Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain. (Q38756584)

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19 March 2020

title

Identification of a novel BCL2-specific inhibitor that binds predominantly to the BH1 domain (English)

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19 March 2020

13

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19 March 2020

8

Vidya Gopalakrishnan

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Sathees Chukkurumbal Raghavan

19 March 2020

15

object named as

Sathees C Raghavan

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19 March 2020

author name string

Divyaanka Iyer

1

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19 March 2020

Supriya V Vartak

2

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19 March 2020

Archita Mishra

3

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19 March 2020

Gunaseelan Goldsmith

4

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19 March 2020

Sujeet Kumar

5

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19 March 2020

Mrinal Srivastava

6

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19 March 2020

Mahesh Hegde

7

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19 March 2020

Mark Glenn

9

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19 March 2020

Mahesh Velusamy

10

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19 March 2020

Bibha Choudhary

11

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19 March 2020

Nagesh Kalakonda

12

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19 March 2020

Avadhesha Surolia

14

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19 March 2020

language of work or name

English

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publication date

17 August 2016

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19 March 2020

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19 March 2020

volume

283

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19 March 2020

issue

18

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19 March 2020

page(s)

3408-3437

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Apoptosis and cancer: the genesis of a research field

19 March 2020

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

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BCL-2 family members and the mitochondria in apoptosis

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Up-regulation of Bcl-2 is required for the progression of prostate cancer cells from an androgen-dependent to an androgen-independent growth stage

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The role of Bcl-2 family members in tumorigenesis

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Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells

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Protein-protein interactions and cancer: small molecules going in for the kill

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Breast cancer cells can evade apoptosis-mediated selective killing by a novel small molecule inhibitor of Bcl-2

21 January 2018

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

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ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

21 January 2018

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TW-37, a small-molecule inhibitor of Bcl-2, inhibits cell growth and induces apoptosis in pancreatic cancer: involvement of Notch-1 signaling pathway

21 January 2018

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Synthesis and kinase inhibitory activity of novel substituted indigoids.

21 January 2018

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Synthesis, structure-activity relationship and crystallographic studies of 3-substituted indolin-2-one RET inhibitors

21 January 2018

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Antitumor activities of a novel indolin-2-ketone compound, Z24: more potent inhibition on bFGF-induced angiogenesis and bcl-2 over-expressing cancer cells

21 January 2018

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Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells

21 January 2018

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Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination

21 January 2018

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The use of differential scanning fluorimetry to detect ligand interactions that promote protein stability

21 January 2018

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A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases

21 January 2018

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A novel DNA intercalator, 8-methoxy pyrimido[4',5':4,5]thieno (2,3-b)quinoline-4(3H)-one induces apoptosis in cancer cells, inhibits the tumor progression and enhances lifespan in mice with tumor

21 January 2018

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A short Nur77-derived peptide converts Bcl-2 from a protector to a killer

21 January 2018

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Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).

21 January 2018

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Sensitization of BCL-2-expressing breast tumors to chemotherapy by the BH3 mimetic ABT-737

21 January 2018

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Multiparametric analysis of HA14-1-induced apoptosis in follicular lymphoma cells

21 January 2018

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Targeting BCL-2 with the BH3 mimetic ABT-199 in estrogen receptor-positive breast cancer

21 January 2018

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BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines

21 January 2018

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Selective BCL-2 inhibition by ABT-199 causes on-target cell death in acute myeloid leukemia

21 January 2018

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Both leukaemic and normal peripheral B lymphoid cells are highly sensitive to the selective pharmacological inhibition of prosurvival Bcl-2 with ABT-199.

21 January 2018

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Synthesis and biological evaluation of novel 2-aralkyl-5-substituted-6-(4'-fluorophenyl)-imidazo[2,1-b][1,3,4]thiadiazole derivatives as potent anticancer agents.

21 January 2018

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21 January 2018

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A novel DNA intercalator, butylamino-pyrimido[4',5':4,5]selenolo(2,3-b)quinoline, induces cell cycle arrest and apoptosis in leukemic cells

21 January 2018

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ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Propyl-2-(8-(3,4-difluorobenzyl)-2',5'-dioxo-8-azaspiro[bicyclo[3.2.1] octane-3,4'-imidazolidine]-1'-yl) acetate induces apoptosis in human leukemia cells through mitochondrial pathway following cell cycle arrest

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21 January 2018

Identifiers

DOI

10.1111/FEBS.13815

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27444341%20AND%20SRC:MED&resulttype=core&format=json

19 March 2020

1 reference