Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States. (Q38609992)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28837809%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

title

Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States (English)

1 reference

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28 March 2020

10

1 reference

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28 March 2020

John Henry McDermott

15

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28 March 2020

Mahmoud Ghandi

22

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28 March 2020

Aviad Tsherniak

25

1 reference

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30

Levi A Garraway

1 reference

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28 March 2020

36

Pablo Tamayo

1 reference

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William C Hahn

1 reference

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28 March 2020

23

Francisca Vazquez

1 reference

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Jesse S Boehm

1 reference

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David A Barbie

1 reference

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28 March 2020

21

John Doench

1 reference

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28 March 2020

24

Barbara A Weir

1 reference

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28 March 2020

Russell William Jenkins

6

object named as

Russell W Jenkins

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28 March 2020

author name string

Jong Wook Kim

1

1 reference

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28 March 2020

Omar O Abudayyeh

2

1 reference

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28 March 2020

Huwate Yeerna

3

1 reference

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28 March 2020

Chen-Hsiang Yeang

4

1 reference

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28 March 2020

Michelle Stewart

5

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28 March 2020

Shunsuke Kitajima

7

1 reference

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28 March 2020

David J Konieczkowski

8

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28 March 2020

Kate Medetgul-Ernar

9

1 reference

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28 March 2020

Clarence Mah

11

1 reference

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28 March 2020

Stephanie Ting

12

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28 March 2020

Eliezer M Van Allen

13

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28 March 2020

Ofir Cohen

14

1 reference

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28 March 2020

Emily Damato

16

1 reference

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28 March 2020

Andrew J Aguirre

17

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28 March 2020

Jonathan Liang

18

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28 March 2020

Arthur Liberzon

19

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28 March 2020

Gabriella Alexe

20

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28 March 2020

Aravind Subramanian

26

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Karina Meneses-Cime

27

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28 March 2020

Jason Park

28

1 reference

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28 March 2020

Paul Clemons

29

1 reference

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28 March 2020

David Thomas

31

1 reference

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28 March 2020

Jill P Mesirov

35

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28 March 2020

language of work or name

English

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publication date

1 August 2017

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28 March 2020

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28 March 2020

volume

5

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28 March 2020

page(s)

105-118.e9

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issue

2

1 reference

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describes a project that uses

28 March 2020

Jupyter notebook file

1 reference

A combinatorial strategy for treating KRAS-mutant lung cancer

cites work

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Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.

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Targeting an IKBKE cytokine network impairs triple-negative breast cancer growth

31 August 2018

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PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies

31 August 2018

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Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

31 August 2018

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Sporadic early-onset colorectal cancer is a specific sub-type of cancer: a morphological, molecular and genetics study

31 August 2018

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KRAS and YAP1 converge to regulate EMT and tumor survival

31 August 2018

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A melanoma cell state distinction influences sensitivity to MAPK pathway inhibitors

31 August 2018

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31 August 2018

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Intrinsic resistance to MEK inhibition in KRAS mutant lung and colon cancer through transcriptional induction of ERBB3.

31 August 2018

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Inhibition of KRAS-driven tumorigenicity by interruption of an autocrine cytokine circuit.

31 August 2018

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Epithelial-to-mesenchymal transition rewires the molecular path to PI3K-dependent proliferation

31 August 2018

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Lung tumor NF-κB signaling promotes T cell-mediated immune surveillance

31 August 2018

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Lessons from the cancer genome

31 August 2018

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Meta-analysis of gene expression signatures defining the epithelial to mesenchymal transition during cancer progression

31 August 2018

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Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

31 August 2018

1 reference

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The transcriptional landscape and mutational profile of lung adenocarcinoma.

31 August 2018

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Cancer epigenetics: from mechanism to therapy

31 August 2018

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MicroSCALE screening reveals genetic modifiers of therapeutic response in melanoma

31 August 2018

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism

31 August 2018

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The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

31 August 2018

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Systematic identification of genomic markers of drug sensitivity in cancer cells

31 August 2018

1 reference

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TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

31 August 2018

1 reference

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Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR.

31 August 2018

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Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer

31 August 2018

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Molecular signatures database (MSigDB) 3.0.

31 August 2018

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Predicting relapse in patients with medulloblastoma by integrating evidence from clinical and genomic features

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer

31 August 2018

1 reference

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

31 August 2018

1 reference

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Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

31 August 2018

1 reference

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An oncogenic role for ETV1 in melanoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

A gene expression signature associated with "K-Ras addiction" reveals regulators of EMT and tumor cell survival

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

A genomic strategy to elucidate modules of oncogenic pathway signaling networks

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

(V600E)BRAF is associated with disabled feedback inhibition of RAF-MEK signaling and elevated transcriptional output of the pathway

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

Metagene projection for cross-platform, cross-species characterization of global transcriptional states

31 August 2018

1 reference

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A method for high-throughput gene expression signature analysis

31 August 2018

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Oncogenic pathway signatures in human cancers as a guide to targeted therapies

31 August 2018

1 reference

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FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5639711

Metagenes and molecular pattern discovery using matrix factorization

31 August 2018

1 reference

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Immortalization and transformation of primary human airway epithelial cells by gene transfer.

31 August 2018

1 reference

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Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells.

31 August 2018

1 reference

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Divergent gene regulation and growth effects by NF-κB in epithelial and mesenchymal cells of human skin

31 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28837809

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELS.2017.08.002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28837809%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28837809%20AND%20SRC:MED&resulttype=core&format=json

28 March 2020

1 reference