Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? (Q38859044)

7 September 2017

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title

Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes? (English)

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metabolic dysfunction–associated steatotic liver disease

7 September 2017

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2

Elisabetta Bugianesi

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7 September 2017

Luca Valenti

1

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PubMed ID

27276701

7 September 2017

Utpal Pajvani

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3

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PubMed ID

27276701

7 September 2017

Giovanni Targher

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4

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7 September 2017

8 June 2016

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7 September 2017

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7 September 2017

36

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7 September 2017

11

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7 September 2017

1563-1579

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Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma.

7 September 2017

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Hepatocellular cancer: the impact of obesity, type 2 diabetes and a multidisciplinary team

21 January 2018

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Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States.

21 January 2018

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Determinants of the association of overweight with elevated serum alanine aminotransferase activity in the United States

21 January 2018

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Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity

21 January 2018

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Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups.

21 January 2018

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Association of nonalcoholic fatty liver disease with insulin resistance.

21 January 2018

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Nonalcoholic fatty liver disease: a feature of the metabolic syndrome

21 January 2018

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Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome

21 January 2018

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Transmembrane 6 superfamily member 2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease.

21 January 2018

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Hepatocellular carcinoma in nonalcoholic fatty liver: role of environmental and genetic factors.

21 January 2018

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Non-alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome

21 January 2018

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Banting lecture 1988. Role of insulin resistance in human disease

21 January 2018

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Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

21 January 2018

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Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

21 January 2018

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Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans: a quantitative study.

21 January 2018

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Higher insulin concentrations are required to suppress gluconeogenesis than glycogenolysis in nondiabetic humans

21 January 2018

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The DGAT2 gene is a candidate for the dissociation between fatty liver and insulin resistance in humans

21 January 2018

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Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men.

21 January 2018

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Insulin resistance in non-diabetic patients with non-alcoholic fatty liver disease: sites and mechanisms

21 January 2018

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Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

21 January 2018

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β-Cell function in type 2 diabetes

21 January 2018

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Sources of fatty acids stored in liver and secreted via lipoproteins in patients with nonalcoholic fatty liver disease

21 January 2018

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Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease

21 January 2018

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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

21 January 2018

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Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects.

21 January 2018

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Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease

21 January 2018

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Role of beta-cell dysfunction, ectopic fat accumulation and insulin resistance in the pathogenesis of type 2 diabetes mellitus

21 January 2018

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Adiponectin and adiponectin receptors

21 January 2018

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Serum total adiponectin in nonalcoholic fatty liver disease: a systematic review and meta-analysis.

21 January 2018

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Adipokines in liver diseases

21 January 2018

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Effect of physiologic hyperinsulinemia on glucose and lipid metabolism in cirrhosis

21 January 2018

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Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients

21 January 2018

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Genetic Factors in the Pathogenesis of Nonalcoholic Fatty Liver and Steatohepatitis

21 January 2018

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The association of fatty liver and diabetes risk

21 January 2018

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Effects of nonalcoholic fatty liver disease on the development of metabolic disorders.

21 January 2018

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Fatty liver is an independent risk factor for the development of Type 2 diabetes in Korean adults

21 January 2018

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Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup

21 January 2018

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Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study

21 January 2018

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Clinical availability of nonalcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in Korean men: 5-year prospective cohort study

21 January 2018

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Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes

21 January 2018

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Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus

21 January 2018

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Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population

21 January 2018

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Resolution of fatty liver and risk of incident diabetes

21 January 2018

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Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes.

21 January 2018

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The impact of non-alcoholic fatty liver disease on incident type 2 diabetes mellitus in non-overweight individuals.

21 January 2018

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Liver fat, statin use, and incident diabetes: The Multi-Ethnic Study of Atherosclerosis

21 January 2018

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Non-alcoholic fatty liver disease predicts type 2 diabetes mellitus, but not prediabetes, in Xi'an, China: a five-year cohort study

21 January 2018

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Comparison of effects of obesity and non-alcoholic fatty liver disease on incidence of type 2 diabetes mellitus

21 January 2018

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Increased risk of type 2 diabetes in subjects with both elevated liver enzymes and ultrasonographically diagnosed nonalcoholic fatty liver disease: a 4-year longitudinal study

21 January 2018

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Nonalcoholic fatty liver disease is associated with an almost twofold increased risk of incident type 2 diabetes and metabolic syndrome. Evidence from a systematic review and meta-analysis.

21 January 2018

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Long-term follow-up of patients with NAFLD and elevated liver enzymes

21 January 2018

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Recent insights into fatty liver, metabolic dyslipidaemia and their links to insulin resistance

21 January 2018

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Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression

21 January 2018

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The role of the lipogenic pathway in the development of hepatic steatosis.

21 January 2018

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

21 January 2018

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mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway

21 January 2018

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SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth

21 January 2018

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The mammalian target of rapamycin regulates lipid metabolism in primary cultures of rat hepatocytes.

