HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells (Q38719048)

7 June 2018

title

HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells (English)

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7 June 2018

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4

Herbert J Zeh

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7 June 2018

Michael T Lotze

5

object named as

Michael T Lotze

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7 June 2018

author name string

Shan Zhu

1

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7 June 2018

Qiuhong Zhang

2

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7 June 2018

Xiaofan Sun

3

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7 June 2018

Rui Kang

6

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7 June 2018

Daolin Tang

7

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7 June 2018

language of work or name

English

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publication date

27 January 2017

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7 June 2018

published in

Cancer Research

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7 June 2018

volume

77

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7 June 2018

issue

8

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7 June 2018

page(s)

2064-2077

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7 June 2018

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

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Identification of ACSL4 as a biomarker and contributor of ferroptosis

23 June 2018

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The ferroptosis inducer erastin enhances sensitivity of acute myeloid leukemia cells to chemotherapeutic agents

23 June 2018

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Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis.

23 June 2018

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Metallothionein-1G facilitates sorafenib resistance through inhibition of ferroptosis

23 June 2018

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Ferroptosis: process and function

23 June 2018

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Ferroptosis: Death by Lipid Peroxidation

23 June 2018

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Elevated GRP78 expression is associated with poor prognosis in patients with pancreatic cancer

23 June 2018

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Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells

23 June 2018

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Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

23 June 2018

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Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation

23 June 2018

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Glutaminolysis and Transferrin Regulate Ferroptosis

23 June 2018

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T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

23 June 2018

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Ferroptosis as a p53-mediated activity during tumour suppression

23 June 2018

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HSPB1 as a novel regulator of ferroptotic cancer cell death

23 June 2018

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Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

23 June 2018

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Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

23 June 2018

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Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis

23 June 2018

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GRP78 is a novel receptor initiating a vascular barrier protective response to oxidized phospholipids

23 June 2018

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Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

23 June 2018

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GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure.

23 June 2018

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Regulation of ferroptotic cancer cell death by GPX4

23 June 2018

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Ferroptosis: an iron-dependent form of nonapoptotic cell death

23 June 2018

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

23 June 2018

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Lipid peroxidation product 4-hydroxy-trans-2-nonenal causes endothelial activation by inducing endoplasmic reticulum stress

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

The xc- cystine/glutamate antiporter: a mediator of pancreatic cancer growth with a role in drug resistance

23 June 2018

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Structural basis for catalytic activity and enzyme polymerization of phospholipid hydroperoxide glutathione peroxidase-4 (GPx4)

23 June 2018

1 reference

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(-)-Epigallocatechin gallate overcomes resistance to etoposide-induced cell death by targeting the molecular chaperone glucose-regulated protein 78.

23 June 2018

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Mediators of endoplasmic reticulum stress-induced apoptosis

23 June 2018

1 reference

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GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development

23 June 2018

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Sulfasalazine: a review of its use in the management of rheumatoid arthritis

23 June 2018

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Endoplasmic reticulum stress induction of the Grp78/BiP promoter: activating mechanisms mediated by YY1 and its interactive chromatin modifiers.

23 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Transcriptional regulation of the Grp78 promoter by endoplasmic reticulum stress: role of TFII-I and its tyrosine phosphorylation.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Regulation of selenoprotein GPx4 expression and activity in human endothelial cells by fatty acids, cytokines and antioxidants

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Induction of Grp78/BiP by translational block: activation of the Grp78 promoter by ATF4 through and upstream ATF/CRE site independent of the endoplasmic reticulum stress elements

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Cysteine mutant of mammalian GPx4 rescues cell death induced by disruption of the wild-type selenoenzyme.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5392369

Phospholipid hydroperoxide glutathione peroxidase in various mouse organs during selenium deficiency and repletion

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28130223

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-16-1979

1 reference

7 June 2018

PMCID

5392369

1 reference

7 June 2018

PubMed ID

28130223

1 reference

7 June 2018