Bcl-2 proteins and calcium signaling: complexity beneath the surface (Q38773462)

6 September 2017

Bcl-2 proteins and calcium signaling: complexity beneath the surface (English)

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6 September 2017

2

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6 September 2017

T Vervliet

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6 September 2017

G Bultynck

series ordinal

3

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6 September 2017

language of work or name

English

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publication date

14 March 2016

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6 September 2017

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6 September 2017

35

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6 September 2017

5079-5092

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6 September 2017

39

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https://scigraph.springernature.com/pub.10.1038/onc.2016.31

6 September 2017

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Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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Bcl-2 protein family members: versatile regulators of calcium signaling in cell survival and apoptosis

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Mitochondrial Ca(2+) signals in autophagy.

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Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

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The ER-mitochondria interface: the social network of cell death

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The mitochondrial permeability transition pore and cancer: molecular mechanisms involved in cell death

21 January 2018

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VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria.

21 January 2018

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Mitochondrial Ca(2+) influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

21 January 2018

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Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD

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Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

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TRPV6 calcium channel translocates to the plasma membrane via Orai1-mediated mechanism and controls cancer cell survival

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TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.

21 January 2018

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Calcium in tumour metastasis: new roles for known actors.

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Orai1 and STIM1 are critical for breast tumor cell migration and metastasis

21 January 2018

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ORAI1-mediated calcium influx in lactation and in breast cancer

21 January 2018

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Novel frontiers in calcium signaling: A possible target for chemotherapy

21 January 2018

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Calcium and cancer: targeting Ca2+ transport

21 January 2018

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Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

21 January 2018

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The BRCA1 tumor suppressor binds to inositol 1,4,5-trisphosphate receptors to stimulate apoptotic calcium release.

21 January 2018

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Mitochondria associated membranes (MAMs) as critical hubs for apoptosis

21 January 2018

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Remodeling of channel-forming ORAI proteins determines an oncogenic switch in prostate cancer

21 January 2018

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Functional SNP in the microRNA-367 binding site in the 3'UTR of the calcium channel ryanodine receptor gene 3 (RYR3) affects breast cancer risk and calcification

21 January 2018

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Calcium channels and pumps in cancer: changes and consequences

21 January 2018

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Bcl-2 family proteins and cancer

21 January 2018

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Apoptosis and oncogenesis: give and take in the BCL-2 family

21 January 2018

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Bcl-2 and calcium: controversy beneath the surface

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Control of mitochondrial apoptosis by the Bcl-2 family

21 January 2018

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Mitochondria and cell death: outer membrane permeabilization and beyond

21 January 2018

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How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

21 January 2018

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21 January 2018

The BCL-2 family reunion

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Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

21 January 2018

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Mitochondrial membrane permeabilization in cell death

21 January 2018

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Targeting the B-cell lymphoma/leukemia 2 family in cancer

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

An inhibitor of Bcl-2 family proteins induces regression of solid tumours

21 January 2018

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Antiapoptotic potency of Bcl-2 proteins primarily relies on their stability, not binding selectivity.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

NH2-terminal BH4 domain of Bcl-2 is functional for heterodimerization with Bax and inhibition of apoptosis

21 January 2018

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The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Small-Molecule Bcl2 BH4 Antagonist for Lung Cancer Therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

A dual role for the anti-apoptotic Bcl-2 protein in cancer: mitochondria versus endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Endoplasmic reticulum localized Bcl-2 prevents apoptosis when redistribution of cytochrome c is a late event

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2 on the endoplasmic reticulum regulates Bax activity by binding to BH3-only proteins

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Intracellular localization of the BCL-2 family member BOK and functional implications

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Characterization of the signal that directs Bcl-x(L), but not Bcl-2, to the mitochondrial outer membrane

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Evidence that BCL-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca2+ fluxes

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2 overexpression abolishes early calcium waving preceding apoptosis in NIH-3T3 murine fibroblasts

21 January 2018

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Mitochondrial Ca(2+) and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Reduced loading of intracellular Ca(2+) stores and downregulation of capacitative Ca(2+) influx in Bcl-2-overexpressing cells.

