Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging (Q38765118)

6 September 2017

Potential Therapeutic Applications of Adenosine A2A Receptor Ligands and Opportunities for A2A Receptor Imaging (English)

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6 September 2017

Aren van Waarde

1

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6 September 2017

Rudi A J O Dierckx

2

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6 September 2017

Xiaoyun Zhou

3

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6 September 2017

Shivashankar Khanapur

4

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6 September 2017

Hideo Tsukada

5

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6 September 2017

Kiichi Ishiwata

6

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6 September 2017

Gert Luurtsema

7

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6 September 2017

Erik F J de Vries

8

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6 September 2017

Philip H Elsinga

9

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6 September 2017

27 January 2017

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Medicinal Research Reviews

6 September 2017

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Functional and molecular characterization of receptor subtypes mediating coronary microvascular dilation to adenosine

6 September 2017

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Involvement of NADPH oxidase in A2A adenosine receptor-mediated increase in coronary flow in isolated mouse hearts

21 January 2018

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Cardiovascular adenosine receptors: expression, actions and interactions

21 January 2018

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Growth regulation of the vascular system: an emerging role for adenosine

21 January 2018

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Role of adenosine receptors in the regulation of angiogenic factors and neovascularization in hypoxia.

21 January 2018

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Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

21 January 2018

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Adenosine receptors and wound healing.

21 January 2018

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Adenosine receptors in wound healing, fibrosis and angiogenesis.

21 January 2018

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Adenosine receptor agonists for promotion of dermal wound healing

21 January 2018

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Adenosine and sleep-wake regulation

21 January 2018

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Astrocytic modulation of sleep homeostasis and cognitive consequences of sleep loss

21 January 2018

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Roles of adenosine and its receptors in sleep-wake regulation

21 January 2018

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Adenosine, energy metabolism and sleep homeostasis

21 January 2018

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Adenosine receptor antagonists for cognitive dysfunction: a review of animal studies

21 January 2018

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Adenosine receptor control of cognition in normal and disease

21 January 2018

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Adenosine receptors in brain: neuromodulation and role in epilepsy

21 January 2018

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Homeostatic control of brain function - new approaches to understand epileptogenesis.

21 January 2018

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Adenosine dysfunction in epilepsy

21 January 2018

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Stimulation of Glia Reveals Modulation of Mammalian Spinal Motor Networks by Adenosine.

21 January 2018

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Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

21 January 2018

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Adenosine enhances glial glutamate efflux via A2a adenosine receptors

21 January 2018

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Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes.

21 January 2018

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Antagonistic interaction between adenosine A2A receptors and Na+/K+-ATPase-α2 controlling glutamate uptake in astrocytes

21 January 2018

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Adenosine: setting the stage for plasticity

21 January 2018

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Adenosine A(2A) receptor modulation of hippocampal CA3-CA1 synapse plasticity during associative learning in behaving mice

21 January 2018

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Functional cooperation of metabotropic adenosine and glutamate receptors regulates postsynaptic plasticity in the cerebellum

21 January 2018

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A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists

21 January 2018

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Extracellular adenosine concentrations during in vitro ischaemia in rat hippocampal slices

21 January 2018

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Adenosine in the central nervous system: release mechanisms and extracellular concentrations

21 January 2018

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Adenosine receptor subtypes

21 January 2018

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International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors--an update

21 January 2018

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Applications of adenosine receptor ligands in medical imaging by positron emission tomography

21 January 2018

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Adenosine receptor ligands and PET imaging of the CNS.

21 January 2018

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Adenosine A(1) receptors in the central nervous system: their functions in health and disease, and possible elucidation by PET imaging

21 January 2018

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Adenosine A(2A) receptor antagonists as Positron Emission Tomography (PET) tracers

21 January 2018

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Adenosine receptor PET imaging in human brain

21 January 2018

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Tissue distribution of adenosine receptor mRNAs in the rat.

21 January 2018

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Expression of adenosine A2a receptors gene in the olfactory bulb and spinal cord of rat and mouse.

