Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate (Q38784214)

6 September 2017

Structure and reactivity of Trypanosoma brucei pteridine reductase: inhibition by the archetypal antifolate methotrexate (English)

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6 September 2017

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pteridine reductase 1

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6 February 2019

7

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6 September 2017

Lindsay B Tulloch

4

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Natasha Sienkiewicz

3

object named as

Natasha Sienkiewicz

1 reference

6 September 2017

Alice Dawson

1

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6 September 2017

Federica Gibellini

2

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6 September 2017

Paul K Fyfe

5

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6 September 2017

Karen McLuskey

6

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6 September 2017

William N Hunter

8

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6 September 2017

language of work or name

English

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publication date

1 September 2006

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6 September 2017

Molecular Microbiology

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6 September 2017

61

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6 September 2017

6

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6 September 2017

1457-1468

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Proteases universally recognize beta strands in their active sites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

DNA and RNA synthesis: antifolates

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Coot: model-building tools for molecular graphics

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Refinement of macromolecular structures by the maximum-likelihood method

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

The CCP4 suite: programs for protein crystallography

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Tethering: fragment-based drug discovery

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Structure, dynamics, and catalytic function of dihydrofolate reductase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Chemotherapy of human African trypanosomiasis: current and future prospects

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Antimalarial compounds: from bench to bedside

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Structure of pteridine reductase (PTR1) from Leishmania tarentolae

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Short-chain dehydrogenases/reductases (SDR): the 2002 update

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Pteridine reductase mechanism correlates pterin metabolism with drug resistance in trypanosomatid parasites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

An approach to multi-copy search in molecular replacement

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

ESPript: analysis of multiple sequence alignments in PostScript

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Remarks about protein structure precision

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

The roles of pteridine reductase 1 and dihydrofolate reductase-thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Loop and subdomain movements in the mechanism of Escherichia coli dihydrofolate reductase: crystallographic evidence

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

PTR1: a reductase mediating salvage of oxidized pteridines and methotrexate resistance in the protozoan parasite Leishmania major.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Eukaryotic dihydrofolate reductase

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

A pteridine reductase gene ptr1 contiguous to a P-glycoprotein confers resistance to antifolates in Trypanosoma cruzi.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

New approaches to Leishmania chemotherapy: pteridine reductase 1 (PTR1) as a target and modulator of antifolate sensitivity.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Selective inhibition of Leishmania dihydrofolate reductase and Leishmania growth by 5-benzyl-2,4-diaminopyrimidines

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Nutritional requirements of wild-type and folate transport-deficient Leishmania donovani for pterins and folates

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1618733

Rational proteomics I. Fingerprint identification and cofactor specificity in the short-chain oxidoreductase (SCOR) enzyme family.

23 June 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

Structure of and kinetic channelling in bifunctional dihydrofolate reductase-thymidylate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

Inhibition of Leishmania major pteridine reductase by 2,4,6-triaminoquinazoline: structure of the NADPH ternary complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

Processing of X-ray diffraction data collected in oscillation mode

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

Dihydrofolate reductases within the genus Trypanosoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2958.2006.05332.X

The growth and nutrition of Crithidia fasciculata

21 January 2018

1 reference

12 December 2020

Do C-H...O hydrogen bonds contribute to the stability of nucleic acid base pairs?

1 reference

12 December 2020

Dihydrofolate reductase. The stereochemistry of inhibitor selectivity

1 reference

12 December 2020

Biochemical and genetic tests for inhibitors of Leishmania pteridine pathways

1 reference

12 December 2020

Leishmania major pteridine reductase 1 belongs to the short chain dehydrogenase family: stereochemical and kinetic evidence

1 reference

12 December 2020

10.1111/J.1365-2958.2006.05332.X

Identifiers

DOI

1 reference

6 September 2017

1 reference

6 September 2017

PubMed publication ID

16968221

1 reference