Targeting liver X receptors in cancer therapeutics (Q38382991)

2 September 2017

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title

Targeting liver X receptors in cancer therapeutics (English)

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2 September 2017

Chin-Yo Lin

1

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2 September 2017

Jan-Åke Gustafsson

series ordinal

2

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2 September 2017

language of work or name

English

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publication date

19 March 2015

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2 September 2017

Nature Reviews Cancer

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2 September 2017

15

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2 September 2017

4

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2 September 2017

216-224

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https://scigraph.springernature.com/pub.10.1038/nrc3912

2 September 2017

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cites work

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Antiandrogens in prostate cancer endocrine therapy

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A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily

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OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptor

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LXR, a nuclear receptor that defines a distinct retinoid response pathway

31 March 2020

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A unified nomenclature system for the nuclear receptor superfamily

31 March 2020

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Structure of the retinoid X receptor α-liver X receptor β (RXRα-LXRβ) heterodimer on DNA

31 March 2020

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An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha

31 March 2020

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

31 March 2020

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Plant sterols and stanols: effects on mixed micellar composition and LXR (target gene) activation

31 March 2020

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Identification of 5α, 6α-epoxycholesterol as a novel modulator of liver X receptor activity

31 March 2020

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Unsaturated fatty acids inhibit transcription of the sterol regulatory element-binding protein-1c (SREBP-1c) gene by antagonizing ligand-dependent activation of the LXR.

31 March 2020

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Polyunsaturated fatty acids suppress sterol regulatory element-binding protein 1c promoter activity by inhibition of liver X receptor (LXR) binding to LXR response elements

31 March 2020

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Riccardin C: a natural product that functions as a liver X receptor (LXR)alpha agonist and an LXRbeta antagonist

31 March 2020

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Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha

31 March 2020

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Role of LXRs in control of lipogenesis

31 March 2020

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T0901317 is a dual LXR/FXR agonist

31 March 2020

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T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR

31 March 2020

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Identification of a nonsteroidal liver X receptor agonist through parallel array synthesis of tertiary amines

31 March 2020

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Synthetic LXR ligand inhibits the development of atherosclerosis in mice

31 March 2020

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Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist

31 March 2020

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Gene-selective modulation by a synthetic oxysterol ligand of the liver X receptor

31 March 2020

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Selective liver X receptor modulators (SLiMs): what use in human health?

31 March 2020

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Action mechanisms of Liver X Receptors.

31 March 2020

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Liver X receptor biology and pharmacology: new pathways, challenges and opportunities.

31 March 2020

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Genome-wide profiling of liver X receptor, retinoid X receptor, and peroxisome proliferator-activated receptor α in mouse liver reveals extensive sharing of binding sites

31 March 2020

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Genome-wide analysis of estrogen receptor binding sites

31 March 2020

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Whole-genome cartography of estrogen receptor alpha binding sites

31 March 2020

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Liver X receptor β activation induces pyroptosis of human and murine colon cancer cells

31 March 2020

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Differential SUMOylation of LXRalpha and LXRbeta mediates transrepression of STAT1 inflammatory signaling in IFN-gamma-stimulated brain astrocytes.

31 March 2020

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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha

31 March 2020

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Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue

31 March 2020

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LXRbeta is required for adipocyte growth, glucose homeostasis, and beta cell function

31 March 2020

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Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice

31 March 2020

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Both liver-X receptor (LXR) isoforms control energy expenditure by regulating brown adipose tissue activity

31 March 2020

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Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression

31 March 2020

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Liver X receptor beta (LXRbeta): a link between beta-sitosterol and amyotrophic lateral sclerosis-Parkinson's dementia

31 March 2020

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

31 March 2020

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LXR activation reduces proinflammatory cytokine expression in human CD4-positive lymphocytes

31 March 2020

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LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration.

31 March 2020

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Liver-X-receptor activator prevents homocysteine-induced production of IgG antibodies from murine B lymphocytes via the ROS-NF-kappaB pathway

31 March 2020

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Liver X receptors control IgE expression in B cells.

31 March 2020

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LIVER X RECEPTOR IS A KEY REGULATOR OF CYTOKINE RELEASE IN HUMAN MONOCYTES

31 March 2020

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Liver X receptors as integrators of metabolic and inflammatory signaling

31 March 2020

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LXR-mediated inhibition of CD4+ T helper cells

31 March 2020

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Liver X receptor activation decreases the severity of experimental autoimmune encephalomyelitis.

