Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells. (Q38804189)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28472268%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

title

Nickel induces transcriptional down-regulation of DNA repair pathways in tumorigenic and non-tumorigenic lung cells (English)

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19 March 2020

5

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19 March 2020

author name string

Susan E Scanlon

1

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19 March 2020

Christine D Scanlon

2

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19 March 2020

Denise C Hegan

3

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19 March 2020

Parker L Sulkowski

4

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19 March 2020

language of work or name

English

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publication date

1 June 2017

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19 March 2020

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19 March 2020

volume

38

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19 March 2020

issue

6

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19 March 2020

page(s)

627-637

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Metal binding mediated conformational change of XPA protein:a potential cytotoxic mechanism of nickel in the nucleotide excision repair

19 March 2020

cites work

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miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair

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Histone Methylation in Nickel-Smelting Industrial Workers

22 June 2018

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22 June 2018

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22 June 2018

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Inorganic Arsenic-induced cellular transformation is coupled with genome wide changes in chromatin structure, transcriptome and splicing patterns

22 June 2018

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Epigenetic dysregulation by nickel through repressive chromatin domain disruption

22 June 2018

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The BRAF oncoprotein functions through the transcriptional repressor MAFG to mediate the CpG Island Methylator phenotype

22 June 2018

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Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair

22 June 2018

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Silencing of the DNA mismatch repair gene MLH1 induced by hypoxic stress in a pathway dependent on the histone demethylase LSD1

22 June 2018

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Hypoxia provokes base excision repair changes and a repair-deficient, mutator phenotype in colorectal cancer cells

22 June 2018

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Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.

22 June 2018

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Arsenic induces the expressions of angiogenesis-related factors through PI3K and MAPK pathways in SV-HUC-1 human uroepithelial cells

22 June 2018

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Chronic exposure to arsenic, estrogen, and their combination causes increased growth and transformation in human prostate epithelial cells potentially by hypermethylation-mediated silencing of MLH1.

22 June 2018

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Aberrant overexpression of FOXM1 transcription factor plays a critical role in lung carcinogenesis induced by low doses of arsenic

22 June 2018

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Gene expression profiles in peripheral blood mononuclear cells of Chinese nickel refinery workers with high exposures to nickel and control subjects

22 June 2018

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Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype

22 June 2018

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β-catenin involvement in arsenite-induced VEGF expression in neuroblastoma SH-SY5Y cells

22 June 2018

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The control of histone methylation and gene expression by oxidative stress, hypoxia, and metals

22 June 2018

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The effect of exposure to carcinogenic metals on histone tail modifications and gene expression in human subjects

22 June 2018

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Carcinogenic metals and the epigenome: understanding the effect of nickel, arsenic, and chromium

22 June 2018

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Global levels of histone modifications in peripheral blood mononuclear cells of subjects with exposure to nickel

22 June 2018

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Role and mechanism of arsenic in regulating angiogenesis

22 June 2018

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Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter

22 June 2018

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Factors determining DNA double-strand break repair pathway choice in G2 phase

22 June 2018

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Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells

22 June 2018

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Nickel ions inhibit histone demethylase JMJD1A and DNA repair enzyme ABH2 by replacing the ferrous iron in the catalytic centers

22 June 2018

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Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes

22 June 2018

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ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

22 June 2018

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Modulation of histone methylation and MLH1 gene silencing by hexavalent chromium

22 June 2018

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Effects of nickel, chromate, and arsenite on histone 3 lysine methylation

22 June 2018

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Iron- and 2-oxoglutarate-dependent dioxygenases: an emerging group of molecular targets for nickel toxicity and carcinogenicity

22 June 2018

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Inhibition of poly(ADP-ribose) polymerase-1 by arsenite interferes with repair of oxidative DNA damage

22 June 2018

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Radiosensitization of yeast cells by inhibition of histone h4 acetylation

22 June 2018

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Arsenite alters global histone H3 methylation

22 June 2018

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Hypoxia induces a novel signature of chromatin modifications and global repression of transcription

22 June 2018

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Epigenetic silencing of O6-methylguanine DNA methyltransferase gene in NiS-transformed cells

22 June 2018

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Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium

22 June 2018

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Co-repression of mismatch repair gene expression by hypoxia in cancer cells: role of the Myc/Max network

22 June 2018

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Trace elements and cancer risk: a review of the epidemiologic evidence

22 June 2018

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Repression of RAD51 gene expression by E2F4/p130 complexes in hypoxia

22 June 2018

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Soluble nickel inhibits HIF-prolyl-hydroxylases creating persistent hypoxic signaling in A549 cells

22 June 2018

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Nickel ions increase histone H3 lysine 9 dimethylation and induce transgene silencing

22 June 2018

1 reference

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Alterations of histone modifications and transgene silencing by nickel chloride

22 June 2018

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Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1alpha) and HIF-regulated genes.

22 June 2018

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Hypoxia-induced down-regulation of BRCA1 expression by E2Fs.

22 June 2018

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Carcinogenic effect of nickel compounds

22 June 2018

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Nickel carcinogenesis: epigenetics and hypoxia signaling

22 June 2018

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Arsenite induces HIF-1a and VEGF through PI3K, Akt and reactive oxygen species in DU145 human prostate carcinoma cells

22 June 2018

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Nickel (II) enhances benzo[a]pyrene diol epoxide-induced mutagenesis through inhibition of nucleotide excision repair in human cells: a possible mechanism for nickel (II)-induced carcinogenesis

22 June 2018

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Genomic and proteomic profiling of responses to toxic metals in human lung cells

22 June 2018

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Interference by toxic metal ions with DNA repair processes and cell cycle control: molecular mechanisms

22 June 2018

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Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite

22 June 2018

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Carcinogenic nickel induces genes involved with hypoxic stress

22 June 2018

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Nickel(II) increases the sensitivity of V79 Chinese hamster cells towards cisplatin and transplatin by interference with distinct steps of DNA repair

22 June 2018

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Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: a model for a mechanism of carcinogenesis.

22 June 2018

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Exposure to nickel compounds and smoking in relation to incidence of lung and nasal cancer among nickel refinery workers

22 June 2018

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Hypoxia causes epigenetic gene regulation in macrophages by attenuating Jumonji histone demethylase activity.

22 June 2018

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Signaling pathways for arsenic-stimulated vascular endothelial growth factor-a expression in primary vascular smooth muscle cells

31 August 2018

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Nickel impairs the repair of UV- and MNNG-damaged DNA.

31 August 2018

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GeneChip analysis of signaling pathways effected by nickel

31 August 2018

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Evidence for a role of p38 kinase in hypoxia-inducible factor 1-independent induction of vascular endothelial growth factor expression by sodium arsenite

31 August 2018

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Nickel(II) interferes with the incision step in nucleotide excision repair in mammalian cells.

31 August 2018

1 reference

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Chronic oral exposure to inorganic arsenate interferes with methylation status of p16INK4a and RASSF1A and induces lung cancer in A/J mice

31 August 2018

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12 December 2020

Inhibition of repair of radiation-induced DNA double-strand breaks by nickel and arsenite

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12 December 2020

Nickel compounds and metallic nickel

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12 December 2020

Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers

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12 December 2020

Microsatellite instability and protein expression of the DNA mismatch repair gene, hMLH1, of lung cancer in chromate-exposed workers

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12 December 2020

Identifiers

DOI

10.1093/CARCIN/BGX038

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28472268%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28472268%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

PubMed publication ID

28472268

1 reference