limma

1 reference

22 June 2022

https://europepmc.org/article/PMC/4390530

inferred from PubMed Central ID database lookup

exact match

https://scigraph.springernature.com/pub.10.1038/nm.3830

0 references

cites work

Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

limma powers differential expression analyses for RNA-sequencing and microarray studies

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Structure-based design of high-affinity macrocyclic peptidomimetics to block the menin-mixed lineage leukemia 1 (MLL1) protein-protein interaction

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Increased survival with enzalutamide in prostate cancer after chemotherapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

The mutational landscape of lethal castration-resistant prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Abiraterone and increased survival in metastatic prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Disease and host characteristics as predictors of time to first bone metastasis and death in men with progressive castration-resistant nonmetastatic prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

9 September 2017

Global cancer statistics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Castration resistance in human prostate cancer is conferred by a frequently occurring androgen receptor splice variant

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

c-Myb binds MLL through menin in human leukemia cells and is an important driver of MLL-associated leukemogenesis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

MEME SUITE: tools for motif discovery and searching

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Development of a second-generation antiandrogen for treatment of advanced prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

A tissue biomarker panel predicting systemic progression after PSA recurrence post-definitive prostate cancer therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Menin critically links MLL proteins with LEDGF on cancer-associated target genes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Regulation of MLL1 H3K4 methyltransferase activity by its core components

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Identification of the MLL2 complex as a coactivator for estrogen receptor alpha

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

ONCOMINE: a cancer microarray database and integrated data-mining platform

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Molecular determinants of resistance to antiandrogen therapy

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

VCaP, a cell-based model system of human prostate cancer

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Positional cloning of the gene for multiple endocrine neoplasia-type 1

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Reactivation of androgen receptor-regulated TMPRSS2:ERG gene expression in castration-resistant prostate cancer

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Mechanisms of transcriptional regulation by MLL and its disruption in acute leukemia

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

The menin tumor suppressor protein is an essential oncogenic cofactor for MLL-associated leukemogenesis

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Mutation of the androgen-receptor gene in metastatic androgen-independent prostate cancer

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4390530

Menin links estrogen receptor activation to histone H3K4 trimethylation

25 September 2017

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25822367

12 December 2020

inferred from PubMed ID database lookup

Interaction of MLL amino terminal sequences with menin is required for transformation

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25822367

12 December 2020

inferred from PubMed ID database lookup

1 reference

https://pubmed.ncbi.nlm.nih.gov/25822367

12 December 2020

inferred from PubMed ID database lookup

Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer

1 reference

7 January 2021

Sex-determining region Y box 4 is a transforming oncogene in human prostate cancer cells

1 reference

7 January 2021

Integrative molecular concept modeling of prostate cancer progression.

1 reference

7 January 2021

Tumor immunobiological differences in prostate cancer between African-American and European-American men.

1 reference

7 January 2021

Gene expression alterations in prostate cancer predicting tumor aggression and preceding development of malignancy.

1 reference

7 January 2021

Multiclass cancer diagnosis using tumor gene expression signatures

1 reference

7 January 2021

Molecular features of hormone-refractory prostate cancer cells by genome-wide gene expression profiles

1 reference

7 January 2021

Integrative genomic profiling of human prostate cancer

1 reference

7 January 2021

Linear models and empirical bayes methods for assessing differential expression in microarray experiments

1 reference

7 January 2021

Fast and accurate short read alignment with Burrows-Wheeler transform

1 reference

7 January 2021

Model-based analysis of ChIP-Seq (MACS)

1 reference

7 January 2021

The human genome browser at UCSC

1 reference

7 January 2021

HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data

1 reference

7 January 2021

BEDTools: a flexible suite of utilities for comparing genomic features

1 reference

7 January 2021

Java Treeview--extensible visualization of microarray data

1 reference

7 January 2021

Identifiers

DOI

10.1038/NM.3830

1 reference

7 September 2017

1 reference

7 September 2017

1 reference