31 March 2020

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LXR-dependent gene expression is important for macrophage survival and the innate immune response

31 March 2020

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Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis

31 March 2020

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Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses

31 March 2020

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Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.

31 March 2020

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Thematic review series: skin lipids. Peroxisome proliferator-activated receptors and liver X receptors in epidermal biology.

31 March 2020

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Role of PPAR, LXR, and PXR in epidermal homeostasis and inflammation.

31 March 2020

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LXR modulation blocks prostaglandin E2 production and matrix degradation in cartilage and alleviates pain in a rat osteoarthritis model

31 March 2020

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Simultaneous activation of the liver X receptors (LXR and LXR ) drives murine collagen-induced arthritis disease pathology

31 March 2020

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Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

31 March 2020

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The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

31 March 2020

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31 March 2020

LIPID CONTENT OF TUMORS.

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Epoxycholesterols in secretions and tissues of normal, benign, and cancerous human prostate glands

31 March 2020

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Dysregulation of sterol response element-binding proteins and downstream effectors in prostate cancer during progression to androgen independence

31 March 2020

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Antiproliferative effect of liver X receptor agonists on LNCaP human prostate cancer cells

31 March 2020

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Anti-proliferative effect of LXR agonist T0901317 in ovarian carcinoma cells

31 March 2020

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The oxysterol receptor LXR inhibits proliferation of human breast cancer cells

31 March 2020

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Liver X receptors interfere with cytokine-induced proliferation and cell survival in normal and leukemic lymphocytes.

31 March 2020

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Liver × receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism.

31 March 2020

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The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.

31 March 2020

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Liver X receptors inhibit proliferation of human colorectal cancer cells and growth of intestinal tumors in mice

31 March 2020

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Antiproliferative effects and mechanisms of liver X receptor ligands in pancreatic ductal adenocarcinoma cells.

31 March 2020

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Activation of liver X receptors inhibits hedgehog signaling, clonogenic growth, and self-renewal in multiple myeloma

31 March 2020

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Liver X receptor activation induces apoptosis of melanoma cell through caspase pathway

31 March 2020

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Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation

31 March 2020

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Androgenic suppression of ATP-binding cassette transporter A1 expression in LNCaP human prostate cancer cells

31 March 2020

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Liver X Receptor activation downregulates AKT survival signaling in lipid rafts and induces apoptosis of prostate cancer cells.

31 March 2020

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Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity

31 March 2020

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LXR agonist regulates the carcinogenesis of PCa via the SOCS3 pathway

31 March 2020

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Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.

31 March 2020

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An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

31 March 2020

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Convergent multi-miRNA targeting of ApoE drives LRP1/LRP8-dependent melanoma metastasis and angiogenesis.

31 March 2020

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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models

31 March 2020

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A proof-of-principle clinical trial of bexarotene in patients with non-small cell lung cancer

31 March 2020

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Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer

31 March 2020

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Induced differentiation of acute myeloid leukemia cells by activation of retinoid X and liver X receptors

31 March 2020

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The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells

31 March 2020

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Estrogen deprivation and inhibition of breast cancer growth in vivo through activation of the orphan nuclear receptor liver X receptor

31 March 2020

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Tumor-mediated liver X receptor-alpha activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses

31 March 2020

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Identification of interferon-γ as a new molecular target of liver X receptor

31 March 2020

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Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2.

31 March 2020

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Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.

31 March 2020

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Tissue-specific liver X receptor activation promotes macrophage reverse cholesterol transport in vivo

31 March 2020

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Localisation of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor.

31 March 2020

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12 December 2020

Separation of the hormone- and DNA-binding sites of the hepatic glucocorticoid receptor by means of proteolysis

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12 December 2020

Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors

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12 December 2020

LXR agonists and ABCG1-dependent cholesterol efflux in MCF-7 breast cancer cells: relation to proliferation and apoptosis.

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12 December 2020

Androgen deprivation by activating the liver X receptor

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12 December 2020

Macrophage apolipoprotein E and proliferation of MCF-7 breast cancer cells: role of LXR.

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12 December 2020

Identifiers

DOI

10.1038/NRC3912

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Dimensions Publication ID

2 September 2017

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