Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial. (Q38737680)

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scientific article published on 02 June 2017

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English	Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial.	scientific article published on 02 June 2017

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scholarly article

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22 March 2020

Dabrafenib plus trametinib in patients with BRAFV600-mutant melanoma brain metastases (COMBI-MB): a multicentre, multicohort, open-label, phase 2 trial (English)

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22 March 2020

phase II clinical trial

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multicenter clinical trial

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22 March 2020

Georgina V. Long

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22 March 2020

Vanna Chiarion Sileni

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Laurent Mortier

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Ivan Marquez-Rodas

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author name string

Michael A Davies

1

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22 March 2020

Philippe Saiag

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22 March 2020

Thierry Lesimple

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22 March 2020

Stergios J Moschos

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22 March 2020

David Hogg

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22 March 2020

Michele Del Vecchio

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22 March 2020

Céleste Lebbé

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22 March 2020

Ying Zhang

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22 March 2020

Yingjie Huang

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22 March 2020

Bijoyesh Mookerjee

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22 March 2020

Caroline Robert

3

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22 March 2020

Jean-Jacques Grob

4

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22 March 2020

Keith T Flaherty

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publication date

4 June 2017

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22 March 2020

Lancet Oncology Commission

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22 March 2020

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7

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22 March 2020

863-873

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22 March 2020

Dabrafenib plus trametinib versus dabrafenib monotherapy in patients with metastatic BRAF V600E/K-mutant melanoma: long-term survival and safety analysis of a phase 3 study

1 reference

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10 July 2018

The mitogen-activated protein kinase pathway in melanoma part I - Activation and primary resistance mechanisms to BRAF inhibition.

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10 July 2018

Factors predictive of response, disease progression, and overall survival after dabrafenib and trametinib combination treatment: a pooled analysis of individual patient data from randomised trials

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10 July 2018

Melanoma central nervous system metastases: current approaches, challenges, and opportunities

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10 July 2018

Cobimetinib combined with vemurafenib in advanced BRAF(V600)-mutant melanoma (coBRIM): updated efficacy results from a randomised, double-blind, phase 3 trial

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10 July 2018

Pembrolizumab for patients with melanoma or non-small-cell lung cancer and untreated brain metastases: early analysis of a non-randomised, open-label, phase 2 trial

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10 July 2018

Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial

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10 July 2018

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

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10 July 2018

Pembrolizumab versus Ipilimumab in Advanced Melanoma

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10 July 2018

Improved overall survival in melanoma with combined dabrafenib and trametinib

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10 July 2018

Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma

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10 July 2018

Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the PI3K pathway as a therapeutic target

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10 July 2018

Vemurafenib in patients with BRAF(V600) mutation-positive melanoma with symptomatic brain metastases: final results of an open-label pilot study

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10 July 2018

Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases

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10 July 2018

Multidisciplinary approach to brain metastasis from melanoma: the emerging role of systemic therapies

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10 July 2018

Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations

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10 July 2018

Brain and leptomeningeal metastases from cutaneous melanoma: survival outcomes based on clinical features

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10 July 2018

Determinants of outcome in melanoma patients with cerebral metastases

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10 July 2018

Demographics, prognosis, and therapy in 702 patients with brain metastases from malignant melanoma.

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10 July 2018

Overall Survival and Durable Responses in Patients With BRAF V600-Mutant Metastatic Melanoma Receiving Dabrafenib Combined With Trametinib.

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31 August 2018

Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial

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31 August 2018

Ipilimumab in patients with melanoma and brain metastases: an open-label, phase 2 trial.

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Prognostic factors for survival in melanoma patients with brain metastases

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Identifiers

10.1016/S1470-2045(17)30429-1

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22 March 2020

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22 March 2020

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