A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens. (Q38719407)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28628042%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

A therapeutic T cell receptor mimic antibody targets tumor-associated PRAME peptide/HLA-I antigens (English)

1 reference

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23 March 2020

3

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23 March 2020

Casey Jarvis

4

1 reference

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23 March 2020

Andrew C Scott

5

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23 March 2020

Leonid Dubrovsky

6

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23 March 2020

author name string

Aaron Y Chang

1

1 reference

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23 March 2020

Tao Dao

2

1 reference

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23 March 2020

Melissa D Mathias

7

1 reference

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23 March 2020

Tatyana Korontsvit

8

1 reference

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23 March 2020

Victoriya Zakhaleva

9

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23 March 2020

Michael Curcio

10

1 reference

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23 March 2020

Ronald C Hendrickson

11

1 reference

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23 March 2020

Cheng Liu

12

1 reference

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23 March 2020

David A Scheinberg

13

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23 March 2020

language of work or name

English

0 references

publication date

19 June 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28628042%20AND%20SRC:MED&resulttype=core&format=json

Journal of Clinical Investigation

23 March 2020

published in

1 reference

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23 March 2020

volume

127

1 reference

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23 March 2020

issue

7

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23 March 2020

page(s)

2705-2718

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Optimized T-cell receptor-mimic chimeric antigen receptor T cells directed toward the intracellular Wilms Tumor 1 antigen.

23 March 2020

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Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

23 June 2018

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23 June 2018

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Therapeutic efficacy of an Fc-enhanced TCR-like antibody to the intracellular WT1 oncoprotein

23 June 2018

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A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias

23 June 2018

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5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies.

23 June 2018

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Anti-melanoma activity of T cells redirected with a TCR-like chimeric antigen receptor

23 June 2018

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Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells

23 June 2018

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The resistance mechanisms of proteasome inhibitor bortezomib

23 June 2018

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Generation of tumor antigen-specific T cell lines from pediatric patients with acute lymphoblastic leukemia--implications for immunotherapy

23 June 2018

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PRAME Gene Expression in Acute Leukemia and Its Clinical Significance

23 June 2018

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Targeting the intracellular WT1 oncogene product with a therapeutic human antibody.

23 June 2018

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PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs

23 June 2018

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PRAME-induced inhibition of retinoic acid receptor signaling-mediated differentiation--a possible target for ATRA response in AML without t(15;17).

23 June 2018

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Analysis of the processing of seven human tumor antigens by intermediate proteasomes.

23 June 2018

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Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

23 June 2018

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Immunoproteasomes: structure, function, and antigen presentation

23 June 2018

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Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity

23 June 2018

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Mice completely lacking immunoproteasomes show major changes in antigen presentation

23 June 2018

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A phase 1 study of a vaccine targeting preferentially expressed antigen in melanoma and prostate-specific membrane antigen in patients with advanced solid tumors

23 June 2018

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Increased PRAME antigen-specific killing of malignant cell lines by low avidity CTL clones, following treatment with 5-Aza-2'-Deoxycytidine

23 June 2018

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An anti-PR1/HLA-A2 T-cell receptor-like antibody mediates complement-dependent cytotoxicity against acute myeloid leukemia progenitor cells

23 June 2018

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TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms.

23 June 2018

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A MAGE-C2 antigenic peptide processed by the immunoproteasome is recognized by cytolytic T cells isolated from a melanoma patient after successful immunotherapy

23 June 2018

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Characterization of chronic myeloid leukemia stem cells.

23 June 2018

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Leucine-rich repeat protein PRAME: expression, potential functions and clinical implications for leukaemia

23 June 2018

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Therapeutic antibodies for autoimmunity and inflammation

23 June 2018

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Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases

23 June 2018

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Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.

23 June 2018

1 reference

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Cytotoxic T lymphocytes directed to the preferentially expressed antigen of melanoma (PRAME) target chronic myeloid leukemia

23 June 2018

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A causal role for the human tumor antigen preferentially expressed antigen of melanoma in cancer

23 June 2018

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Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura

23 June 2018

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Gene expression changes associated with progression and response in chronic myeloid leukemia

23 June 2018

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The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5490756

Tumor-associated antigen preferentially expressed antigen of melanoma (PRAME) induces caspase-independent cell death in vitro and reduces tumorigenicity in vivo

23 June 2018

1 reference

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The tumor-associated antigen PRAME is universally expressed in high-stage neuroblastoma and associated with poor outcome

23 June 2018

1 reference

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mRNA expression of leukemia-associated antigens in patients with acute myeloid leukemia for the development of specific immunotherapies

23 June 2018

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The absence of fucose but not the presence of galactose or bisecting N-acetylglucosamine of human IgG1 complex-type oligosaccharides shows the critical role of enhancing antibody-dependent cellular cytotoxicity

23 June 2018

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Tumor therapy with targeted atomic nanogenerators

23 June 2018

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Discrete cleavage motifs of constitutive and immunoproteasomes revealed by quantitative analysis of cleavage products

23 June 2018

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Efficient identification of novel HLA-A(*)0201-presented cytotoxic T lymphocyte epitopes in the widely expressed tumor antigen PRAME by proteasome-mediated digestion analysis.

23 June 2018

1 reference

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Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity

23 June 2018

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Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor

23 June 2018

1 reference

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Safety and immunogenicity of the PRAME cancer immunotherapeutic in metastatic melanoma: results of a phase I dose escalation study.

23 June 2018

1 reference

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A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis.

31 August 2018

1 reference

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Prevalence and prognostic and predictive relevance of PRAME in breast cancer

31 August 2018

1 reference

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Detection and functional analysis of CD8+ T cells specific for PRAME: a target for T-cell therapy.

31 August 2018

1 reference

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Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface

31 August 2018

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Antigen processing by nardilysin and thimet oligopeptidase generates cytotoxic T cell epitopes

31 August 2018

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Rituximab, anti-CD20, induces in vivo cytokine release but does not impair ex vivo T-cell responses

3 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28628042

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI92335

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28628042%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference

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23 March 2020

1 reference