21 January 2018

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Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways

21 January 2018

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Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis

21 January 2018

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Critical nodes in signalling pathways: insights into insulin action

21 January 2018

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Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1

21 January 2018

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Hormonal regulation of hepatic glucose production in health and disease

21 January 2018

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The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression

21 January 2018

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Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

21 January 2018

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Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription factor FKHR. Evidence for insulin response unit-dependent and -independent effects of insulin on promoter activity

21 January 2018

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FoxO1 regulates multiple metabolic pathways in the liver: effects on gluconeogenic, glycolytic, and lipogenic gene expression

21 January 2018

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Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

21 January 2018

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Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability

21 January 2018

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Hepatic suppression of Foxo1 and Foxo3 causes hypoglycemia and hyperlipidemia in mice

21 January 2018

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Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene

21 January 2018

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Integrated control of hepatic lipogenesis versus glucose production requires FoxO transcription factors.

21 January 2018

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Hepatic autophagy is suppressed in the presence of insulin resistance and hyperinsulinemia: inhibition of FoxO1-dependent expression of key autophagy genes by insulin

21 January 2018

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S 50131 and S 51434, two novel small molecule glucokinase activators, lack chronic efficacy despite potent acute antihyperglycaemic activity in diabetic mice

21 January 2018

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Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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New insights into mTOR signaling: mTORC2 and beyond

21 January 2018

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PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth

21 January 2018

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

21 January 2018

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Turning off AKT: PHLPP as a drug target

21 January 2018

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PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice

21 January 2018

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Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and PH domain and leucine-rich repeat phosphatase cross-talk (PHLPP) in cancer cells and in transforming growth factor β-activated stem cells

21 January 2018

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Both decreased and increased SRPK1 levels promote cancer by interfering with PHLPP-mediated dephosphorylation of Akt.

21 January 2018

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mTORC1-independent Raptor prevents hepatic steatosis by stabilizing PHLPP2.

21 January 2018

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Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma.

21 January 2018

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SCD1 Expression is dispensable for hepatocarcinogenesis induced by AKT and Ras oncogenes in mice

21 January 2018

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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

21 January 2018

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The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis

21 January 2018

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Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

21 January 2018

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Pathogenesis of selective insulin resistance in isolated hepatocytes

21 January 2018

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Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet

21 January 2018

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Increased insulin receptor substrate 2 expression is associated with steatohepatitis and altered lipid metabolism in obese subjects.

21 January 2018

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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

21 January 2018

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Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease.

21 January 2018

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CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance

21 January 2018

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Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids

21 January 2018

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Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver

21 January 2018

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SREBP-1c mediates the insulin-dependent hepatic glucokinase expression.

21 January 2018

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Hepatic glucokinase expression is associated with lipogenesis and fatty liver in humans.

21 January 2018

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Hepatic notch signaling correlates with insulin resistance and nonalcoholic fatty liver disease.

21 January 2018

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Genetics of nonalcoholic fatty liver disease.

21 January 2018

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Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

21 January 2018

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Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease

21 January 2018

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PNPLA3 I148M polymorphism and progressive liver disease

21 January 2018

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A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

21 January 2018

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PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells

21 January 2018

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PNPLA3 mediates hepatocyte triacylglycerol remodeling

21 January 2018

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Pnpla3I148M knockin mice accumulate PNPLA3 on lipid droplets and develop hepatic steatosis

21 January 2018

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The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage.

21 January 2018

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Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity

21 January 2018

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Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant

21 January 2018

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Exome-wide association study identifies a TM6SF2 variant that confers susceptibility to nonalcoholic fatty liver disease

21 January 2018

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TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content

21 January 2018

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Systematic evaluation of coding variation identifies a candidate causal variant in TM6SF2 influencing total cholesterol and myocardial infarction risk

21 January 2018

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Inactivation of Tm6sf2, a Gene Defective in Fatty Liver Disease, Impairs Lipidation but Not Secretion of Very Low Density Lipoproteins

21 January 2018

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The dual and opposite role of the TM6SF2-rs58542926 variant in protecting against cardiovascular disease and conferring risk for nonalcoholic fatty liver: A meta-analysis

21 January 2018

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The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent

21 January 2018

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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits

21 January 2018

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Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents

21 January 2018

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Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease

21 January 2018

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The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

21 January 2018

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A novel APOB mutation identified by exome sequencing cosegregates with steatosis, liver cancer, and hypocholesterolemia

21 January 2018

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Dissociation between intrahepatic triglyceride content and insulin resistance in familial hypobetalipoproteinemia

21 January 2018

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Genetic variants regulating insulin receptor signalling are associated with the severity of liver damage in patients with non-alcoholic fatty liver disease.

21 January 2018

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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

21 January 2018

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

21 January 2018

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Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

21 January 2018

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Unraveling the genetics of fatty liver in obese children: Additive effect of P446L GCKR and I148M PNPLA3 polymorphisms

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/LIV.13185

1 reference

7 September 2017

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PubMed ID

27276701