Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy (Q38526844)

3 September 2017

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title

Integrated Akt/PKB signaling in immunomodulation and its potential role in cancer immunotherapy (English)

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3 September 2017

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3

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3 September 2017

7

Brian A Hemmings

1 reference

3 September 2017

Gongda Xue

1

1 reference

3 September 2017

Alfred Zippelius

2

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3 September 2017

Mario Mandalà

4

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3 September 2017

Fengyuan Tang

5

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3 September 2017

Daniela Massi

6

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3 September 2017

language of work or name

English

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publication date

11 June 2015

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Journal of the National Cancer Institute

3 September 2017

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3 September 2017

107

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3 September 2017

7

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The nuts and bolts of AGC protein kinases

3 September 2017

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Protein kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

TOR complex 2: a signaling pathway of its own.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Physiological roles of PKB/Akt isoforms in development and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PKB/AKT: functional insights from genetic models

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PI3K and cancer: lessons, challenges and opportunities

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PKB/Akt-dependent regulation of cell motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt/PKB-mediated phosphorylation of Twist1 promotes tumor metastasis via mediating cross-talk between PI3K/Akt and TGF-β signaling axes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Signaling interplay between transforming growth factor-β receptor and PI3K/AKT pathways in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

First-in-man clinical trial of the oral pan-AKT inhibitor MK-2206 in patients with advanced solid tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Interrogating two schedules of the AKT inhibitor MK-2206 in patients with advanced solid tumors incorporating novel pharmacodynamic and functional imaging biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Novel agents for multiple myeloma to overcome resistance in phase III clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Phase II study of perifosine and sorafenib dual-targeted therapy in patients with relapsed or refractory lymphoproliferative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Perifosine plus bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma previously treated with bortezomib: results of a multicenter phase I/II trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Clinical and translational studies of a phase II trial of the novel oral Akt inhibitor perifosine in relapsed or relapsed/refractory Waldenstrom's macroglobulinemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt inhibitors in clinical development for the treatment of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Regulation of thymocyte development through CD3. II. Expression of T cell receptor beta CD3 epsilon and maturation to the CD4+8+ stage are highly correlated in individual thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Regulation of thymocyte development through CD3. I. Timepoint of ligation of CD3 epsilon determines clonal deletion or induction of developmental program

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

HES1 opposes a PTEN-dependent check on survival, differentiation, and proliferation of TCRβ-selected mouse thymocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Deletion of β-catenin impairs T cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Cooperating pre-T-cell receptor and TCF-1-dependent signals ensure thymocyte survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Cyclic adenosine 5'-monophosphate response element binding protein plays a central role in mediating proliferation and differentiation downstream of the pre-TCR complex in developing thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Protein kinase B regulates T lymphocyte survival, nuclear factor kappaB activation, and Bcl-X(L) levels in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Kruppel-like factor 2 regulates thymocyte and T-cell migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Foxo: in command of T lymphocyte homeostasis and tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Three chemokine receptors cooperatively regulate homing of hematopoietic progenitors to the embryonic mouse thymus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt1 and Akt2 promote peripheral B-cell maturation and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Role of PI3K in the generation and survival of B cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

FOXO1 transcription factor: a critical effector of the PI3K-AKT axis in B-cell development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PI3K-PKB hyperactivation augments human plasmacytoid dendritic cell development and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Human CD34-derived myeloid dendritic cell development requires intact phosphatidylinositol 3-kinase-protein kinase B-mammalian target of rapamycin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Leptin exerts an anti-apoptotic effect on human dendritic cells via the PI3K-Akt signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

An essential role for Akt1 in dendritic cell function and tumor immunotherapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PI3K/Akt regulates survival during differentiation of human macrophages by maintaining NF-κB-dependent expression of antiapoptotic Bcl-xL.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt isoforms differentially regulate neutrophil functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Making new contacts: the mTOR network in metabolism and signalling crosstalk

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The CD28 signaling pathway regulates glucose metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

FOXO3 regulates CD8 T cell memory by T cell-intrinsic mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The AKT-mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Forkhead-box transcription factors and their role in the immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Foxo transcription factors control regulatory T cell development and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8(+) T cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Transcription factors Foxo3a and Foxo1 couple the E3 ligase Cbl-b to the induction of Foxp3 expression in induced regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Novel Foxo1-dependent transcriptional programs control T(reg) cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Antagonizing dopamine D1-like receptor inhibits Th17 cell differentiation: preventive and therapeutic effects on experimental autoimmune encephalomyelitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Tumor stroma and regulation of cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt stimulates aerobic glycolysis in cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Fibroblast heterogeneity in the cancer wound