21 January 2018

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Characterization and expression of the human A2a adenosine receptor gene

21 January 2018

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Distribution of adenosine A2 receptor mRNA in the human brain

21 January 2018

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The selective adenosine A2A receptor antagonist SCH 58261 discriminates between two different binding sites for [3H]-CGS 21680 in the rat brain.

21 January 2018

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Binding of the prototypical adenosine A(2A) receptor agonist CGS 21680 to the cerebral cortex of adenosine A(1) and A(2A) receptor knockout mice.

21 January 2018

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[(3)H]ZM241385--an antagonist radioligand for adenosine A(2A) receptors in rat brain

21 January 2018

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Localization of adenosine A2A-receptors in rat brain with [3H]ZM-241385.

21 January 2018

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Changes in purine levels and adenosine receptors in kindled seizures in the rat.

21 January 2018

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Effect of free radicals on adenosine A(2A) and dopamine D2 receptors in the striatum of young adult and aged rats

21 January 2018

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Different synaptic and subsynaptic localization of adenosine A2A receptors in the hippocampus and striatum of the rat.

21 January 2018

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Autoradiographic comparison of in vitro binding characteristics of various tritiated adenosine A2A receptor ligands in rat, mouse and pig brain and first ex vivo results.

21 January 2018

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Increased density and synapto-protective effect of adenosine A2A receptors upon sub-chronic restraint stress.

21 January 2018

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Modification of adenosine A1 and A2A receptor density in the hippocampus of streptozotocin-induced diabetic rats

21 January 2018

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Long-term effect of convulsive behavior on the density of adenosine A1 and A 2A receptors in the rat cerebral cortex

21 January 2018

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Increased expression of adenosine A2A receptors in patients with spontaneous and head-up-tilt-induced syncope

21 January 2018

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Influence of haemodialysis and left ventricular failure on peripheral A(2A) adenosine receptor expression.

21 January 2018

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Adenosine A2A receptor hyperexpression in patients with severe SIRS after cardiopulmonary bypass

21 January 2018

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Adenosine A2A receptor antagonists in Parkinson's disease: progress in clinical trials from the newly approved istradefylline to drugs in early development and those already discontinued

21 January 2018

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In vivo labelling of the adenosine A2A receptor in mouse brain using the selective antagonist [3H]SCH 58261.

21 January 2018

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Modulation of adenosine A1 and A2A receptors in C6 glioma cells during hypoxia: involvement of endogenous adenosine.

21 January 2018

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DNA methylation regulates adenosine A(2A) receptor cell surface expression levels.

21 January 2018

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Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction

21 January 2018

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Pharmacological and biochemical characterization of adenosine receptors in the human malignant melanoma A375 cell line

21 January 2018

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Adenosine A2A and A2B receptor expression in neuroendocrine tumours: potential targets for therapy

21 January 2018

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Fall in oxygen tension of culture medium stimulates the adenosinergic signalling of a human T cell line.

21 January 2018

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Monoclonal antibody-assisted stimulation of adenosine A2A receptors induces simultaneous downregulation of CXCR4 and CCR5 on CD4+ T-cells.

21 January 2018

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High homocysteine levels prevent via H2 S the CoCl2 -induced alteration of lymphocyte viability

21 January 2018

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Evidence for Coordinated Induction and Repression of Ecto-5'-Nucleotidase (CD73) and the A2a Adenosine Receptor in a Human B Cell Line

21 January 2018

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Differences in the order of potency for agonists but not antagonists at human and rat adenosine A2A receptors

21 January 2018

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Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells.

21 January 2018

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A2A adenosine receptors are up-regulated in lymphocytes from amyotrophic lateral sclerosis patients.

21 January 2018

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Upregulation of A2A adenosine receptors in platelets from patients affected by bipolar disorders under treatment with typical antipsychotics

21 January 2018

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How systemic inflammation modulates adenosine metabolism and adenosine receptor expression in humans in vivo

21 January 2018

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Adenosine A2A receptor dysfunction correlates with age at onset anticipation in blood platelets of subjects with Huntington's disease

21 January 2018

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The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea.

