Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine (Q38598388)

4 September 2017

Modification of Astrocyte Metabolism as an Approach to the Treatment of Epilepsy: Triheptanoin and Acetyl-L-Carnitine (English)

1 reference

4 September 2017

0 references

Olav B Smeland

3

0 references

Haytham Eloqayli

object named as

Haytham Eloqayli

5

0 references

Karin Borges

object named as

Karin Borges

7

0 references

Ursula Sonnewald

8

object named as

Ursula Sonnewald

1 reference

4 September 2017

Mussie Ghezu Hadera

1

1 reference

4 September 2017

Tanya McDonald

2

1 reference

4 September 2017

Tore W Meisingset

4

1 reference

4 September 2017

Saied Jaradat

6

1 reference

4 September 2017

3 October 2015

1 reference

4 September 2017

Neurochemical Research

1 reference

4 September 2017

41

1 reference

4 September 2017

1-2

1 reference

4 September 2017

86-95

1 reference

https://scigraph.springernature.com/pub.10.1007/s11064-015-1728-5

4 September 2017

0 references

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Standards for epidemiologic studies and surveillance of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Is epilepsy a preventable disorder? New evidence from animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Mesial temporal lobe epilepsy: what have we learned?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Epilepsy surgery in children and adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

The efficacy of the ketogenic diet-1998: a prospective evaluation of intervention in 150 children

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Expression of glutamine synthetase and glutamate dehydrogenase in the latent phase and chronic phase in the kainate model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Pathogenesis and pharmacology of epilepsy in the lithium-pilocarpine model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Neuronal and glial pathological changes during epileptogenesis in the mouse pilocarpine model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Glucose transporter deficiency syndrome (GLUT1DS) and the ketogenic diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Triheptanoin for glucose transporter type I deficiency (G1D): modulation of human ictogenesis, cerebral metabolic rate, and cognitive indices by a food supplement

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Topography of interictal glucose hypometabolism in unilateral mesiotemporal epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Interictal metabolic anatomy of mesial temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Quantifying interictal metabolic activity in human temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Relationship between neuronal loss and interictal glucose metabolism during the chronic phase of the lithium-pilocarpine model of epilepsy in the immature and adult rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Metabolism is normal in astrocytes in chronically epileptic rats: a (13)C NMR study of neuronal-glial interactions in a model of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Dietary supplementation with acetyl-l-carnitine in seizure treatment of pentylenetetrazole kindled mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Amino acid content of epileptogenic human brain: Focal versus surrounding regions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Extracellular metabolites in the cortex and hippocampus of epileptic patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Glutamate-glutamine cycling in the epileptic human hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Glutamate receptors and transporters in genetic and acquired models of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Loss of glutamine synthetase in the human epileptogenic hippocampus: possible mechanism for raised extracellular glutamate in mesial temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

The GLT-1 (EAAT2; slc1a2) glutamate transporter is essential for glutamate homeostasis in the neocortex of the mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Changes in glial glutamate transporters in human epileptogenic hippocampus: inadequate explanation for high extracellular glutamate during seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Triheptanoin--a medium chain triglyceride with odd chain fatty acids: a new anaplerotic anticonvulsant treatment?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Functional changes in astroglial cells in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Glutamine Synthetase: Glial Localization in Brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Astrocytes in the epileptic brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

The role and control of the glyoxylate cycle in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

The relative significance of CO2-fixing enzymes in the metabolism of rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Pyruvate carboxylation in different model systems studied by (13)C MRS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Elimination and replenishment of tricarboxylic acid-cycle intermediates in myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Quantitative assessment of anaplerosis from propionate in pig heart in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Assessing the reversibility of the anaplerotic reactions of the propionyl-CoA pathway in heart and liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

The key role of anaplerosis and cataplerosis for citric acid cycle function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Medium chain fatty acid metabolism and energy expenditure: obesity treatment implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Parenteral and enteral metabolism of anaplerotic triheptanoin in normal rats. II. Effects on lipolysis, glucose production, and liver acyl-CoA profile