21 January 2018

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Maintenance of calcium homeostasis in the endoplasmic reticulum by Bcl-2

21 January 2018

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Bcl-2 on the endoplasmic reticulum: protecting the mitochondria from a distance

21 January 2018

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Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate.

21 January 2018

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Bcl-2 binds to and inhibits ryanodine receptors.

21 January 2018

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Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast

21 January 2018

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Voltage-dependent anion channel 1-based peptides interact with Bcl-2 to prevent antiapoptotic activity

21 January 2018

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

21 January 2018

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BH4 domain of antiapoptotic Bcl-2 family members closes voltage-dependent anion channel and inhibits apoptotic mitochondrial changes and cell death

21 January 2018

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Modulation of endoplasmic reticulum calcium pump by Bcl-2.

21 January 2018

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A novel role for Bcl-2 in regulation of cellular calcium extrusion

21 January 2018

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Endoplasmic reticulum calcium pumps and cancer

21 January 2018

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Plasma membrane calcium ATPases and cancer.

21 January 2018

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Bax inhibitor-1: a highly conserved endoplasmic reticulum-resident cell death suppressor.

21 January 2018

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Intracellular Ca2+ storage in health and disease: a dynamic equilibrium.

21 January 2018

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Non-apoptotic roles of Bcl-2 family: the calcium connection

21 January 2018

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Bcl-2 differentially regulates Ca2+ signals according to the strength of T cell receptor activation

21 January 2018

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Bcl-2 and Ca2+ homeostasis in the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

Endoplasmic-reticulum calcium depletion and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

When ER stress reaches a dead end

21 January 2018

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Regulation of inositol 1,4,5-trisphosphate receptors during endoplasmic reticulum stress

21 January 2018

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Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum

21 January 2018

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Feedback regulation mediated by Bcl-2 and DARPP-32 regulates inositol 1,4,5-trisphosphate receptor phosphorylation and promotes cell survival

21 January 2018

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Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: potential new target for cancer treatment

21 January 2018

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Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis.

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

BI-1 regulates an apoptosis pathway linked to endoplasmic reticulum stress

21 January 2018

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The ancient cell death suppressor BAX inhibitor-1.

21 January 2018

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BI-1 regulates endoplasmic reticulum Ca2+ homeostasis downstream of Bcl-2 family proteins

21 January 2018

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Bax Inhibitor-1 Is a pH-dependent regulator of Ca2+ channel activity in the endoplasmic reticulum

21 January 2018

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The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.

21 January 2018

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Bax inhibitor-1 is a novel IP₃ receptor-interacting and -sensitizing protein

21 January 2018

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Cardiolipin, phosphatidylserine, and BH4 domain of Bcl-2 family regulate Ca2+/H+ antiporter activity of human Bax inhibitor-1.

21 January 2018

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Human Golgi antiapoptotic protein modulates intracellular calcium fluxes

21 January 2018

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TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

21 January 2018

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TMBIM protein family: ancestral regulators of cell death

21 January 2018

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https://api.crossref.org/works/10.1038%2FONC.2016.31

hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2

21 January 2018

1 reference

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Human and viral Golgi anti-apoptotic proteins (GAAPs) oligomerize via different mechanisms and monomeric GAAP inhibits apoptosis and modulates calcium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The transmembrane Bax inhibitor motif (TMBIM) containing protein family: Tissue expression, intracellular localization and effects on the ER CA²⁺-filling state.

21 January 2018

1 reference

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Displacement of SERCA from SR lipid caveolae-related domains by Bcl-2: a possible mechanism for SERCA inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Anti-apoptotic protein Bcl-2 interacts with and destabilizes the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA).

