RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma. (Q38709232)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28369725%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

title

RNA Polymerase I Inhibition with CX-5461 as a Novel Therapeutic Strategy to Target MYC in Multiple Myeloma (English)

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15 March 2020

13

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16

Robert Z Orlowski

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15 March 2020

author name string

Hans C Lee

1

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15 March 2020

Hua Wang

2

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15 March 2020

Veerabhadran Baladandayuthapani

3

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15 March 2020

Heather Lin

4

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15 March 2020

Jin He

5

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15 March 2020

Richard J Jones

6

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15 March 2020

Isere Kuiatse

7

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15 March 2020

Dongmin Gu

8

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Zhiqiang Wang

9

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15 March 2020

Wencai Ma

10

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15 March 2020

John Lim

11

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15 March 2020

Sean O'Brien

12

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Jing Yang

14

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15 March 2020

Richard E Davis

15

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15 March 2020

language of work or name

English

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publication date

1 April 2017

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British Journal of Haematology

15 March 2020

published in

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15 March 2020

volume

177

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15 March 2020

page(s)

80-94

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issue

1

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Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors.

15 March 2020

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27 July 2018

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Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma.

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Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development

27 July 2018

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Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

27 July 2018

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Loss of 1p and rearrangement of MYC are associated with progression of smouldering myeloma to myeloma: sequential analysis of a single case

27 July 2018

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Targeted inhibition of the immunoproteasome is a potent strategy against models of multiple myeloma that overcomes resistance to conventional drugs and nonspecific proteasome inhibitors

27 July 2018

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Reflecting on 25 years with MYC.

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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31 August 2018

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31 August 2018

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31 August 2018

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Contribution of p53 to metastasis

31 August 2018

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Translocations at 8q24 juxtapose MYC with genes that harbor superenhancers resulting in overexpression and poor prognosis in myeloma patients

31 August 2018

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Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma.

31 August 2018

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A targeting modality for destruction of RNA polymerase I that possesses anticancer activity.

31 August 2018

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Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells

31 August 2018

1 reference

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Continued improvement in survival in multiple myeloma: changes in early mortality and outcomes in older patients.

31 August 2018

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Ribosomal proteins L5 and L11 co-operatively inactivate c-Myc via RNA-induced silencing complex

31 August 2018

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MYC, metabolism, cell growth, and tumorigenesis.

31 August 2018

1 reference

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Addiction to c-MYC in multiple myeloma

31 August 2018

1 reference

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Long-term analysis of the IFM 99 trials for myeloma: cytogenetic abnormalities [t(4;14), del(17p), 1q gains] play a major role in defining long-term survival.

31 August 2018

1 reference

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Targeting RNA polymerase I with an oral small molecule CX-5461 inhibits ribosomal RNA synthesis and solid tumor growth.

31 August 2018

1 reference

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MYC as a regulator of ribosome biogenesis and protein synthesis

31 August 2018

1 reference

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Modelling Myc inhibition as a cancer therapy

31 August 2018

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AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies.

31 August 2018

1 reference

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Is ribosome synthesis controlled by pol I transcription?

31 August 2018

1 reference

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Clinical significance of TP53 mutation in myeloma

31 August 2018

1 reference

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The transcriptional program of a human B cell line in response to Myc

31 August 2018

1 reference

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KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

31 August 2018

1 reference

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Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5695568

1 October 2018

Identifiers

DOI

10.1111/BJH.14525

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28369725%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28369725%20AND%20SRC:MED&resulttype=core&format=json

15 March 2020

1 reference