21 January 2018

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Adenosine A2A receptor expression in peripheral blood mononuclear cells of patients with mild cognitive impairment

21 January 2018

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Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated

21 January 2018

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A2A adenosine receptor overexpression and functionality, as well as TNF-alpha levels, correlate with motor symptoms in Parkinson's disease

21 January 2018

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Increased striatal adenosine A2A receptor levels is an early event in Parkinson's disease-related pathology and it is potentially regulated by miR-34b.

21 January 2018

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Adenosine A2A receptors are up-regulated in Pick's disease frontal cortex.

21 January 2018

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A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation, inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

21 January 2018

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Normalization of A2A and A3 adenosine receptor up-regulation in rheumatoid arthritis patients by treatment with anti-tumor necrosis factor alpha but not methotrexate

21 January 2018

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Up-regulation of striatal adenosine A(2A) receptors in schizophrenia

21 January 2018

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Upregulation of adenosine A2A receptors induced by atypical antipsychotics and its correlation with sensory gating in schizophrenia patients

21 January 2018

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Gene expression profiling by mRNA sequencing reveals increased expression of immune/inflammation-related genes in the hippocampus of individuals with schizophrenia

21 January 2018

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The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABA(A) receptor alterations in the human basal ganglia in Huntington's disease

21 January 2018

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Increased 5-methylcytosine and decreased 5-hydroxymethylcytosine levels are associated with reduced striatal A2AR levels in Huntington's disease

21 January 2018

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Reduced striatal adenosine A2A receptor levels define a molecular subgroup in schizophrenia.

21 January 2018

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Influence of age on BDNF modulation of hippocampal synaptic transmission: interplay with adenosine A2A receptors.

21 January 2018

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Treadmill running frequency on anxiety and hippocampal adenosine receptors density in adult and middle-aged rats

21 January 2018

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Increase in the number, G protein coupling, and efficiency of facilitatory adenosine A2A receptors in the limbic cortex, but not striatum, of aged rats.

21 January 2018

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Behavioural characteristics and gene expression in the hyperactive wiggling (Wig) rat.

21 January 2018

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Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes.

21 January 2018

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Up-regulation of A(2A) adenosine receptors by proinflammatory cytokines in rat PC12 cells

21 January 2018

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Striatum adenosine A2 receptors are modified during seizure: effect of cyclopentyladenosine administration.

21 January 2018

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Maternal glutamate intake during gestation and lactation regulates adenosine A₁ and A(2A) receptors in rat brain from mothers and neonates.

21 January 2018

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Early and transient alteration of adenosine A2A receptor signaling in a mouse model of Huntington disease

21 January 2018

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Genetic inactivation of the adenosine A(2A) receptor exacerbates brain damage in mice with experimental autoimmune encephalomyelitis.

21 January 2018

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Activation of the adenosine A2A receptor attenuates experimental autoimmune encephalomyelitis and is associated with increased intracellular calcium levels.

21 January 2018

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Upregulation of striatal adenosine A2A receptor mRNA in 6-hydroxydopamine-lesioned rats intermittently treated with L-DOPA.

21 January 2018

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Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.

21 January 2018

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Effect of low frequency electromagnetic fields on A2A adenosine receptors in human neutrophils

21 January 2018

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Characterization of adenosine receptors in bovine chondrocytes and fibroblast-like synoviocytes exposed to low frequency low energy pulsed electromagnetic fields

21 January 2018

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Effect of pulsed electromagnetic field exposure on adenosine receptors in rat brain.

21 January 2018

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Up-regulation of striatal adenosine A(2A) receptors with iron deficiency in rats: effects on locomotion and cortico-striatal neurotransmission

21 January 2018

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21 January 2018

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Effect of Caffeine Chronically Consumed During Pregnancy on Adenosine A1 and A2A Receptors Signaling in Both Maternal and Fetal Heart from Wistar Rats

21 January 2018

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Chronic sleep restriction induces long-lasting changes in adenosine and noradrenaline receptor density in the rat brain

21 January 2018

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Effect of hyperoxic and hyperbaric conditions on the adenosinergic pathway and CD26 expression in rat.

21 January 2018

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Changes in adenosine receptors in the neonatal rat brain following hypoxic ischemia.

