Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases. (Q38864856)

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14 March 2020

title

Exploring the Influence of Domain Architecture on the Catalytic Function of Diterpene Synthases (English)

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5

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Mengbin Chen

2

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David E. Cane

8

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David W. Christianson

9

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14 March 2020

author name string

Travis A Pemberton

1

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14 March 2020

Wayne K W Chou

4

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Mustafa Köksal

6

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Alex S Genshaft

7

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Golda G Harris

3

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language of work or name

English

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publication date

31 March 2017

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14 March 2020

volume

56

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14 March 2020

page(s)

2010-2023

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issue

14

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Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent-Kaurene Synthases

14 March 2020

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17 June 2018

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Multi-domain terpenoid cyclase architecture and prospects for proximity in bifunctional catalysis

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Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase.

17 June 2018

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Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence

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One amino acid makes the difference: the formation of ent-kaurene and 16α-hydroxy-ent-kaurane by diterpene synthases in poplar

17 June 2018

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Molecular Basis for Stellatic Acid Biosynthesis: A Genome Mining Approach for Discovery of Sesterterpene Synthases

17 June 2018

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17 June 2018

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The first structure of a bacterial diterpene cyclase: CotB2

17 June 2018

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To gibberellins and beyond! Surveying the evolution of (di)terpenoid metabolism

17 June 2018

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Fusicoccin a, a phytotoxic carbotricyclic diterpene glucoside of fungal origin, reduces proliferation and invasion of glioblastoma cells by targeting multiple tyrosine kinases

17 June 2018

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Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus

17 June 2018

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Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis

17 June 2018

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Sesquiterpene synthases: passive catalysts or active players?

17 June 2018

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Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase

17 June 2018

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Taxadiene synthase structure and evolution of modular architecture in terpene biosynthesis

17 June 2018

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Structure of Isoprene Synthase Illuminates the Chemical Mechanism of Teragram Atmospheric Carbon Emission

17 June 2018

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Channeling by Proximity: The Catalytic Advantages of Active Site Colocalization Using Brownian Dynamics

17 June 2018

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Fusicoccin-A selectively induces apoptosis in tumor cells after interferon-alpha priming.

17 June 2018

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Structure of a heterotetrameric geranyl pyrophosphate synthase from mint (Mentha piperita) reveals intersubunit regulation

17 June 2018

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Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates ,

17 June 2018

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Increasing complexity of a diterpene synthase reaction with a single residue switch

17 June 2018

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Functional plasticity of paralogous diterpene synthases involved in conifer defense

17 June 2018

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A single residue switch converts abietadiene synthase into a pimaradiene specific cyclase.

17 June 2018

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Biosynthesis of the earthy odorant geosmin by a bifunctional Streptomyces coelicolor enzyme

17 June 2018

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17 June 2018

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17 June 2018

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Fusicoccins are biosynthesized by an unusual chimera diterpene synthase in fungi

17 June 2018

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17 June 2018

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Alternative termination chemistries utilized by monoterpene cyclases: chimeric analysis of bornyl diphosphate, 1,8-cineole, and sabinene synthases

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PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

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Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis

17 June 2018

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Bornyl diphosphate synthase: structure and strategy for carbocation manipulation by a terpenoid cyclase

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Functional analysis of the two interacting cyclase domains in ent-kaurene synthase from the fungus Phaeosphaeria sp. L487 and a comparison with cyclases from higher plants

17 June 2018

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Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase

17 June 2018

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Structure and function of a squalene cyclase

17 June 2018

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Identifying functional domains within terpene cyclases using a domain-swapping strategy

17 June 2018

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Cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene is the committed step of taxol biosynthesis in Pacific yew

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Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases

17 June 2018

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Purification and characterization of taxa-4(5),11(12)-diene synthase from Pacific yew (Taxus brevifolia) that catalyzes the first committed step of taxol biosynthesis

17 June 2018

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A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome.

17 June 2018

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Stereochemistry of the macrocyclization and elimination steps in taxadiene biosynthesis through deuterium labeling

22 August 2018

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Domain swapping of Citrus limon monoterpene synthases: impact on enzymatic activity and product specificity

22 August 2018

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Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations

22 August 2018

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Heterologous expression and characterization of a "Pseudomature" form of taxadiene synthase involved in paclitaxel (Taxol) biosynthesis and evaluation of a potential intermediate and inhibitors of the multistep diterpene cyclization reaction

22 August 2018

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Transannular proton transfer in the cyclization of geranylgeranyl diphosphate to fusicoccadiene, a biosynthetic intermediate of fusicoccins

22 August 2018

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12 December 2020

Retention index calculation without n-alkanes—the virtual carbon number

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12 December 2020

An Unusual Chimeric Diterpene Synthase from Emericella variecolor and Its Functional Conversion into a Sesterterpene Synthase by Domain Swapping

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12 December 2020

Identification of the single amino acid involved in quenching the ent-kauranyl cation by a water molecule in ent-kaurene synthase of Physcomitrella patens

1 reference

12 December 2020

Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism

1 reference

12 December 2020

Genome Mining for Sesterterpenes Using Bifunctional Terpene Synthases Reveals a Unified Intermediate of Di/Sesterterpenes

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12 December 2020

Non enzymic formation of nerolidol from farnesyl pyrophosphate in the presence of bivalent cations

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12 December 2020

10.1021/ACS.BIOCHEM.7B00137

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14 March 2020

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