Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney. (Q38482641)

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7 November 2019

title

Esterification of cidofovir with alkoxyalkanols increases oral bioavailability and diminishes drug accumulation in kidney (English)

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7 November 2019

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7

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7 November 2019

author name string

Stephanie L Ciesla

1

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7 November 2019

Julissa Trahan

2

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7 November 2019

W Brad Wan

3

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7 November 2019

James R Beadle

4

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Kathy A Aldern

5

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George R Painter

6

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publication date

1 August 2003

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7 November 2019

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7 November 2019

volume

59

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7 November 2019

page(s)

163-171

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7 November 2019

issue

3

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Increased antiviral activity of 1-O-hexadecyloxypropyl-[2-(14)C]cidofovir in MRC-5 human lung fibroblasts is explained by unique cellular uptake and metabolism.

7 November 2019

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Alkylthioglycerol prodrugs of foscarnet: synthesis, oral bioavailability and structure-activity studies in human cytomegalovirus-, herpes simplex virus type 1- and human immunodeficiency virus type 1-infected cells

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Synthesis and antiviral evaluation of 1-O-hexadecylpropanediol-3-P-acyclovir: efficacy against HSV-1 infection in mice

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Alkoxyalkyl esters of cidofovir and cyclic cidofovir exhibit multiple-log enhancement of antiviral activity against cytomegalovirus and herpesvirus replication in vitro

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Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge

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Kinetic analysis of the interaction between the diphosphate of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, ddCTP, AZTTP, and FIAUTP with human DNA polymerases beta and gamma

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Cidofovir in the treatment of poxvirus infections

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Efficacy of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine for the treatment of lethal vaccinia virus infections in severe combined immune deficiency (SCID) mice

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Antiviral activity of phosphonylmethoxyalkyl derivatives of purine and pyrimidines

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7 January 2021

Smallpox as a Biological Weapon

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Enhanced oral absorption and antiviral activity of 1-O-octadecyl-sn-glycero-3-phospho-acyclovir and related compounds in hepatitis B virus infection, in vitro

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7 January 2021

Antiviral activities of oral 1-O-hexadecylpropanediol-3-phosphoacyclovir and acyclovir in woodchucks with chronic woodchuck hepatitis virus infection

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7 January 2021

Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox.

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7 January 2021

Enhanced inhibition of orthopoxvirus replication in vitro by alkoxyalkyl esters of cidofovir and cyclic cidofovir

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7 January 2021

Intravenous cidofovir for peripheral cytomegalovirus retinitis in patients with AIDS. A randomized, controlled trial

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7 January 2021

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7 January 2021

Parenteral cidofovir for cytomegalovirus retinitis in patients with AIDS: the HPMPC peripheral cytomegalovirus retinitis trial. A randomized, controlled trial. Studies of Ocular complications of AIDS Research Group in Collaboration with the AIDS Cli

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7 January 2021

Pharmacokinetics, safety and bioavailability of HPMPC (cidofovir) in human immunodeficiency virus-infected subjects

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7 January 2021

Kinetic analysis of the interaction of cidofovir diphosphate with human cytomegalovirus DNA polymerase

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7 January 2021

10.1016/S0166-3542(03)00110-4

Identifiers

DOI

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7 November 2019

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