In Vivo and In Vitro Evidence for Brain Uptake of 4-Phenylbutyrate by the Monocarboxylate Transporter 1 (MCT1). (Q38782500)

6 September 2017

In Vivo and In Vitro Evidence for Brain Uptake of 4-Phenylbutyrate by the Monocarboxylate Transporter 1 (MCT1). (English)

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6 September 2017

Na-Young Lee

1

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PubMed ID

27026010

6 September 2017

Young-Sook Kang

series ordinal

2

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6 September 2017

29 March 2016

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6 September 2017

Pharmaceutical Research

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6 September 2017

33

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6 September 2017

7

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6 September 2017

1711-1722

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Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.

6 September 2017

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Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy

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Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency

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Chemical chaperones: a pharmacological strategy for disorders of protein folding and trafficking

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Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress

21 January 2018

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Neuroprotective effects of phenylbutyrate against MPTP neurotoxicity.

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Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease

21 January 2018

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Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease

21 January 2018

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Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

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Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer´s disease-like phenotype of a commonly used mouse model.

21 January 2018

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Blood-brain barrier transporters and response to CNS-active drugs

21 January 2018

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GHB (gamma-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier

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Transport of valproate at intestinal epithelial (Caco-2) and brain endothelial (RBE4) cells: mechanism and substrate specificity

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The brain-to-blood efflux transport of taurine and changes in the blood-brain barrier transport system by tumor necrosis factor-alpha

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mRna expression and transport characterization of conditionally immortalized rat brain capillary endothelial cell lines; a new in vitro BBB model for drug targeting

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Regulation of taurine transport at the blood-brain barrier by tumor necrosis factor-alpha, taurine and hypertonicity

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The acetylcholinesterase inhibitors competitively inhibited an acetyl L-carnitine transport through the blood-brain barrier

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The SLC16 gene family - structure, role and regulation in health and disease

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Sodium 4-phenylbutyrate protects against cerebral ischemic injury.

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Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice

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Pharmacokinetics and cerebrospinal fluid penetration of phenylacetate and phenylbutyrate in the nonhuman primate

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Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain

21 January 2018

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New approaches to in vitro models of blood-brain barrier drug transport.

21 January 2018

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Brain uptake of the drug of abuse γ-hydroxybutyric acid in rats

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Monocarboxylate transport in erythrocytes

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γ-Hydroxybutyrate blood/plasma partitioning: effect of physiologic pH on transport by monocarboxylate transporters

21 January 2018

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Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters

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Predominant contribution of organic anion transporting polypeptide OATP-B (OATP2B1) to apical uptake of estrone-3-sulfate by human intestinal Caco-2 cells.

21 January 2018

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Modulation of monocarboxylic acid transporter-1 kinetic function by the cAMP signaling pathway in rat brain endothelial cells

21 January 2018

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ABC and SLC transporter expression and proton oligopeptide transporter (POT) mediated permeation across the human blood--brain barrier cell line, hCMEC/D3 [corrected]

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pH-dependent and carrier-mediated transport of salicylic acid across Caco-2 cells

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Role of monocarboxylate transporters in drug delivery to the brain

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Identity of SMCT1 (SLC5A8) as a neuron-specific Na+-coupled transporter for active uptake of L-lactate and ketone bodies in the brain

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Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of DeltaF508-CFTR

21 January 2018

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12 December 2020

Taurine transport mechanism through the blood-brain barrier in spontaneously hypertensive rats

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12 December 2020

Monocarboxylate transporters in the central nervous system: distribution, regulation and function.

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Developing a new formulation of sodium phenylbutyrate

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12 December 2020

Quantitative atlas of membrane transporter proteins: development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria

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12 December 2020

Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.

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12 December 2020

Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1

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12 December 2020

Pharmacokinetics, placenta, and brain uptake of paclitaxel in pregnant rats

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12 December 2020

10.1007/S11095-016-1912-6

Identifiers

DOI

1 reference

6 September 2017

1 reference

PubMed ID

27026010