Prevention of epilepsy: Should we be avoiding clinical trials? (Q38667129)

5 September 2017

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title

Prevention of epilepsy: Should we be avoiding clinical trials? (English)

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5 September 2017

Pavel Klein

1

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PubMed ID

28647441

5 September 2017

Ivana Tyrlikova

series ordinal

2

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5 September 2017

21 June 2017

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5 September 2017

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5 September 2017

72

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5 September 2017

188-194

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Prevalence of epilepsy in Rochester, Minnesota: 1940-1980.

5 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Infections, inflammation and epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Results of phase 2 safety and feasibility study of treatment with levetiracetam for prevention of posttraumatic epilepsy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Epilepsy after brain insult: targeting epileptogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

The challenge and promise of anti-epileptic therapy development in animal models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Pharmacological treatments for preventing epilepsy following traumatic head injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

A randomized, double-blind study of phenytoin for the prevention of post-traumatic seizures

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Valproate therapy for prevention of posttraumatic seizures: a randomized trial.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Antiepileptogenic effects of conventional anticonvulsants in the kindling model of epilespy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Alteration of long-lasting structural and functional effects of kainic acid in the hippocampus by brief treatment with phenobarbital

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Past and present definitions of epileptogenesis and its biomarkers

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Prevention or modification of epileptogenesis after brain insults: experimental approaches and translational research

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Posttraumatic Epilepsy: What's Contusion Got to Do With It?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Neural circuit mechanisms of post-traumatic epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Spontaneous epileptiform activity in rat neocortex after controlled cortical impact injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Finding a better drug for epilepsy: antiepileptogenesis targets.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Transient inhibition of TrkB kinase after status epilepticus prevents development of temporal lobe epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Expression of GABA receptor subunits in the hippocampus and thalamus after experimental traumatic brain injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Post-traumatic epilepsy: cellular mechanisms and implications for treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Zonisamide reduces the increase in 8-hydroxy-2'-deoxyguanosine levels formed during iron-induced epileptogenesis in the brains of rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Dehydroepiandrosterone's antiepileptic action in FeCl3-induced epileptogenesis involves upregulation of glutamate transporters

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Posttraumatic epilepsy: hemorrhage, free radicals and the molecular regulation of glutamate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Ceftriaxone treatment after traumatic brain injury restores expression of the glutamate transporter, GLT-1, reduces regional gliosis, and reduces post-traumatic seizures in the rat

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Cyclooxygenase-2 inhibitor, celecoxib, inhibits the altered hippocampal neurogenesis with attenuation of spontaneous recurrent seizures following pilocarpine-induced status epilepticus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Losartan prevents acquired epilepsy via TGF-β signaling suppression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Fingolimod (FTY720) inhibits neuroinflammation and attenuates spontaneous convulsions in lithium-pilocarpine induced status epilepticus in rat model.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Gabapentin decreases epileptiform discharges in a chronic model of neocortical trauma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Erythropoietin reduces epileptogenic processes following status epilepticus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Molecular alterations underlying epileptogenesis after prolonged febrile seizure and modulation by erythropoietin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Neuroprotective, neuroplastic, and neurobehavioral effects of daily treatment with levetiracetam in experimental traumatic brain injury.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Statin treatment reduces the risk of poststroke seizures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Identification of new epilepsy treatments: issues in preclinical methodology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Prevention of Epilepsy After Head Trauma: Do We Need New Drugs or a New Approach?

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Functional definition of seizure provides new insight into post-traumatic epileptogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Counterpoint to "what is an epileptic seizure?" by D'Ambrosio and Miller

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Toward an international initiative for traumatic brain injury research

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Progesterone for Acute Traumatic Brain Injury: A Systematic Review of Randomized Controlled Trials

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Erythropoietin in traumatic brain injury (EPO-TBI): a double-blind randomised controlled trial.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Clinical trials in head injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Searching for the ideal antiepileptogenic agent in experimental models: single treatment versus combinatorial treatment strategies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Single versus combinatorial therapies in status epilepticus: Novel data from preclinical models

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

A population-based study of seizures after traumatic brain injuries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Advances in the development of biomarkers for epilepsy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

EEG spike activity precedes epilepsy after kainate-induced status epilepticus

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Nonconvulsive seizures after traumatic brain injury are associated with hippocampal atrophy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Evolution of temporal and spectral dynamics of pathologic high-frequency oscillations (pHFOs) during epileptogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Physiological consequences of abnormal connectivity in a developmental epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

In vivo study indicating loss of intracortical inhibition in tumor-associated epilepsy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Genetic variation in neuronal glutamate transport genes and associations with posttraumatic seizure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Ictal onset patterns of local field potentials, high frequency oscillations, and unit activity in human mesial temporal lobe epilepsy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Imaging synaptic density in the living human brain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Human clinical trails in antiepileptogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

Analyzing risk factors for late posttraumatic seizures: a prospective, multicenter investigation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEBEH.2017.05.024

10.1016/J.YEBEH.2017.05.024

7 January 2021

Identifiers

DOI

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5 September 2017

1 reference

PubMed ID

28647441