21 January 2018

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The measurement of adenosine and estrogen receptor expression in rat brains following ovariectomy using quantitative PCR analysis.

21 January 2018

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Adenosine A2A and dopamine D2 heteromeric receptor complexes and their function

21 January 2018

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Association of ADORA1 rs2228079 and ADORA2A rs5751876 Polymorphisms with Gilles de la Tourette Syndrome in the Polish Population.

21 January 2018

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Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder

21 January 2018

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Adenosine A(2A) receptor gene: evidence for association of risk variants with panic disorder and anxious personality

21 January 2018

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Adenosine A(2A) receptor gene (ADORA2A) variants may increase autistic symptoms and anxiety in autism spectrum disorder.

21 January 2018

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Sympathetic activity relates to adenosine A(2A) receptor gene variation in blood-injury phobia

21 January 2018

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Association studies of the cholecystokinin B receptor and A2a adenosine receptor genes in panic disorder

21 January 2018

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Association study of A2a adenosine receptor genetic polymorphism in panic disorder

21 January 2018

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Adenosine through the A2A adenosine receptor increases IL-1β in the brain contributing to anxiety

21 January 2018

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Adenosine A2A Receptors in the Amygdala Control Synaptic Plasticity and Contextual Fear Memory.

21 January 2018

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Regulation of fear responses by striatal and extrastriatal adenosine A2A receptors in forebrain.

21 January 2018

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Aggressiveness, hypoalgesia and high blood pressure in mice lacking the adenosine A2a receptor

21 January 2018

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Evaluation of [4-O-methyl-(11)C]KW-6002 as a potential PET ligand for mapping central adenosine A(2A) receptors in rats

21 January 2018

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Positron emission tomography analysis of [11C]KW-6002 binding to human and rat adenosine A2A receptors in the brain

21 January 2018

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Design, radiosynthesis, and biodistribution of a new potent and selective ligand for in vivo imaging of the adenosine A(2A) receptor system using positron emission tomography

21 January 2018

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Characterization in humans of 18F-MNI-444, a PET radiotracer for brain adenosine 2A receptors

21 January 2018

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Synthesis and preclinical evaluation of 2-(2-furanyl)-7-[2-[4-[4-(2-[11C]methoxyethoxy)phenyl]-1-piperazinyl]ethyl]7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine-5-amine ([11C]Preladenant) as a PET tracer for the imaging of cerebral adenosine A2

21 January 2018

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Potential of an adenosine A2A receptor antagonist [11C]TMSX for myocardial imaging by positron emission tomography: a first human study

21 January 2018

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Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography.

21 January 2018

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Test-retest variability of adenosine A2A binding in the human brain with (11)C-TMSX and PET.

21 January 2018

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Potential of [11C]TMSX for the evaluation of adenosine A2A receptors in the skeletal muscle by positron emission tomography

21 January 2018

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Adenosine A2A receptor imaging with [11C]KF18446 PET in the rat brain after quinolinic acid lesion: comparison with the dopamine receptor imaging

21 January 2018

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Greater adenosine A(2A) receptor densities in cardiac and skeletal muscle in endurance-trained men: a [11C]TMSX PET study

21 January 2018

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Myocardial blood flow and adenosine A2A receptor density in endurance athletes and untrained men.

21 January 2018

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Differential effects of age on human striatal adenosine A₁ and A(2A) receptors.

21 January 2018

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Striatal adenosine A(2A) receptor-mediated positron emission tomographic imaging in 6-hydroxydopamine-lesioned rats using [(18)F]-MRS5425.

21 January 2018

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Adenosine A(2A) receptors measured with [C]TMSX PET in the striata of Parkinson's disease patients

21 January 2018

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Adenosine 2A receptor availability in dyskinetic and nondyskinetic patients with Parkinson disease

21 January 2018

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Adenosine A2A receptors in secondary progressive multiple sclerosis: a [(11)C]TMSX brain PET study.

