Translating the Science of Aging into Therapeutic Interventions (Q38756902)

18 May 2018

title

Translating the Science of Aging into Therapeutic Interventions (English)

1 reference

18 May 2018

author name string

James L Kirkland

series ordinal

1

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18 May 2018

publication date

1 March 2016

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18 May 2018

Cold Spring Harbor Perspectives in Medicine

published in

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18 May 2018

volume

6

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18 May 2018

issue

3

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18 May 2018

page(s)

a025908

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18 May 2018

Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs

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Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors

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The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

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Drugs that modulate aging: the promising yet difficult path ahead

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

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Substantial health and economic returns from delayed aging may warrant a new focus for medical research

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Metformin improves healthspan and lifespan in mice

23 June 2018

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Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial

23 June 2018

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Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling

23 June 2018

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Clinical ascertainment of health outcomes among adults treated for childhood cancer

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Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

23 June 2018

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Rapalogs and mTOR inhibitors as anti-aging therapeutics

23 June 2018

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Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

23 June 2018

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The key role of growth hormone-insulin-IGF-1 signaling in aging and cancer

23 June 2018

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DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism

23 June 2018

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Translating advances from the basic biology of aging into clinical application

23 June 2018

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Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease

23 June 2018

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Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon.

23 June 2018

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Comparative effectiveness of sulfonylurea and metformin monotherapy on cardiovascular events in type 2 diabetes mellitus: a cohort study

23 June 2018

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Are sirtuins viable targets for improving healthspan and lifespan?

23 June 2018

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

23 June 2018

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Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy

23 June 2018

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The caloric restriction paradigm: implications for healthy human aging

23 June 2018

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Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model

23 June 2018

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Lifelong rapamycin administration ameliorates age-dependent cognitive deficits by reducing IL-1β and enhancing NMDA signaling

23 June 2018

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Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

23 June 2018

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Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells

23 June 2018

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Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies

23 June 2018

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Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

23 June 2018

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Weight loss, exercise, or both and physical function in obese older adults

23 June 2018

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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

23 June 2018

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Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

23 June 2018

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Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials

23 June 2018

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Single-gene mutations and healthy ageing in mammals

23 June 2018

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Metformin and cancer occurrence in insulin-treated type 2 diabetic patients

23 June 2018

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Fat tissue, aging, and cellular senescence

23 June 2018

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Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

23 June 2018

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Exceptional parental longevity associated with lower risk of Alzheimer's disease and memory decline

23 June 2018

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Metformin supplementation and life span in Fischer-344 rats

23 June 2018

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Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease

23 June 2018

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Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis

23 June 2018

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Measuring systemic inflammatory regulation in older adults: evidence and utility

23 June 2018

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Inflammation and cancer: interweaving microRNA, free radical, cytokine and p53 pathways

23 June 2018

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Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

23 June 2018

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

23 June 2018

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Endogenous damage-associated molecular pattern molecules at the crossroads of inflammation and cancer

23 June 2018

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Nonlinear multisystem physiological dysregulation associated with frailty in older women: implications for etiology and treatment

23 June 2018

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

23 June 2018

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Inflammation, coagulation, and the pathway to frailty

23 June 2018

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The basics of preclinical drug development for neurodegenerative disease indications

23 June 2018

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Inflammation and stress-related candidate genes, plasma interleukin-6 levels, and longevity in older adults

23 June 2018

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Can we develop genetically tractable models to assess healthspan (rather than life span) in animal models?

23 June 2018

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Healthspan, translation, and new outcomes for animal studies of aging

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis

23 June 2018

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Upregulated ex vivo expression of stress-responsive inflammatory pathway genes by LPS-challenged CD14(+) monocytes in frail older adults.

23 June 2018

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

23 June 2018

1 reference

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Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

23 June 2018

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Murine models of pulmonary fibrosis.

23 June 2018

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The influence of age on the effects of lifestyle modification and metformin in prevention of diabetes

23 June 2018

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Research agenda for frailty in older adults: toward a better understanding of physiology and etiology: summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults

23 June 2018

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Phenotype of frailty: characterization in the women's health and aging studies

23 June 2018

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Development of 17alpha-estradiol as a neuroprotective therapeutic agent: rationale and results from a phase I clinical study

23 June 2018

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Protective effect of the inhibition of the renin-angiotensin system on aging

23 June 2018

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Leukocyte count as a predictor of cardiovascular events and mortality in postmenopausal women: the Women's Health Initiative Observational Study

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Inflammatory markers and the risk of coronary heart disease in men and women

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Frailty in older adults: evidence for a phenotype

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

White blood cell count: an independent predictor of coronary heart disease mortality among a national cohort

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Whose quality of life is it anyway? Why not ask seniors to tell us about it?

23 June 2018

1 reference

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Serum IL-6 level and the development of disability in older persons

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Long-term ACE inhibition doubles lifespan of hypertensive rats

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.

31 August 2018

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Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias

31 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Angiotensin II receptor blockers and risk of cancer in patients with systemic hypertension.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Frailty defined by deficit accumulation and geriatric medicine defined by frailty.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

31 August 2018

1 reference

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An index of self-rated health deficits in relation to frailty and adverse outcomes in older adults.

31 August 2018

1 reference

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Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Long term treatment with ACE inhibitor enalapril decreases body weight gain and increases life span in rats.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Metformin slows down aging and extends life span of female SHR mice.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label study.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Inflammation and frailty in older women.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Sources of life strengths as predictors of late-life mortality and survivorship.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with Type 2 diabetes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Effect of acarbose treatment on the risk of silent myocardial infarctions in patients with impaired glucose tolerance: results of the randomised STOP-NIDDM trial electrocardiography substudy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Inflammatory markers and risk of developing type 2 diabetes in women.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Elevated levels of tumor necrosis factor alpha and mortality in centenarians.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study).

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Use of Angiotensin Receptor Blockers and the Risk of Cancer

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Long-Term Risks of Death and Institutionalization of Elderly People in Relation to Deficit Accumulation at Age 70

3 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4772076

Long-term angiotensin II type 1 receptor blockade with fonsartan doubles lifespan of hypertensive rats

3 December 2018

1 reference

12 December 2020

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

1 reference

12 December 2020

In search of Methuselah: estimating the upper limits to human longevity

1 reference

12 December 2020

Effects of angiotensin-converting enzyme inhibition on mitochondrial number in the aging mouse

1 reference

12 December 2020

Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly

1 reference

12 December 2020

Protective effect of long-term angiotensin II inhibition

1 reference

12 December 2020

Effect of metformin on IGF-1 and IGFBP-1 levels in obese patients with polycystic ovary syndrome

1 reference

12 December 2020

C-reactive protein, interleukin-6 and tumor necrosis factor alpha as predictors of incident coronary and cardiovascular events and total mortality. A population-based, prospective study

1 reference

12 December 2020

10.1101/CSHPERSPECT.A025908

Identifiers

DOI

1 reference

18 May 2018

PMCID

4772076

1 reference

18 May 2018

PubMed ID

26931808

1 reference

18 May 2018