The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia (Q38560778)

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scientific article published on 05 August 2015

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English	The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia	scientific article published on 05 August 2015

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scholarly article

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Europe PubMed Central

4 September 2017

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Europe PubMed Central

The therapeutic potential of α7 nicotinic acetylcholine receptor (α7 nAChR) agonists for the treatment of the cognitive deficits associated with schizophrenia (English)

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Europe PubMed Central

4 September 2017

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Samuel Banister

2

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31 May 2020

Michael Kassiou

5

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31 May 2020

author name string

Corinne Beinat

1

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31 May 2020

Marco Herrera

3

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31 May 2020

Vivian Law

4

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31 May 2020

publication date

5 August 2015

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4 September 2017

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31 May 2020

29

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31 May 2020

7

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31 May 2020

529-542

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31 May 2020

https://scigraph.springernature.com/pub.10.1007/s40263-015-0260-0

0 references

Muscarinic receptors--characterization, coupling and function

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21 January 2018

Nicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system

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21 January 2018

Nicotinic receptors in the brain: correlating physiology with function

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21 January 2018

Presynaptic ionotropic receptors and the control of transmitter release.

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21 January 2018

Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain

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21 January 2018

Nicotinic alpha 7 receptors: synaptic options and downstream signaling in neurons

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21 January 2018

Nicotinic acetylcholine receptors and the regulation of neuronal signalling.

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21 January 2018

Neuronal nicotinic receptors: from structure to pathology

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21 January 2018

The diversity of subunit composition in nAChRs: evolutionary origins, physiologic and pharmacologic consequences

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21 January 2018

Nicotinic receptors at the amino acid level

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21 January 2018

Brain neuronal nicotinic receptors as new targets for drug discovery

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21 January 2018

Nicotine and carbamylcholine binding to nicotinic acetylcholine receptors as studied in AChBP crystal structures

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21 January 2018

Crystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.

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21 January 2018

Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

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21 January 2018

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system

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21 January 2018

The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia

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21 January 2018

The brain alpha7 nicotinic receptor may be an important therapeutic target for the treatment of Alzheimer's disease: studies with DMXBA (GTS-21).

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21 January 2018

Targeting brain α7 nicotinic acetylcholine receptors in Alzheimer's disease: rationale and current status

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21 January 2018

Schizophrenia: from phenomenology to neurobiology

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21 January 2018

Neuroscience. Deconstructing schizophrenia.

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21 January 2018

A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors

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21 January 2018

Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers.

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21 January 2018

α7 nicotinic acetylcholine receptor as a potential therapeutic target for schizophrenia.

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21 January 2018

Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus

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21 January 2018

Evidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia

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21 January 2018

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21 January 2018

Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine

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21 January 2018

Effects of typical and atypical antipsychotics and receptor selective compounds on acetylcholine efflux in the hippocampus of the rat.

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21 January 2018

Auditory P50 in schizophrenics on clozapine: improved gating parallels clinical improvement and changes in plasma 3-methoxy-4-hydroxyphenylglycol.

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21 January 2018

Effects of sound intensity on a midlatency evoked response to repeated auditory stimuli in schizophrenic and normal subjects.

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21 January 2018

Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications

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21 January 2018

DMXB, an alpha7 nicotinic agonist, normalizes auditory gating in isolation-reared rats

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21 January 2018

Initial phase 2 trial of a nicotinic agonist in schizophrenia

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21 January 2018

Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity

1 reference

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21 January 2018

Acetylcholine-dopamine interactions in the pathophysiology and treatment of CNS disorders.

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21 January 2018

Dual effects of nicotine on dopamine neurons mediated by different nicotinic receptor subtypes

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21 January 2018

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

1 reference

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21 January 2018

EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors

1 reference

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21 January 2018

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity rela

1 reference

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21 January 2018

Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists

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21 January 2018

Discovery of 4-(5-methyloxazolo[4,5-b]pyridin-2-yl)-1,4-diazabicyclo[3.2.2]nonane (CP-810,123), a novel alpha 7 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders in schizophrenia: synthesis, SAR development, and in vi

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21 January 2018

TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia

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21 January 2018

SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (1) binding and functional profile

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21 January 2018

Selective alpha7 nicotinic receptor activation by AZD0328 enhances cortical dopamine release and improves learning and attentional processes.

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21 January 2018

Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways

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21 January 2018

AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation

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21 January 2018

Allosteric alpha-7 nicotinic receptor modulation and P50 sensory gating in schizophrenia: a proof-of-mechanism study.