21 January 2018

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Automated reference region extraction and population-based input function for brain [(11)C]TMSX PET image analyses

21 January 2018

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Functional architecture of basal ganglia circuits: neural substrates of parallel processing

21 January 2018

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Neurotransmitters and neuromodulators in the basal ganglia

21 January 2018

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A2 adenosine receptors: their presence and neuromodulatory role in the central nervous system

21 January 2018

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An overview of adenosine A2A receptor antagonists in Parkinson's disease

21 January 2018

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History and perspectives of A2A adenosine receptor antagonists as potential therapeutic agents

21 January 2018

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Istradefylline: first global approval

21 January 2018

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A long-term study of istradefylline safety and efficacy in patients with Parkinson disease.

21 January 2018

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Efficacy of adenosine A2A receptor antagonist istradefylline as augmentation for Parkinson's disease: a meta-analysis of randomized controlled trials

21 January 2018

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Preladenant as an Adjunctive Therapy With Levodopa in Parkinson Disease: Two Randomized Clinical Trials and Lessons Learned

21 January 2018

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Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats

21 January 2018

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The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats.

21 January 2018

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Altered distribution and function of A2A adenosine receptors in the brain of WAG/Rij rats with genetic absence epilepsy, before and after appearance of the disease

21 January 2018

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Differential neuroprotection by A(1) receptor activation and A(2A) receptor inhibition following pilocarpine-induced status epilepticus.

21 January 2018

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Adenosine A2A receptor deficient mice are partially resistant to limbic seizures

21 January 2018

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The adenosine A2A receptor antagonist ZM241385 enhances neuronal survival after oxygen-glucose deprivation in rat CA1 hippocampal slices

21 January 2018

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Blockade of A(2A) adenosine receptors leads to c-fos inhibition in a rat model of brain ischemia

21 January 2018

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The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat.

21 January 2018

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The selective A2A receptor antagonist SCH 58261 protects from neurological deficit, brain damage and activation of p38 MAPK in rat focal cerebral ischemia.

21 January 2018

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Selective adenosine A2a receptor antagonism reduces JNK activation in oligodendrocytes after cerebral ischaemia.

21 January 2018

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Role of adenosine A2A receptor in cerebral ischemia reperfusion injury: Signaling to phosphorylated extracellular signal-regulated protein kinase (pERK1/2).

21 January 2018

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Adenosine A2A receptor contributes to ischemic brain damage in newborn piglet

21 January 2018

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Time-course of protection by the selective A2A receptor antagonist SCH58261 after transient focal cerebral ischemia.

21 January 2018

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The effect of unpredictable chronic mild stress on depressive-like behavior and on hippocampal A1 and striatal A2A adenosine receptors.

21 January 2018

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Adenosine A2A receptor antagonists are potential antidepressants: evidence based on pharmacology and A2A receptor knockout mice

21 January 2018

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Characterization of the Potent and Highly Selective A(2A) Receptor Antagonists Preladenant and SCH 412348 [7-[2-[4-2,4-Difluorophenyl]-1-piperazinyl]ethyl]-2-(2-furanyl)-7H-pyraz olo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] in Rodent Models of

21 January 2018

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Antidepressant-like activity of the adenosine A(2A) receptor antagonist, istradefylline (KW-6002), in the forced swim test and the tail suspension test in rodents.

21 January 2018

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Adenosine A2A receptors and depression

21 January 2018

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Involvement of adenosine A2A receptors in depression and anxiety

21 January 2018

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Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists.

21 January 2018

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The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade.

21 January 2018

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Nucleus accumbens neurotransmission and effort-related choice behavior in food motivation: effects of drugs acting on dopamine, adenosine, and muscarinic acetylcholine receptors.

21 January 2018

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Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress

21 January 2018

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Caffeine reverses age-related deficits in olfactory discrimination and social recognition memory in rats. Involvement of adenosine A1 and A2A receptors.

21 January 2018

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Protective effect of caffeine and a selective A2A receptor antagonist on impairment of memory and oxidative stress of aged rats.

21 January 2018

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Caffeine regulates frontocorticostriatal dopamine transporter density and improves attention and cognitive deficits in an animal model of attention deficit hyperactivity disorder.

21 January 2018

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Blockade of adenosine A2A receptors reverses short-term social memory impairments in spontaneously hypertensive rats.

