Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation. (Q38459448)

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scientific article published on 16 August 2012

Language	Label	Description	Also known as
English	Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation.	scientific article published on 16 August 2012

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scholarly article

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11 February 2020

Regulating the response to targeted MEK inhibition in melanoma: enhancing apoptosis in NRAS- and BRAF-mutant melanoma cells with Wnt/β-catenin activation (English)

1 reference

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11 February 2020

Randall T. Moon

5

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11 February 2020

author name string

William H Conrad

1

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11 February 2020

Reyna D Swift

2

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11 February 2020

Travis L Biechele

3

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11 February 2020

Rima M Kulikauskas

4

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11 February 2020

Andy J Chien

6

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11 February 2020

publication date

16 August 2012

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11 February 2020

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11 February 2020

11

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11 February 2020

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11 February 2020

3724-3730

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11 February 2020

A seven-marker signature and clinical outcome in malignant melanoma: a large-scale tissue-microarray study with two independent patient cohorts

1 reference

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6 September 2017

Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib

1 reference

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6 September 2017

Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.

1 reference

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6 September 2017

The BRAF(V600E) causes widespread alterations in gene methylation in the genome of melanoma cells

1 reference

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6 September 2017

β-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas

1 reference

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6 September 2017

NUAK2: an emerging acral melanoma oncogene

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6 September 2017

Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

1 reference

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6 September 2017

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

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6 September 2017

Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers

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6 September 2017

RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

1 reference

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Annual report to the nation on the status of cancer, 1975-2007, featuring tumors of the brain and other nervous system

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6 September 2017

The ubiquitin-specific protease USP34 regulates axin stability and Wnt/β-catenin signaling

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6 September 2017

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling

1 reference

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6 September 2017

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

1 reference

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6 September 2017

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma

1 reference

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6 September 2017

Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation

1 reference

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6 September 2017

A Wnt survival guide: from flies to human disease.

1 reference

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6 September 2017

Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

SUMOylation target sites at the C terminus protect Axin from ubiquitination and confer protein stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

The Catalogue of Somatic Mutations in Cancer (COSMIC)

1 reference

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6 September 2017

Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

The transcription network regulating melanocyte development and melanoma

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

The Roles of APC and Axin Derived from Experimental and Theoretical Analysis of the Wnt Pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Beta-catenin in the melanocyte lineage

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

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Environmental signals and cell fate specification in premigratory neural crest

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6 September 2017

Direct regulation of nacre, a zebrafish MITF homolog required for pigment cell formation, by the Wnt pathway.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Wnt-induced dephosphorylation of axin releases beta-catenin from the axin complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Frequent nuclear/cytoplasmic localization of beta-catenin without exon 3 mutations in malignant melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

Control of neural crest cell fate by the Wnt signalling pathway.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

6 September 2017

PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

14 September 2017

RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models

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14 September 2017

Reduced beta-catenin expression in the cytoplasm of advanced-stage superficial spreading malignant melanoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3495814

14 September 2017

Cytoplasmic and nuclear accumulation of beta-catenin is rarely caused by CTNNB1 exon 3 mutations in cutaneous malignant melanoma

1 reference

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31 August 2018

1 reference

https://api.crossref.org/works/10.4161%2FCC.21645

21 January 2018

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/22895053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Loss of beta-catenin expression associated with disease progression in malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22895053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mutations in exon 3 of the β-catenin gene are rare in melanoma cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/22895053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of P-cadherin, beta-catenin, and Wnt5a/frizzled for progression of melanocytic tumors and prognosis in cutaneous melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/22895053

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.4161/CC.21645

1 reference

Europe PubMed Central

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11 February 2020

1 reference

Europe PubMed Central

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11 February 2020

1 reference

Europe PubMed Central

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11 February 2020

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