Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes (Q38717942)

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scientific article published on 17 January 2014

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English	Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes	scientific article published on 17 January 2014

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scholarly article

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5 September 2017

Assessment of chemical modifications of sites in the CDRs of recombinant antibodies: Susceptibility vs. functionality of critical quality attributes (English)

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5 September 2017

18

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1 June 2020

author name string

Markus Haberger

1

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Katrin Bomans

2

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1 June 2020

Katharina Diepold

3

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Michaela Hook

4

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Jana Gassner

5

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1 June 2020

Tilman Schlothauer

6

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Adrian Zwick

7

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1 June 2020

Christian Spick

8

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1 June 2020

Jochen Felix Kepert

9

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1 June 2020

Brigitte Hienz

10

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1 June 2020

Michael Wiedmann

11

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1 June 2020

Hermann Beck

12

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1 June 2020

Philipp Metzger

13

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1 June 2020

Michael Mølhøj

14

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1 June 2020

Constanze Knoblich

15

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1 June 2020

Ulla Grauschopf

16

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1 June 2020

Dietmar Reusch

17

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1 June 2020

publication date

17 January 2014

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5 September 2017

Monoclonal Antibodies

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1 June 2020

6

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1 June 2020

2

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1 June 2020

327-339

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Europe PubMed Central

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Developability studies before initiation of process development: improving manufacturability of monoclonal antibodies

1 reference

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Analytical FcRn affinity chromatography for functional characterization of monoclonal antibodies

1 reference

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Characterization of therapeutic antibodies and related products.

1 reference

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Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept

1 reference

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Progress in overcoming the chain association issue in bispecific heterodimeric IgG antibodies.

1 reference

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Simultaneous assessment of Asp isomerization and Asn deamidation in recombinant antibodies by LC-MS following incubation at elevated temperatures

1 reference

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Identification of potential sites for tryptophan oxidation in recombinant antibodies using tert-butylhydroperoxide and quantitative LC-MS

1 reference

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Assessing monoclonal antibody product quality attribute criticality through clinical studies

1 reference

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Mass spectrometric analysis of asparagine deamidation and aspartate isomerization in polypeptides

1 reference

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1 reference

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1 reference

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Heterogeneity of monoclonal antibodies revealed by charge-sensitive methods

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1 reference

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Formulation considerations for proteins susceptible to asparagine deamidation and aspartate isomerization.

1 reference

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1 reference

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Isomerization of an aspartic acid residue in the complementarity-determining regions of a recombinant antibody to human IgE: identification and effect on binding affinity.

1 reference

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Asparagine deamidation dependence on buffer type, pH, and temperature

1 reference

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

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1 reference

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Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3984323

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1 reference

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Identification of multiple sources of charge heterogeneity in a recombinant antibody.

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Comparison of methionine oxidation in thermal stability and chemically stressed samples of a fully human monoclonal antibody

1 reference

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Determination of protein oxidation by mass spectrometry and method transfer to quality control

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12 December 2020

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Identifiers

10.4161/MABS.27876

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24441081%20AND%20SRC:MED&resulttype=core&format=json

1 June 2020

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