21 January 2018

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Adenosine receptor antagonists improve short-term object-recognition ability of spontaneously hypertensive rats: a rodent model of attention-deficit hyperactivity disorder

21 January 2018

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Working memory deficits in transgenic rats overexpressing human adenosine A2A receptors in the brain.

21 January 2018

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Improved spatial recognition memory in mice lacking adenosine A2A receptors

21 January 2018

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Preferential enhancement of working memory in mice lacking adenosine A(2A) receptors

21 January 2018

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A2A adenosine receptor deletion is protective in a mouse model of Tauopathy

21 January 2018

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Adenosine A2A receptor gene disruption protects in an α-synuclein model of Parkinson's disease

21 January 2018

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Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.

21 January 2018

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Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801.

21 January 2018

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Adenosine A2A receptor blockade prevents synaptotoxicity and memory dysfunction caused by beta-amyloid peptides via p38 mitogen-activated protein kinase pathway

21 January 2018

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Early synaptic deficits in the APP/PS1 mouse model of Alzheimer's disease involve neuronal adenosine A2A receptors

21 January 2018

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Hyperactivation of D1 and A2A receptors contributes to cognitive dysfunction in Huntington's disease

21 January 2018

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Inactivation of adenosine A2A receptors reverses working memory deficits at early stages of Huntington's disease models

21 January 2018

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Adenosine A2A receptor deficiency alleviates blast-induced cognitive dysfunction

21 January 2018

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The role of adenosine in Alzheimer's disease

21 January 2018

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Chronic caffeine consumption prevents memory disturbance in different animal models of memory decline

21 January 2018

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High expression of ecto-nucleotidases CD39 and CD73 in human endometrial tumors

21 January 2018

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The roles of CD73 in cancer

21 January 2018

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Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma.

21 January 2018

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CD73: a potent suppressor of antitumor immune responses

21 January 2018

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High expression of CD73 as a poor prognostic biomarker in human colorectal cancer

21 January 2018

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Overexpression of CD73 in prostate cancer is associated with lymph node metastasis

21 January 2018

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CD73 is associated with poor prognosis in high-grade serous ovarian cancer

21 January 2018

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The expression and clinical significance of CD73 molecule in human rectal adenocarcinoma

21 January 2018

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CD73 Expression Is an Independent Prognostic Factor in Prostate Cancer

21 January 2018

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Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia

21 January 2018

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Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity.

21 January 2018

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A2A adenosine receptor protects tumors from antitumor T cells.

21 January 2018

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A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments

21 January 2018

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The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway.

21 January 2018

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Extracellular adenosine-mediated modulation of regulatory T cells

21 January 2018

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Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment

21 January 2018

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Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor

21 January 2018

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Adenosine Receptor 2A Blockade Increases the Efficacy of Anti-PD-1 through Enhanced Antitumor T-cell Responses

21 January 2018

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Adenosine receptors and cancer.

21 January 2018

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Targeting the hypoxia-adenosinergic signaling pathway to improve the adoptive immunotherapy of cancer

21 January 2018

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Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer

21 January 2018

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Hostile, hypoxia-A2-adenosinergic tumor biology as the next barrier to overcome for tumor immunologists

21 January 2018

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A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy

21 January 2018

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CD73-adenosine: a next-generation target in immuno-oncology

21 January 2018

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A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

21 January 2018

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Hypoxia-dependent anti-inflammatory pathways in protection of cancerous tissues

21 January 2018

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From "Hellstrom Paradox" to anti-adenosinergic cancer immunotherapy

21 January 2018

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Adenosine A2A receptor antagonists: blockade of adenosinergic effects and T regulatory cells

21 January 2018

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Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

21 January 2018

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Extracellular adenosine induces apoptosis in Caco-2 human colonic cancer cells by activating caspase-9/-3 via A(2a) adenosine receptors

21 January 2018

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Caffeine promotes anti-tumor immune response during tumor initiation: Involvement of the adenosine A2A receptor

21 January 2018

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CD73-deficient mice are resistant to carcinogenesis

21 January 2018

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Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors

21 January 2018

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Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor

21 January 2018

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Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment

21 January 2018

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Measuring receptor occupancy with PET.

