Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance (Q38760082)

8 July 2018

review article

1 reference

title

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance (English)

1 reference

8 July 2018

1 reference

1 reference

2

Gerald I Shulman

1 reference

8 July 2018

Max C Petersen

1

1 reference

8 July 2018

publication date

24 May 2017

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8 July 2018

Trends in Pharmacological Sciences

published in

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8 July 2018

volume

38

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8 July 2018

issue

7

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8 July 2018

page(s)

649-665

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8 July 2018

Insulin's direct hepatic effect explains the inhibition of glucose production caused by insulin secretion

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Targeted Induction of Ceramide Degradation Leads to Improved Systemic Metabolism and Reduced Hepatic Steatosis

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Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice

10 July 2018

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Estrogen signaling prevents diet-induced hepatic insulin resistance in male mice with obesity

10 July 2018

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Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice

10 July 2018

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10 July 2018

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Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

10 July 2018

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Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

10 July 2018

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Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

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Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

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CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

10 July 2018

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10 July 2018

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10 July 2018

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Studies on the substrate and stereo/regioselectivity of adipose triglyceride lipase, hormone-sensitive lipase, and diacylglycerol-O-acyltransferases

10 July 2018

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Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

10 July 2018

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Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

10 July 2018

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A ceramide-centric view of insulin resistance

10 July 2018

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Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

10 July 2018

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10 July 2018

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Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis

10 July 2018

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Intrahepatic diacylglycerol content is associated with hepatic insulin resistance in obese subjects

10 July 2018

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Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

10 July 2018

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10 July 2018

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Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

10 July 2018

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Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

10 July 2018

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Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

10 July 2018

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Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

10 July 2018

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Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

10 July 2018

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Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

10 July 2018

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Endoplasmic reticulum stress promotes LIPIN2-dependent hepatic insulin resistance

10 July 2018

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The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

10 July 2018

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Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

10 July 2018

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10 July 2018

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A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

10 July 2018

1 reference

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CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

10 July 2018

1 reference

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Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

10 July 2018

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10 July 2018

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10 July 2018

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Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity

10 July 2018

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Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

10 July 2018

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10 July 2018

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10 July 2018

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Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects

10 July 2018

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Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

10 July 2018

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Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

10 July 2018

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Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance.

10 July 2018

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Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

10 July 2018

1 reference

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Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance

10 July 2018

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Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

10 July 2018

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Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

10 July 2018

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10 July 2018

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Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

10 July 2018

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Insulin resistance: a metabolic pathway to chronic liver disease

10 July 2018

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Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

10 July 2018

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Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes

10 July 2018

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Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

10 July 2018

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Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

10 July 2018

1 reference

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Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

10 July 2018

1 reference

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Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

10 July 2018

1 reference

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Prevention of fat-induced insulin resistance by salicylate

10 July 2018

1 reference

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Mechanism by which metformin reduces glucose production in type 2 diabetes

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Distinct effects of fatty acids on translocation of gamma- and epsilon-subspecies of protein kinase C

10 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

10 July 2018

12 December 2020

Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis

1 reference

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Diacylglycerol/protein kinase C signalling: a mechanism for insulin resistance?

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells

10 July 2018

1 reference

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Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity

10 July 2018

1 reference

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Alteration of insulin-receptor kinase activity by high-fat feeding.

10 July 2018

1 reference

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Liver pathology in morbidly obese patients with and without diabetes

10 July 2018

1 reference

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1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

10 July 2018

1 reference

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Peripheral effects of insulin dominate suppression of fasting hepatic glucose production

10 July 2018

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Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice.

10 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Duodenal-jejunal bypass surgery induces hepatic lipidomic alterations associated with ameliorated hepatic steatosis in mice

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

CrossTalk opposing view: Intramyocellular ceramide accumulation does not modulate insulin resistance.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

CrossTalk proposal: Intramyocellular ceramide accumulation does modulate insulin resistance.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Independent Association Between Improvement of Nonalcoholic Fatty Liver Disease and Reduced Incidence of Type 2 Diabetes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Analysis of the liver lipidome reveals insights into the protective effect of exercise on high-fat diet-induced hepatosteatosis in mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Inhibition of ceramide de novo synthesis reduces liver lipid accumulation in rats with nonalcoholic fatty liver disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Time-dependent effects of Prkce deletion on glucose homeostasis and hepatic lipid metabolism on dietary lipid oversupply in mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Adipose triglyceride lipase-null mice are resistant to high-fat diet-induced insulin resistance despite reduced energy expenditure and ectopic lipid accumulation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

TORC2 regulates hepatic insulin signaling via a mammalian phosphatidic acid phosphatase, LIPIN1.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Obesity and type 2 diabetes impair insulin-induced suppression of glycogenolysis as well as gluconeogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Liver-fat accumulation and insulin resistance in obese women with previous gestational diabetes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Gluconeogenesis in moderately and severely hyperglycemic patients with type 2 diabetes mellitus

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Inhibition of PKB/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Association of nonalcoholic fatty liver disease with insulin resistance.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5499157

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

3 December 2018

1 reference

12 December 2020

Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding

1 reference

12 December 2020

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

1 reference

12 December 2020

Activation of conventional and novel protein kinase C isozymes by different diacylglycerol molecular species.

1 reference

12 December 2020

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity

1 reference

12 December 2020

The stereospecific activation of protein kinase C

1 reference

12 December 2020

The direct and indirect effects of insulin on hepatic glucose production in vivo

1 reference

12 December 2020

10.1016/J.TIPS.2017.04.004

Identifiers

DOI

1 reference

8 July 2018

PMC publication ID

5499157

1 reference

8 July 2018

PubMed publication ID

28551355

1 reference

8 July 2018