Regulation of gene expression by CAR: an update (Q38481059)

3 September 2017

1 reference

title

Regulation of gene expression by CAR: an update (English)

1 reference

3 September 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

author name string

Kaoru Kobayashi

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Mari Hashimoto

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Masahiko Negishi

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

publication date

16 May 2015

1 reference

3 September 2017

Archives of Toxicology

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

volume

89

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

page(s)

1045-1055

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s00204-015-1522-9

11 June 2020

exact match

0 references

cites work

Coordinated regulation of hepatic phase I and II drug-metabolizing genes and transporters using AhR-, CAR-, PXR-, PPARα-, and Nrf2-null mice

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Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).

21 January 2018

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A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

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CCAAT/enhancer-binding protein alpha (C/EBPalpha) and hepatocyte nuclear factor 4alpha (HNF4alpha) synergistically cooperate with constitutive androstane receptor to transactivate the human cytochrome P450 2B6 (CYP2B6) gene: application to the devel

21 January 2018

1 reference

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Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

1 reference

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A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression

21 January 2018

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Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter

21 January 2018

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Human constitutive androstane receptor mediated methotrexate induction of human dehydroepiandrosterone sulfotransferase (hSULT2A1).

21 January 2018

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The nuclear receptor CAR modulates alcohol-induced liver injury

21 January 2018

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SRC-3 is required for CAR-regulated hepatocyte proliferation and drug metabolism

21 January 2018

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The cyp2e1-humanized transgenic mouse: role of cyp2e1 in acetaminophen hepatotoxicity

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Is phenobarbital carcinogenic? A follow-up of 8078 epileptics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Di(2-ethylhexyl) phthalate is a highly potent agonist for the human constitutive androstane receptor splice variant CAR2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Regulation of constitutive androstane receptor and its target genes by fasting, cAMP, hepatocyte nuclear factor alpha, and the coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Protein serine/threonine phosphatase inhibitors suppress phenobarbital-induced Cyp2b10 gene transcription in mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Serine 202 regulates the nuclear translocation of constitutive active/androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

21 January 2018

1 reference

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Novel cell-based reporter assay system using epitope-tagged protein for the identification of agonistic ligands of constitutive androstane receptor (CAR).

21 January 2018

1 reference

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Nuclear receptor CAR requires early growth response 1 to activate the human cytochrome P450 2B6 gene

21 January 2018

1 reference

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Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Transcription factors and coactivators controlling nutrient and hormonal regulation of hepatic gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Molecular mechanism investigation of phenobarbital-induced serum cholesterol elevation in rat livers by microarray analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Nuclear receptors CAR and PXR cross talk with FOXO1 to regulate genes that encode drug-metabolizing and gluconeogenic enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Localization of the nuclear receptor CAR at the cell membrane of mouse liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Extracellular signal-regulated kinase is an endogenous signal retaining the nuclear constitutive active/androstane receptor (CAR) in the cytoplasm of mouse primary hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Lack of effect of hepatic enzyme induction on metabolic control in patients with type 2 (non-insulin-dependent) diabetes

21 January 2018

1 reference

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Use of comprehensive screening methods to detect selective human CAR activators.

21 January 2018

1 reference

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Cancer incidence among patients using antiepileptic drugs: a long-term follow-up of 28,000 patients.

21 January 2018

1 reference

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The orphan nuclear receptor DAX-1 functions as a potent corepressor of the constitutive androstane receptor (NR1I3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein

21 January 2018

1 reference

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The aldo-keto reductase Akr1b7 gene is a common transcriptional target of xenobiotic receptors pregnane X receptor and constitutive androstane receptor

21 January 2018

1 reference

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Identification of novel activators of constitutive androstane receptor from FDA-approved drugs by integrated computational and biological approaches

21 January 2018

1 reference

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Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Activation of the constitutive androstane receptor decreases HDL in wild-type and human apoA-I transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Functional inhibitory cross-talk between constitutive androstane receptor and hepatic nuclear factor-4 in hepatic lipid/glucose metabolism is mediated by competition for binding to the DR1 motif and to the common coactivators, GRIP-1 and PGC-1alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

A prospective, randomized trial of phenytoin in nonepileptic subjects with reduced HDL cholesterol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Dephosphorylation of threonine 38 is required for nuclear translocation and activation of human xenobiotic receptor CAR (NR1I3).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Active ERK1/2 protein interacts with the phosphorylated nuclear constitutive active/androstane receptor (CAR; NR1I3), repressing dephosphorylation and sequestering CAR in the cytoplasm

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Effect of CAR activation on selected metabolic pathways in normal and hyperlipidemic mouse livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Tumor formation in liver of conditional β-catenin-deficient mice exposed to a diethylnitrosamine/phenobarbital tumor promotion regimen

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

p38 Mitogen-activated protein kinase regulates nuclear receptor CAR that activates the CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Constitutive androstane receptor activation decreases plasma apolipoprotein B-containing lipoproteins and atherosclerosis in low-density lipoprotein receptor-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Acetaminophen modulates P-glycoprotein functional expression at the blood-brain barrier by a constitutive androstane receptor-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Phenobarbital response elements of cytochrome P450 genes and nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

PPP1R16A, the membrane subunit of protein phosphatase 1beta, signals nuclear translocation of the nuclear receptor constitutive active/androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting P

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Novel CAR-mediated mechanism for synergistic activation of two distinct elements within the human cytochrome P450 2B6 gene in HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Coordinated regulation of nuclear receptor CAR by CCRP/DNAJC7, HSP70 and the ubiquitin-proteasome system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Regulation of tissue-specific carboxylesterase expression by pregnane x receptor and constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The antiapoptotic factor growth arrest and DNA-damage-inducible 45 beta regulates the nuclear receptor constitutive active/androstane receptor-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The role of the nuclear receptor CAR as a coordinate regulator of hepatic gene expression in defense against chemical toxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Metformin represses drug-induced expression of CYP2B6 by modulating the constitutive androstane receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Identification of the nuclear receptor CAR:HSP90 complex in mouse liver and recruitment of protein phosphatase 2A in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Constitutive androstane receptor transcriptionally activates human CYP1A1 and CYP1A2 genes through a common regulatory element in the 5'-flanking region

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00204-015-1522-9

10.1007/S00204-015-1522-9

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25975989%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

11 June 2020

1008597065

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Fatcat ID

release_ie7s3or6dvdbnndzk665x5fzbi

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https://api.fatcat.wiki/v0/release/ie7s3or6dvdbnndzk665x5fzbi

mapped directly with Wikidata item

24 November 2022

based on heuristic

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