21 January 2018

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Brain adenosine A2A receptor occupancy by a novel A1/A2A receptor antagonist, ASP5854, in rhesus monkeys: relationship to anticataleptic effect

21 January 2018

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An open-label, positron emission tomography study to assess adenosine A2A brain receptor occupancy of vipadenant (BIIB014) at steady-state levels in healthy male volunteers

21 January 2018

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Adenosine 2A receptor occupancy by tozadenant and preladenant in rhesus monkeys

21 January 2018

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Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation.

21 January 2018

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Adenosine A2A activation attenuates nontransplantation lung reperfusion injury

21 January 2018

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The role of adenosine A2A receptor signaling in bronchiolitis obliterans

21 January 2018

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Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation.

21 January 2018

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Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death

21 January 2018

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Protective effect of adenosine A2A receptor activation in small-for-size liver transplantation.

21 January 2018

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Adenosine A(2A) agonist administration improves islet transplant outcome: Evidence for the role of innate immunity in islet graft rejection

21 January 2018

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Adenosine A2A receptor activation limits graft-versus-host disease after allogenic hematopoietic stem cell transplantation

21 January 2018

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Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition

21 January 2018

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Adenosine A2A receptor activation prevents wear particle-induced osteolysis

21 January 2018

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Direct or indirect stimulation of adenosine A2A receptors enhances bone regeneration as well as bone morphogenetic protein-2.

21 January 2018

1 reference

Graft versus host disease: New insights into A2A receptor agonist therapy

21 January 2018

1 reference

The effect of A2A adenosine receptor agonist on composite tissue allotransplant survival: an in vivo preliminary study

21 January 2018

1 reference

Reducing joint destruction due to septic arthrosis using an adenosine2A receptor agonist

21 January 2018

1 reference

Inhibition of small HA fragment activity and stimulation of A2A adenosine receptor pathway limit apoptosis and reduce cartilage damage in experimental arthritis.

21 January 2018

1 reference

Selective activation of adenosine A2A receptors on immune cells by a CD73-dependent prodrug suppresses joint inflammation in experimental rheumatoid arthritis

21 January 2018

1 reference

Effects of CGS 21680, a selective adenosine A2A receptor agonist, on allergic airways inflammation in the rat.

21 January 2018

1 reference

Effect of adenosine A2A receptor activation in murine models of respiratory disorders

21 January 2018

1 reference

Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury

21 January 2018

1 reference

Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice

21 January 2018

1 reference

Treating lung inflammation with agonists of the adenosine A2A receptor: promises, problems and potential solutions

21 January 2018

1 reference

Medicinal chemistry of adenosine A2A receptor agonists

21 January 2018

1 reference

The discovery of a selective and potent A2a agonist with extended lung retention

21 January 2018

1 reference

N6-1,3-diphenylurea derivatives of 2-phenyl-9-benzyladenines and 8-azaadenines: synthesis and biological evaluation as allosteric modulators of A2A adenosine receptors

21 January 2018

1 reference

Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation

21 January 2018

1 reference

Development of Polar Adenosine A2A Receptor Agonists for Inflammatory Bowel Disease: Synergism with A2B Antagonists

21 January 2018

1 reference

Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease

21 January 2018

1 reference

Effects of adenosine A₂A receptor activation and alanyl-glutamine in Clostridium difficile toxin-induced ileitis in rabbits and cecitis in mice

21 January 2018

1 reference

Effect of novel A2A adenosine receptor agonist ATL 313 on Clostridium difficile toxin A-induced murine ileal enteritis

21 January 2018

1 reference

Adenosine A2A receptor activation reduces recurrence and mortality from Clostridium difficile infection in mice following vancomycin treatment

21 January 2018

1 reference

Selective A2A adenosine agonist ATL-146e attenuates acute lethal liver injury in mice

21 January 2018

1 reference

Attenuation of gastric mucosal inflammation induced by aspirin through activation of A2A adenosine receptor in rats

21 January 2018

1 reference

Attenuation of gastric mucosal inflammation induced by indomethacin through activation of the A2A adenosine receptor in rats

21 January 2018

1 reference

A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence

21 January 2018

1 reference

Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors

21 January 2018

1 reference

Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis.

