The protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro (Q38443998)

3 September 2017

The protein kinase 2 inhibitor CX-4945 regulates osteoclast and osteoblast differentiation in vitro (English)

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3 September 2017

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You Hwa Son

1

1 reference

PMCID

3887940

3 September 2017

Seong Hee Moon

series ordinal

2

1 reference

PMCID

3887940

3 September 2017

Jiyeon Kim

series ordinal

3

1 reference

3 September 2017

22 October 2013

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3 September 2017

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3 September 2017

36

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3 September 2017

5

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3 September 2017

417-423

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https://scigraph.springernature.com/pub.10.1007/s10059-013-0184-9

3 September 2017

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cites work

Chemical proteomics and functional proteomics strategies for protein kinase inhibitor validation and protein kinase substrate identification: applications to protein kinase CK2.

1 reference

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Crowdsourcing 101: a few basics to make you the leader of the pack

6 September 2017

1 reference

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Fisetin Inhibits Osteoclast Differentiation via Downregulation of p38 and c-Fos-NFATc1 Signaling Pathways

6 September 2017

1 reference

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Protein kinase CK2 inhibitors: a patent review

6 September 2017

1 reference

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The transmembrane adaptor protein, linker for activation of T cells (LAT), regulates RANKL-induced osteoclast differentiation

6 September 2017

1 reference

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Akt induces osteoclast differentiation through regulating the GSK3β/NFATc1 signaling cascade

6 September 2017

1 reference

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Pre-clinical characterization of CX-4945, a potent and selective small molecule inhibitor of CK2 for the treatment of cancer

6 September 2017

1 reference

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ATP site-directed inhibitors of protein kinase CK2: an update

6 September 2017

1 reference

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Discovery and SAR of 5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid (CX-4945), the first clinical stage inhibitor of protein kinase CK2 for the treatment of cancer

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

CX-4945, an orally bioavailable selective inhibitor of protein kinase CK2, inhibits prosurvival and angiogenic signaling and exhibits antitumor efficacy

6 September 2017

1 reference

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Casein kinase 2 beta-subunit is a regulator of bone morphogenetic protein 2 signaling

6 September 2017

1 reference

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New protein kinase CK2 inhibitors: jumping out of the catalytic box.

6 September 2017

1 reference

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The selectivity of inhibitors of protein kinase CK2: an update

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

The molecular understanding of osteoclast differentiation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Simultaneous gene transfer of bone morphogenetic protein (BMP) -2 and BMP-7 by in vivo electroporation induces rapid bone formation and BMP-4 expression

6 September 2017

1 reference

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Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Drug repositioning: identifying and developing new uses for existing drugs

6 September 2017

1 reference

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Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Joining the cell survival squad: an emerging role for protein kinase CK2.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Nuclear matrix and protein kinase CK2 signaling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Protein kinase CK2 and its role in cellular proliferation, development and pathology

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Protein kinases. 4. Protein kinase CK2: an enzyme with multiple substrates and a puzzling regulation

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Expression, purification and osteogenic bioactivity of recombinant human BMP-4, -9, -10, -11 and -14.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Protein kinase CK2 phosphorylates and upregulates Akt/PKB.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Inhibition of CK2 binding to BMPRIa induces C2C12 differentiation into osteoblasts and adipocytes.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

CK2 Is a component of the KSR1 scaffold complex that contributes to Raf kinase activation

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Relationship between collagen synthesis and expression of the osteoblast phenotype in MC3T3-E1 cells

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Pharmacokinetic characterization of CK2 inhibitor CX-4945.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Druggability of the CK2 inhibitor CX-4945 as an anticancer drug and beyond.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Tanshinone IIA enhances BMP-2-stimulated commitment of C2C12 cells into osteoblasts via p38 activation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

2-Dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole: a novel powerful and selective inhibitor of protein kinase CK2.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2').

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3887940

RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10059-013-0184-9

c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10059-013-0184-9

Bone morphogenetic protein 2 (BMP-2) enhances BMP-3, BMP-4, and bone cell differentiation marker gene expression during the induction of mineralized bone matrix formation in cultures of fetal rat calvarial osteoblasts

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24293011

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Prospects for productivity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24293011

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1007/S10059-013-0184-9

1 reference

3 September 2017

1 reference

3 September 2017

1 reference

PMCID

3887940