21 January 2018

1 reference

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Evidence for a role of the sarcoplasmic/endoplasmic reticulum Ca(2+)-ATPase in thapsigargin and Bcl-2 induced changes in Xenopus laevis oocyte maturation

21 January 2018

1 reference

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Heat-shock proteins attenuate SERCA inactivation by the anti-apoptotic protein Bcl-2: possible implications for the ER Ca2+-mediated apoptosis

21 January 2018

1 reference

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Bcl-2 suppresses sarcoplasmic/endoplasmic reticulum Ca2+-ATPase expression in cystic fibrosis airways: role in oxidant-mediated cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2 suppresses Ca2+ release through inositol 1,4,5-trisphosphate receptors and inhibits Ca2+ uptake by mitochondria without affecting ER calcium store content

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Targeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Selective regulation of IP3-receptor-mediated Ca2+ signaling and apoptosis by the BH4 domain of Bcl-2 versus Bcl-Xl.

21 January 2018

1 reference

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The selective BH4-domain biology of Bcl-2-family members: IP3Rs and beyond

21 January 2018

1 reference

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Apoptosis protection by Mcl-1 and Bcl-2 modulation of inositol 1,4,5-trisphosphate receptor-dependent Ca2+ signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Alpha-helical destabilization of the Bcl-2-BH4-domain peptide abolishes its ability to inhibit the IP3 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

IP3R2 levels dictate the apoptotic sensitivity of diffuse large B-cell lymphoma cells to an IP3R-derived peptide targeting the BH4 domain of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The type 2 inositol 1,4,5-trisphosphate receptor, emerging functions for an intriguing Ca²⁺-release channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Endoplasmic reticulum calcium release through ITPR2 channels leads to mitochondrial calcium accumulation and senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3R

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Structural studies of inositol 1,4,5-trisphosphate receptor: coupling ligand binding to channel gating

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Inositol trisphosphate receptor Ca2+ release channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2-mediated alterations in endoplasmic reticulum Ca2+ analyzed with an improved genetically encoded fluorescent sensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gating.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Phosphorylated K-Ras limits cell survival by blocking Bcl-xL sensitization of inositol trisphosphate receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Autosis: a new addition to the cell death Tower of Babel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-X(L) affects Ca(2+) homeostasis by altering expression of inositol 1,4,5-trisphosphate receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

T cells deficient in inositol 1,4,5-trisphosphate receptor are resistant to apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Caspase-3-truncated type 1 inositol 1,4,5-trisphosphate receptor enhances intracellular Ca2+ leak and disturbs Ca2+ signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The regulatory domain of the inositol 1,4,5-trisphosphate receptor is necessary to keep the channel domain closed: possible physiological significance of specific cleavage by caspase 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Inositol 1,4,5-trisphosphate receptor type 1 is a substrate for caspase-3 and is cleaved during apoptosis in a caspase-3-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Degradation of the type I inositol 1,4,5-trisphosphate receptor by caspase-3 in SH-SY5Y neuroblastoma cells undergoing apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Caspase 3 cleavage of the inositol 1,4,5-trisphosphate receptor does not contribute to apoptotic calcium release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Type 1 inositol-1,4,5-trisphosphate receptor is a late substrate of caspases during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Ryanodine receptors are targeted by anti-apoptotic Bcl-XL involving its BH4 domain and Lys87 from its BH3 domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Mcl-1 involvement in mitochondrial dynamics is associated with apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The cellular concentration of Bcl-2 determines its pro- or anti-apoptotic effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-X(L) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

A novel cellular stress response characterised by a rapid reorganisation of membranes of the endoplasmic reticulum.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2 proteins regulate ER membrane permeability to luminal proteins during ER stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

VDAC, a multi-functional mitochondrial protein regulating cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1: mapping the site of binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

