Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease (Q38418718)

2 September 2017

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title

Vascular endothelial growth factors: multitasking functionality in metabolism, health and disease (English)

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2 September 2017

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4

Darren C Tomlinson

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Michael Harrison

3

Michael A Harrison

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Gina Smith

1

Gina A Smith

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Sreenivasan Ponnambalam

6

Sreenivasan Ponnambalam

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Stephen Wheatcroft

5

Stephen B Wheatcroft

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PubMed ID

25868665

2 September 2017

Gareth William Fearnley

Gareth W Fearnley

2

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publication date

14 April 2015

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Journal of Inherited Metabolic Disease

2 September 2017

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2 September 2017

38

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2 September 2017

4

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2 September 2017

753-763

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https://scigraph.springernature.com/pub.10.1007/s10545-015-9838-4

2 September 2017

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cites work

ApoB-containing lipoproteins regulate angiogenesis by modulating expression of VEGF receptor 1.

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Association of the VEGF gene polymorphism with diabetic retinopathy in type 2 diabetes patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Activation of vascular endothelial growth factor receptor-1 sustains angiogenesis and Bcl-2 expression via the phosphatidylinositol 3-kinase pathway in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Regulation of cancer cell metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Angiogenesis in life, disease and medicine

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Molecular mechanisms and clinical applications of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Branching morphogenesis and antiangiogenesis candidates: tip cells lead the way.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Role of growth factors in diabetic kidney disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Endothelial cells and VEGF in vascular development

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Role of endothelial cell metabolism in vessel sprouting.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Role of PFKFB3-driven glycolysis in vessel sprouting

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Lactate activates HIF-1 in oxidative but not in Warburg-phenotype human tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Control of vessel sprouting by genetic and metabolic determinants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Control of angiogenesis by AIBP-mediated cholesterol efflux.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGF-A isoforms differentially regulate ATF-2-dependent VCAM-1 gene expression and endothelial-leukocyte interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Binding to the extracellular matrix and proteolytic processing: two key mechanisms regulating vascular endothelial growth factor action

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Angiogenesis as a therapeutic target

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Amelioration of long-term renal changes in obese type 2 diabetic mice by a neutralizing vascular endothelial growth factor antibody

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Structure-function analysis of VEGF receptor activation and the role of coreceptors in angiogenic signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Vascular endothelial growth factor B controls endothelial fatty acid uptake.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGF gene polymorphisms and susceptibility to rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

The Shb adaptor protein causes Src-dependent cell spreading and activation of focal adhesion kinase in murine brain endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Metabolism: Sweet enticements to move

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

LDL attenuates VEGF-induced angiogenesis via mechanisms involving VEGFR2 internalization and degradation following endosome-trans-Golgi network trafficking.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Phosphorylation of Tyr1214 within VEGFR-2 triggers the recruitment of Nck and activation of Fyn leading to SAPK2/p38 activation and endothelial cell migration in response to VEGF

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Autocrine VEGF signaling is required for vascular homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Reevaluation of the role of VEGF-B suggests a restricted role in the revascularization of the ischemic myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Metabolic flux and the regulation of mammalian cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

von Hippel-Lindau disease: a clinical and scientific review

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Galectin-3 protein modulates cell surface expression and activation of vascular endothelial growth factor receptor 2 in human endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGFR1 receptor tyrosine kinase localization to the Golgi apparatus is calcium-dependent

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Glucose 6-phosphate dehydrogenase is regulated through c-Src-mediated tyrosine phosphorylation in endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGFR-1 and VEGFR-2: two non-identical twins with a unique physiognomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Protein kinase C regulates FLT1 abundance and stimulates its cleavage in vascular endothelial cells with the release of a soluble PlGF/VEGF antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Vascular endothelial growth factor (VEGF) signaling in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor receptor 2 to activate phosphoinositide 3-kinase/Akt and promote angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

