Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells (Q38835914)

6 September 2017

Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells (English)

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6 September 2017

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Ming-Chang Chiang

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6 September 2017

Yi-Chuan Cheng

2

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6 September 2017

Christopher J Nicol

3

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6 September 2017

Kuan-Hung Lin

4

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6 September 2017

Chia-Hui Yen

5

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6 September 2017

Shiang-Jiuun Chen

6

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6 September 2017

Rong-Nan Huang

7

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6 September 2017

language of work or name

English

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publication date

8 September 2015

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Experimental Cell Research

6 September 2017

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6 September 2017

338

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6 September 2017

2

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6 September 2017

183-193

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Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

6 September 2017

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Huntington's disease. Pathogenesis and management

7 January 2021

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Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation

7 January 2021

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Recent advances in understanding the pathogenesis of Huntington's disease

7 January 2021

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Protein aggregates in Huntington's disease.

7 January 2021

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Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

7 January 2021

1 reference

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Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression

7 January 2021

1 reference

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Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

7 January 2021

1 reference

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The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system

7 January 2021

1 reference

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Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease

7 January 2021

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Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases

7 January 2021

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Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

7 January 2021

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ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

7 January 2021

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Obesity and the regulation of energy balance

7 January 2021

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PPAR gamma, 10 years later

7 January 2021

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The many faces of PPARgamma

7 January 2021

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PPAR: a new pharmacological target for neuroprotection in stroke and neurodegenerative diseases

7 January 2021

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PPARgamma as a therapeutic target in central nervous system diseases

7 January 2021

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PPARgamma agonists as new therapeutic agents for the treatment of Alzheimer's disease

7 January 2021

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Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease

7 January 2021

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Rosiglitazone treatment prevents mitochondrial dysfunction in mutant huntingtin-expressing cells: possible role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in the pathogenesis of Huntington disease

7 January 2021

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Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

7 January 2021

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The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease

7 January 2021

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PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.

7 January 2021

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cAMP-response element-binding protein contributes to suppression of the A2A adenosine receptor promoter by mutant Huntingtin with expanded polyglutamine residues

7 January 2021

1 reference

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β-adrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system

7 January 2021

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Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway

7 January 2021

1 reference

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Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease

7 January 2021

1 reference

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Systematic uncovering of multiple pathways underlying the pathology of Huntington disease by an acid-cleavable isotope-coded affinity tag approach

7 January 2021

1 reference

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PPARγ regulates the mitochondrial dysfunction in human neural stem cells with tumor necrosis factor alpha

7 January 2021

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The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent.

7 January 2021

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Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.

7 January 2021

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Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator

7 January 2021

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Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin

7 January 2021

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Examining the safety of PPAR agonists - current trends and future prospects

7 January 2021

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Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists.

7 January 2021

1 reference

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Peroxisome Proliferator-Activated Receptor-gamma in Amyotrophic Lateral Sclerosis and Huntington's Disease

7 January 2021

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Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases.

7 January 2021

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Atypical diabetes associated with inclusion formation in the R6/2 mouse model of Huntington's disease is not improved by treatment with hypoglycaemic agents.

7 January 2021

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Pioglitazone ameliorates behavioral, biochemical and cellular alterations in quinolinic acid induced neurotoxicity: possible role of peroxisome proliferator activated receptor-Upsilon (PPARUpsilon) in Huntington's disease

7 January 2021

1 reference

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Protective effect of pioglitazone, a PPARγ ligand, in a 3 nitropropionic acid model of Huntington's disease

7 January 2021

1 reference

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Metabolic state determines sensitivity to cellular stress in Huntington disease: normalization by activation of PPARγ.

7 January 2021

1 reference

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The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

7 January 2021

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PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington's disease to Parkinson's disease and beyond

7 January 2021

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Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases

7 January 2021

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Proteasomes: machines for all reasons

7 January 2021

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Proteostasis and neurodegeneration: the roles of proteasomal degradation and autophagy

7 January 2021

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Illuminating the ubiquitin/proteasome system

7 January 2021

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Impairment of the ubiquitin-proteasome system by protein aggregation

7 January 2021

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The ubiquitin-proteasome pathway in health and disease of the nervous system

7 January 2021

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Regulation of proteasome activity in health and disease

7 January 2021

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Global changes to the ubiquitin system in Huntington's disease.

7 January 2021

1 reference

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Impaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice

7 January 2021

1 reference

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Is the ubiquitin-proteasome system impaired in Huntington's disease?

7 January 2021

1 reference

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Ubiquitin ligase Hrd1 enhances the degradation and suppresses the toxicity of polyglutamine-expanded huntingtin

7 January 2021

1 reference

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Gene expression profiling of potential PPARgamma target genes in mouse aorta

7 January 2021

1 reference

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Hsp70 chaperones: cellular functions and molecular mechanism

7 January 2021

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To be, or not to be--molecular chaperones in protein degradation

7 January 2021

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Progressive decrease in chaperone protein levels in a mouse model of Huntington's disease and induction of stress proteins as a therapeutic approach

7 January 2021

1 reference

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Modulation of polyglutamine inclusion formation by the Hsp70 chaperone machine.

7 January 2021

1 reference

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Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington's disease

7 January 2021

1 reference

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Neuroprotection by Hsp104 and Hsp27 in lentiviral-based rat models of Huntington's disease

7 January 2021

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Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer

7 January 2021

1 reference

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Roles of Hsp104 and trehalose in solubilisation of mutant huntingtin in heat shocked Saccharomyces cerevisiae cells

7 January 2021

1 reference

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Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models

7 January 2021

1 reference

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Thiazolidinedione class of peroxisome proliferator-activated receptor gamma agonists prevents neuronal damage, motor dysfunction, myelin loss, neuropathic pain, and inflammation after spinal cord injury in adult rats

7 January 2021

1 reference

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ER stress and neurodegenerative diseases

7 January 2021

1 reference

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Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease

7 January 2021

1 reference

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Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

7 January 2021

1 reference

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Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway

7 January 2021

1 reference

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Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c release

7 January 2021

1 reference

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Intranuclear huntingtin increases the expression of caspase-1 and induces apoptosis

7 January 2021

1 reference

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Inhibitors of metabolism rescue cell death in Huntington's disease models.

7 January 2021

1 reference

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Mutant huntingtin causes context-dependent neurodegeneration in mice with Huntington's disease.

7 January 2021

1 reference

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Peroxisome proliferator-activated receptor gamma up-regulates the Bcl-2 anti-apoptotic protein in neurons and induces mitochondrial stabilization and protection against oxidative stress and apoptosis.

7 January 2021

1 reference

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Neuropathological classification of Huntington's disease

7 January 2021

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/J.YEXCR.2015.09.005

1 reference

6 September 2017

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