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Cancer-associated fibroblasts drive the progression of metastasis through both paracrine and mechanical pressure on cancer tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Accessories to the crime: functions of cells recruited to the tumor microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The great escape: when cancer cells hijack the genes for chemotaxis and motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Phosphoinositide 3-kinase: a key biochemical signal for cell migration in response to chemokines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Crosstalk in NF-κB signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt-mediated regulation of NFkappaB and the essentialness of NFkappaB for the oncogenicity of PI3K and Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

CCR6 regulates the migration of inflammatory and regulatory T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

MicroRNA-150 inhibits tumor invasion and metastasis by targeting the chemokine receptor CCR6, in advanced cutaneous T-cell lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Hypoxia transcriptionally induces macrophage-inflammatory protein-3alpha/CCL-20 in primary human mononuclear phagocytes through nuclear factor (NF)-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Human macrophage inflammatory protein-3alpha/CCL20/LARC/Exodus/SCYA20 is transcriptionally upregulated by tumor necrosis factor-alpha via a non-standard NF-kappaB site

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Transcriptional mechanisms regulating alveolar epithelial cell-specific CCL5 secretion in pulmonary tuberculosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Inducible expression of a Th2-type CC chemokine thymus- and activation-regulated chemokine by human bronchial epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Inflammation linking EMT and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PTEN loss mediated Akt activation promotes prostate tumor growth and metastasis via CXCL12/CXCR4 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Up-regulation of the chemokine receptor CCR7 in classical but not in lymphocyte-predominant Hodgkin disease correlates with distinct dissemination of neoplastic cells in lymphoid organs

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The immune contexture in human tumours: impact on clinical outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Lymphocytes in cancer development: polarization towards pro-tumor immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Tumour-educated macrophages promote tumour progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Macrophage diversity enhances tumor progression and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Tumor-associated neutrophils: new targets for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Mechanisms of immune evasion by tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Molecular regulation of T-cell anergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Tumor escape mechanism governed by myeloid-derived suppressor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Natural innate and adaptive immunity to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Paradoxical roles of the immune system during cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PD-1 and its ligands in tolerance and immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

21 January 2018

The B7 family revisited

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Molecular pathways: next-generation immunotherapy--inhibiting programmed death-ligand 1 and programmed death-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The PI3' kinase pathway in interferon signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PTEN loss increases PD-L1 protein expression and affects the correlation between PD-L1 expression and clinical parameters in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PD-L1 expression in triple-negative breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

PI(3) kinase is associated with a mechanism of immunoresistance in breast and prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Effects of MAPK and PI3K pathways on PD-L1 expression in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Selective inhibition of regulatory T cells by targeting the PI3K-Akt pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

TGF-β-miR-34a-CCL22 signaling-induced Treg cell recruitment promotes venous metastases of HBV-positive hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Tumor-associated macrophages: from mechanisms to therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Improving chemoradiation efficacy by PI3-K/AKT inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Activation of Akt as a mechanism for tumor immune evasion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Signal integration by Akt regulates CD8 T cell effector and memory differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

MHC class II engagement by its ligand LAG-3 (CD223) contributes to melanoma resistance to apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Induction of granzyme B expression in T-cell receptor/CD28-stimulated human regulatory T cells is suppressed by inhibitors of the PI3K-mTOR pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Vemurafenib reverses immunosuppression by myeloid derived suppressor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Selective BRAF inhibitors induce marked T-cell infiltration into human metastatic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

AEBP1 upregulation confers acquired resistance to BRAF (V600E) inhibition in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt directly regulates focal adhesion kinase through association and serine phosphorylation: implication for pressure-induced colon cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Protein phosphatase 1 binds to phospho-Ser-1394 of the macrophage-stimulating protein receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

CD34 Antigen: Determination of Specific Sites of Phosphorylation In Vitro and In Vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FJNCI%2FDJV171

21 January 2018

Identifiers

DOI

10.1093/JNCI/DJV171

1 reference

3 September 2017

1 reference