In self-defence: hexokinase promotes voltage-dependent anion channel closure and prevents mitochondria-mediated apoptotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Uncovering the role of VDAC in the regulation of cell life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The voltage-dependent anion channel-1 modulates apoptotic cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Mediation of the antiapoptotic activity of Bcl-xL protein upon interaction with VDAC1 protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The VDAC1 N-terminus is essential both for apoptosis and the protective effect of anti-apoptotic proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The BH4 domain of anti-apoptotic Bcl-XL, but not that of the related Bcl-2, limits the voltage-dependent anion channel 1 (VDAC1)-mediated transfer of pro-apoptotic Ca2+ signals to mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

NMR structural investigation of the mitochondrial outer membrane protein VDAC and its interaction with antiapoptotic Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

An interaction between Bcl-xL and the voltage-dependent anion channel (VDAC) promotes mitochondrial Ca2+ uptake

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Functions of BCL-X L at the Interface between Cell Death and Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Mcl-1 promotes lung cancer cell migration by directly interacting with VDAC to increase mitochondrial Ca2+ uptake and reactive oxygen species generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Regulation of sodium-calcium exchange and mitochondrial energetics by Bcl-2 in the heart of transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Mitochondrial fusion proteins: dual regulators of morphology and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Mito-Morphosis: Mitochondrial Fusion, Fission, and Cristae Remodeling as Key Mediators of Cellular Function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-2 family interaction with the mitochondrial morphogenesis machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bak regulates mitochondrial morphology and pathology during apoptosis by interacting with mitofusins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Role of Bax and Bak in mitochondrial morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The plasma membrane calcium pump in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The plethora of PMCA isoforms: Alternative splicing and differential expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The ER/PM microdomain, PI(4,5)P₂ and the regulation of STIM1-Orai1 channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

ER stress disrupts Ca2+-signaling complexes and Ca2+ regulation in secretory and muscle cells from PERK-knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Agonist-activated Ca2+ influx occurs at stable plasma membrane and endoplasmic reticulum junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Ca2+ entry through plasma membrane IP3 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

BCL2/BCL-X(L) inhibition induces apoptosis, disrupts cellular calcium homeostasis, and prevents platelet activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

HA14-1, but not the BH3 mimetic ABT-737, causes Ca2+ dysregulation in platelets and human cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Induction of Ca²+-driven apoptosis in chronic lymphocytic leukemia cells by peptide-mediated disruption of Bcl-2-IP3 receptor interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

HA14-1 potentiates apoptosis in B-cell cancer cells sensitive to a peptide disrupting IP 3 receptor / Bcl-2 complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Antagonizing Bcl-2's BH4 domain in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl2's flexible loop domain regulates p53 binding and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Conversion of Bcl-2 from protector to killer by interaction with nuclear orphan receptor Nur77/TR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Molecular structure and function of P2X receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Microdomains with high Ca2+ close to IP3-sensitive channels that are sensed by neighboring mitochondria

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Multifaceted plasma membrane Ca(2+) pumps: From structure to intracellular Ca(2+) handling and cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

CRAC channels, calcium, and cancer in light of the driver and passenger concept

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Calcium-ATPases: Gene disorders and dysregulation in cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca(2+) signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Targeting Calcium Signaling Induces Epigenetic Reactivation of Tumor Suppressor Genes in Cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The IP3 receptor as a hub for Bcl-2 family proteins in cell death control and beyond

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Profiling of the Bcl-2/Bcl-X(L)-binding sites on type 1 IP(3) receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

The mitochondrial channel VDAC has a cation-selective open state

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Bcl-xL-inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2016.31

Altered Ca(2+) signaling in cancer cells: proto-oncogenes and tumor suppressors targeting IP3 receptors.

31 March 2020

1 reference

12 December 2020

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production

1 reference

12 December 2020

The versatility and complexity of calcium signalling

1 reference

12 December 2020

The organisation and functions of local Ca(2+) signals.

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1038/ONC.2016.31

1 reference

Dimensions Publication ID

6 September 2017

0 references

1 reference