IL-17 increased the production of vascular endothelial growth factor in rheumatoid arthritis synoviocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Lipid metabolism in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Increased vascular endothelial growth factor expression but impaired vascular endothelial growth factor receptor signaling in the myocardium of type 2 diabetic patients with chronic coronary heart disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Why AMD is a disease of ageing and not of development: mechanisms and insights

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Inhibition of aldose reductase prevents angiogenesis in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGF/SDF-1 promotes cardiac stem cell mobilization and myocardial repair in the infarcted heart

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

The molecular basis of VEGFR-1 signal transduction pathways in primary human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Diabetes mellitus activates signal transduction pathways resulting in vascular endothelial growth factor resistance of human monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Hypoxia differentially regulates VEGFR1 and VEGFR2 levels and alters intracellular signaling and cell migration in endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

The VEGF +405 CC promoter polymorphism is associated with an impaired prognosis in patients with chronic heart failure: a MERIT-HF substudy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGF resistance as a molecular basis to explain the angiogenesis paradox in diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

A ligand-independent VEGFR2 signaling pathway limits angiogenic responses in diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

De novo lipogenesis maintains vascular homeostasis through endothelial nitric-oxide synthase (eNOS) palmitoylation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Impaired acute collateral recruitment as a possible mechanism for increased cardiac adverse events in patients with diabetes mellitus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Enhancement of glucose transporter expression of brain endothelial cells by vascular endothelial growth factor derived from glioma exposed to hypoxia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

VEGF Polymorphisms Are Associated with Severity of Diabetic Retinopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Cardiac Stem Cells Possess Growth Factor-Receptor Systems That After Activation Regenerate the Infarcted Myocardium, Improving Ventricular Function and Long-Term Survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Association of VEGF Gene Polymorphisms with Diabetic Retinopathy in a South Indian Cohort

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Multiple Variants in Vascular Endothelial Growth Factor (VEGFA) Are Risk Factors for Time to Severe Retinopathy in Type 1 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10545-015-9838-4

Angiogenesis, arteriogenesis, and diabetes: paradigm reassessed?

21 January 2018

1 reference

12 December 2020

Aldose reductase, oxidative stress, and diabetic mellitus

1 reference

12 December 2020

A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes

1 reference

12 December 2020

Signal transduction by vascular endothelial growth factor receptors

1 reference

12 December 2020

Vascular dysfunction in diabetes mellitus

1 reference

12 December 2020

Vascular endothelial growth factor levels in vitreous and serum of patients with either proliferative diabetic retinopathy or proliferative vitreoretinopathy

1 reference

12 December 2020

Angiogenesis in rheumatoid arthritis

1 reference

12 December 2020

Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production

1 reference

12 December 2020

The splice variants of vascular endothelial growth factor (VEGF) and their receptors

1 reference

12 December 2020

Association of VEGF and eNOS gene polymorphisms in type 2 diabetic retinopathy

1 reference

12 December 2020

CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells

1 reference

12 December 2020

A novel mechanism for endothelial progenitor cells homing: The SDF-1/CXCR4-Rac pathway may regulate endothelial progenitor cells homing through cellular polarization

1 reference

12 December 2020

Clinical advances in the development of novel VEGFR2 inhibitors

1 reference

12 December 2020

Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis

1 reference

12 December 2020

Direct identification of a major autophosphorylation site on vascular endothelial growth factor receptor Flt-1 that mediates phosphatidylinositol 3'-kinase binding

1 reference

12 December 2020

Signal transduction by vascular endothelial growth factor receptors

1 reference

12 December 2020

Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure

1 reference

12 December 2020

Treating diabetes by blocking a vascular growth factor

1 reference

12 December 2020

Characterization of the receptors for vascular endothelial growth factor

1 reference

12 December 2020

10.1007/S10545-015-9838-4

Identifiers

DOI

1 reference

PubMed ID

25868665

Dimensions Publication ID

2 September 2017

1039737530

0 references

Microsoft Academic ID

0 references

1 reference