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21 January 2018

Effect of galantamine on the human alpha7 neuronal nicotinic acetylcholine receptor, the Torpedo nicotinic acetylcholine receptor and spontaneous cholinergic synaptic activity

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21 January 2018

Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia

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21 January 2018

A reversible model of the cognitive impairment associated with schizophrenia in monkeys: potential therapeutic effects of two nicotinic acetylcholine receptor agonists.

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21 January 2018

Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia

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21 January 2018

Normalizing effects of EVP-6124, an α-7 nicotinic partial agonist, on event-related potentials and cognition: a proof of concept, randomized trial in patients with schizophrenia

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21 January 2018

Safety and clinical effects of EVP-6124 in subjects with Alzheimer's disease currently or previously receiving an acetylcholinesterase inhibitor medication

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21 January 2018

RG3487, a novel nicotinic α7 receptor partial agonist, improves cognition and sensorimotor gating in rodents.

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21 January 2018

Effect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats

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21 January 2018

Drug development for Alzheimer's disease: where are we now and where are we headed?

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21 January 2018

A randomized, placebo-controlled study investigating the nicotinic α7 agonist, RG3487, for cognitive deficits in schizophrenia

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21 January 2018

Metabolism and disposition of a selective alpha(7) nicotinic acetylcholine receptor agonist in humans.

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21 January 2018

A randomized exploratory trial of an α-7 nicotinic receptor agonist (TC-5619) for cognitive enhancement in schizophrenia

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21 January 2018

The "two-headed" latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment

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21 January 2018

Pro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia.

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21 January 2018

Ultra-low exposure to α-7 nicotinic acetylcholine receptor partial agonists elicits an improvement in cognition that corresponds with an increase in α-7 receptor expression in rodents: implications for low dose clinical efficacy.

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21 January 2018

Immediate and sustained improvements in working memory after selective stimulation of α7 nicotinic acetylcholine receptors.

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21 January 2018

[3H]A-585539 [(1S,4S)-2,2-dimethyl-5-(6-phenylpyridazin-3-yl)-5-aza-2-azoniabicyclo[2.2.1]heptane], a novel high-affinity alpha7 neuronal nicotinic receptor agonist: radioligand binding characterization to rat and human brain

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21 January 2018

Preclinical characterization of A-582941: a novel alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties

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21 January 2018

Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations

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21 January 2018

Muscarinic and nicotinic acetylcholine receptor agonists and allosteric modulators for the treatment of schizophrenia

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21 January 2018

Distinct profiles of alpha7 nAChR positive allosteric modulation revealed by structurally diverse chemotypes

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21 January 2018

In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile

1 reference

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21 January 2018

A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization.

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21 January 2018

Targeting alpha-7 nicotinic neurotransmission in schizophrenia: a novel agonist strategy

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21 January 2018

Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors

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21 January 2018

Preclinical Characterization of A-582941: A Novel α7 Neuronal Nicotinic Receptor Agonist with Broad Spectrum Cognition-Enhancing Properties

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Review and management of clozapine side effects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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The pharmacology of latent inhibition as an animal model of schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic receptors as targets for therapeutic discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Genetic linkage to schizophrenia at chromosome 15q14

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

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Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia I: sensitivity, reliability, and validity

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Novel alpha7 nicotinic receptor isoforms and deficient cholinergic transcription in schizophrenia.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Clozapine decreases smoking in patients with chronic schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nicotinic acetylcholine receptors: an overview on drug discovery

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Diversity of nicotinic acetylcholine receptors in rat brain. V. alpha-Bungarotoxin-sensitive nicotinic receptors in olfactory bulb neurons and presynaptic modulation of glutamate release.

1 reference

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12 December 2020

based on heuristic

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Functional alpha7-containing nicotinic acetylcholine receptors localize to cell bodies and proximal dendrites in the rat substantia nigra pars reticulata

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Neuronal acetylcholine receptors with alpha7 subunits are concentrated on somatic spines for synaptic signaling in embryonic chick ciliary ganglia

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia, II: convergent/discriminant validity and diagnostic group comparisons.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AQW051, a novel and selective nicotinic acetylcholine receptor α7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Molecular cloning, functional properties, and distribution of rat brain alpha 7: a nicotinic cation channel highly permeable to calcium.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

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Nicotinic binding in rat brain: autoradiographic comparison of [3H]acetylcholine, [3H]nicotine, and [125I]-alpha-bungarotoxin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the nature of partial agonism in the nicotinic receptor superfamily

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repeated administration of alpha7 nicotinic acetylcholine receptor (nAChR) agonists, but not positive allosteric modulators, increases alpha7 nAChR levels in the brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/26242477

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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