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Anticonvulsant effects of a triheptanoin diet in two mouse chronic seizure models

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Alterations of hippocampal glucose metabolism by even versus uneven medium chain triglycerides.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Triheptanoin reduces seizure susceptibility in a syndrome-specific mouse model of generalized epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Effects of short-term and long-term treatment with medium- and long-chain triglycerides ketogenic diet on cortical spreading depression in young rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Triheptanoin improves brain energy metabolism in patients with Huntington disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Dietary anaplerotic therapy improves peripheral tissue energy metabolism in patients with Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Pharmacokinetics of IV and oral acetyl-L-carnitine in a multiple dose regimen in patients with senile dementia of Alzheimer type.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Functional relevance of carnitine transporter OCTN2 to brain distribution of L-carnitine and acetyl-L-carnitine across the blood-brain barrier

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

High affinity carnitine transporters from OCTN family in neural cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Carnitine derivatives: clinical usefulness

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Mitochondrial beta-oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Acylcarnitines: role in brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Suppression of pentylenetetrazol-induced seizures by carnitine in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Aging brain: effect of acetyl-L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Acetyl-L-carnitine modulates glucose metabolism and stimulates glycogen synthesis in rat brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Chronic acetyl-L-carnitine alters brain energy metabolism and increases noradrenaline and serotonin content in healthy mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Excitotoxic damage, disrupted energy metabolism, and oxidative stress in the rat brain: antioxidant and neuroprotective effects of L-carnitine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Antioxidant and antiradical activities of L-carnitine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Ketogenic diet is antiepileptogenic in pentylenetetrazole kindled mice and decrease levels of N-acylethanolamines in hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Monitoring of ketogenic diet for carnitine metabolites by subcutaneous microdialysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Treatment of cardiomyopathy and rhabdomyolysis in long-chain fat oxidation disorders using an anaplerotic odd-chain triglyceride

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Triheptanoin supplementation to ketogenic diet curbs cognitive impairment in APP/PS1 mice used as a model of familial Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

A review of current evidence for acetyl-l-carnitine in the treatment of depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Carnitine esters prevent oxidative stress damage and energy depletion following transient forebrain ischaemia in the rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Association between cortical metabolite levels and clinical manifestations of migrainous aura: an MR-spectroscopy study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

Alternative medicine and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11064-015-1728-5

An astrocytic basis of epilepsy

21 January 2018

1 reference

12 December 2020

Acetyl-l-carnitine for dementia

1 reference

12 December 2020

Acetyl-l-carnitine versus placebo for migraine prophylaxis: A randomized, triple-blind, crossover study

1 reference

12 December 2020

Pharmacodynamic properties of N-dipropylacetic acid

1 reference

12 December 2020

Brain mitochondrial metabolic dysfunction and glutamate level reduction in the pilocarpine model of temporal lobe epilepsy in mice

1 reference

12 December 2020

Neuroprotection by acetyl-L-carnitine after traumatic injury to the immature rat brain

1 reference

12 December 2020

Mitochondrial compartmentation at the cellular level: astrocytes and neurons

1 reference

12 December 2020

Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways

1 reference

12 December 2020

Anaplerotic diet therapy in inherited metabolic disease: therapeutic potential

1 reference

12 December 2020

Triheptanoin in acute mouse seizure models

1 reference

12 December 2020

Limbic structures show altered glial-neuronal metabolism in the chronic phase of kainate induced epilepsy

1 reference

12 December 2020

Laboratory animal models of temporal lobe epilepsy.

1 reference

12 December 2020

Magnetic resonance spectroscopic imaging in temporal lobe epilepsy: neuronal dysfunction or cell loss?

1 reference

12 December 2020

Action of carnitine on long chain fatty acid oxidation by liver

1 reference

12 December 2020

Carnitine metabolism in the fasting rat

1 reference

12 December 2020

10.1007/S11064-015-1728-5

Identifiers

DOI

1 reference

Dimensions Publication ID

4 September 2017

0 references

1 reference