Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha. (Q38744439)

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scientific article published on September 2016

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English	Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha.	scientific article published on September 2016

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scholarly article

1 reference

Europe PubMed Central

6 September 2017

Involvement of Spinal IL-6 Trans-Signaling in the Induction of Hyperexcitability of Deep Dorsal Horn Neurons by Spinal Tumor Necrosis Factor-Alpha (English)

1 reference

Europe PubMed Central

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12 May 2020

Brian Turnquist

5

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12 May 2020

author name string

Christian König

1

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12 May 2020

Eric Morch

2

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12 May 2020

Annett Eitner

3

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12 May 2020

Christian Möller

4

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12 May 2020

Hans-Georg Schaible

6

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12 May 2020

Andrea Ebersberger

7

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12 May 2020

language of work or name

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publication date

1 September 2016

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6 September 2017

Journal of Neuroscience

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12 May 2020

36

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12 May 2020

38

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12 May 2020

9782-9791

1 reference

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12 May 2020

CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

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Neuronal plasticity: increasing the gain in pain

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https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

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https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Adjuvant-induced arthritis: IL-1 beta, IL-6 and TNF-alpha are up-regulated in the spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Interleukin-6 (IL-6): a possible neuromodulator induced by neuronal activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Microglia as a source and target of cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Soluble IL-6 Receptor Governs IL-6 Activity in Experimental Arthritis: Blockade of Arthritis Severity by Soluble Glycoprotein 130

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Complete Freunds adjuvant-induced peripheral inflammation evokes glial activation and proinflammatory cytokine expression in the CNS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Neural spike classification using parallel selection of all algorithm parameters.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Role of the immune system in chronic pain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Sensitization of unmyelinated sensory fibers of the joint nerve to mechanical stimuli by interleukin-6 in the rat: an inflammatory mechanism of joint pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of spinal microglial cathepsin S for the reversal of neuropathic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal glial activation contributes to pathological pain states

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential implication of proinflammatory cytokine interleukin-6 in the development of cephalic versus extracephalic neuropathic pain in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathological and protective roles of glia in chronic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Context-dependent IL-6 potentiation of interferon- gamma-induced IL-12 secretion and CD40 expression in murine microglia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current challenges in glia-pain biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor necrosis factor causes persistent sensitization of joint nociceptors to mechanical stimuli in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

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Characterization of the acute and persistent pain state present in K/BxN serum transfer arthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6- and NGF-induced rapid control of protein synthesis and nociceptive plasticity via convergent signaling to the eIF4F complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF-α contributes to spinal cord synaptic plasticity and inflammatory pain: distinct role of TNF receptor subtypes 1 and 2.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Species specificity of ADAM10 and ADAM17 proteins in interleukin-6 (IL-6) trans-signaling and novel role of ADAM10 in inducible IL-6 receptor shedding

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute inhibition of signalling phenotype of spinal GABAergic neurons by tumour necrosis factor-alpha.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The contribution of spinal glial cells to chronic pain behaviour in the monosodium iodoacetate model of osteoarthritic pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Modulation of spinal cord synaptic activity by tumor necrosis factor α in a model of peripheral neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spinal interleukin-6 is an amplifier of arthritic pain in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNFα in synaptic function: switching gears.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Central pain mechanisms in the rheumatic diseases: future directions

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 trans-signaling via the soluble IL-6 receptor: importance for the pro-inflammatory activities of IL-6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6, a major cytokine in the central nervous system

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Minocycline: far beyond an antibiotic

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of IL-6 signaling: A novel therapeutic approach to treating spinal cord injury pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glia and pain: is chronic pain a gliopathy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phagocytosis executes delayed neuronal death after focal brain ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Involvement of peripheral and spinal tumor necrosis factor α in spinal cord hyperexcitability during knee joint inflammation in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of IL-6/gp130 family receptor expression reveals that in contrast to astroglia, microglia lack the oncostatin M receptor and functional responses to oncostatin M

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different immune cells mediate mechanical pain hypersensitivity in male and female mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-6 pathway in the liver: From physiopathology to therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of interleukin-6 signaling in nervous tissue

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-6 mRNA expression by cortical neurons in culture: evidence for neuronal sources of interleukin-6 production in the brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of interleukin-6 mRNA in the spinal cord following peripheral nerve injury in the rat: potential role of IL-6 in neuropathic pain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/27656018

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1523/JNEUROSCI.4159-15.2016

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6705568&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6705568&resulttype=core&format=json

12 May 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6705568&resulttype=core&format=json

12 May 2020

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