21 January 2018

1 reference

Adenosine A2A receptors promote adenosine-stimulated wound healing in bronchial epithelial cells

21 January 2018

1 reference

Adenosine receptors and wound healing, revised.

21 January 2018

1 reference

Pharmacological blockade of adenosine A2A receptors diminishes scarring

21 January 2018

1 reference

Adenosine A2A receptor plays an important role in radiation-induced dermal injury

21 January 2018

1 reference

Systemic administration of the adenosine A(2A) agonist CGS 21680 induces sedation at doses that suppress lever pressing and food intake

21 January 2018

1 reference

Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism

21 January 2018

1 reference

The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake

21 January 2018

1 reference

A2A adenosine receptor agonists reduce both high-palatability and low-palatability food intake in female rats.

21 January 2018

1 reference

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

21 January 2018

1 reference

Functional role of adenosine receptor subtypes in the regulation of blood-brain barrier permeability: possible implications for the design of synthetic adenosine derivatives

21 January 2018

1 reference

CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis

21 January 2018

1 reference

Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine

21 January 2018

1 reference

Human brain endothelial cells are responsive to adenosine receptor activation

21 January 2018

1 reference

Adenosine receptor signaling modulates permeability of the blood-brain barrier.

21 January 2018

1 reference

A2A Adenosine Receptor Regulates the Human Blood-Brain Barrier Permeability

21 January 2018

1 reference

Adenosine receptor signaling: a key to opening the blood-brain door

21 January 2018

1 reference

Overcoming the blood-brain barrier for delivering drugs into the brain by using adenosine receptor nanoagonist

21 January 2018

1 reference

Activation of adenosine receptor potentiates the anticonvulsant effect of phenytoin against amygdala kindled seizures.

21 January 2018

1 reference

The effect of regadenoson-induced transient disruption of the blood-brain barrier on temozolomide delivery to normal rat brain

21 January 2018

1 reference

A2A adenosine receptor modulates drug efflux transporter P-glycoprotein at the blood-brain barrier

21 January 2018

1 reference

Detection of subclinical synovitis with macrophage targeting and positron emission tomography in patients with rheumatoid arthritis without clinical arthritis.

21 January 2018

1 reference

Pharmacokinetic modelling of N-(4-[(18)F]fluorobenzoyl)interleukin-2 binding to activated lymphocytes in an xenograft model of inflammation

21 January 2018

1 reference

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

21 January 2018

1 reference

Brain regional pharmacokinetics of 11C-labeled diphenylhydantoin: positron emission tomography in humans.

21 January 2018

1 reference

Evaluation of brain and whole-body pharmacokinetics of 11C-labeled diphenylhydantoin in rats by means of planar positron imaging system

21 January 2018

1 reference

[11C]phenytoin revisited: synthesis by [11C]CO carbonylation and first evaluation as a P-gp tracer in rats

21 January 2018

1 reference

Quantification of Dynamic 11C-Phenytoin PET Studies.

21 January 2018

1 reference

Antitumor imidazotetrazines. 40. Radiosyntheses of [4-11C-carbonyl]- and [3-N-11C-methyl]-8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (temozolomide) for positron emission tomography (PET) studies

21 January 2018

1 reference

Synthesis of [3-N-(11) C-methyl]temozolomide via in situ activation of 3-N-hydroxymethyl temozolomide and alkylation with [(11) C]methyl iodide.

21 January 2018

1 reference

Comparative pharmacological studies on the A2 adenosine receptor agonist 5'-n-ethyl-carboxamidoadenosine and its F19 isotope labelled derivative

21 January 2018

1 reference

A biomathematical modeling approach to central nervous system radioligand discovery and development

21 January 2018

1 reference

Systematic mutation screening and association study of the A1 and A2a adenosine receptor genes in panic disorder suggest a contribution of the A2a gene to the development of disease

21 January 2018

1 reference

Extracellular Adenosine, Inosine, Hypoxanthine, and Xanthine in Relation to Tissue Nucleotides and Purines in Rat Striatum During Transient Ischemia

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1002/MED.21432

1 reference

6 September 2017

1 reference