The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? (Q38374332)

2 September 2017

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title

The Parkinson Disease Mitochondrial Hypothesis: Where Are We at? (English)

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Parkinson disease, mitochondrial

2 September 2017

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1 reference

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

Miquel Vila

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

author name string

Celine Perier

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

publication date

11 March 2015

1 reference

2 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

volume

22

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

issue

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

5 June 2020

page(s)

266-277

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25761946%20AND%20SRC:MED&resulttype=core&format=json

Mitochondrial and nuclear cross talk in cell death: parthanatos

5 June 2020

cites work

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DJ-1 gene deletion reveals that DJ-1 is an atypical peroxiredoxin-like peroxidase

21 January 2018

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High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease

21 January 2018

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Loss of mitochondrial fission depletes axonal mitochondria in midbrain dopamine neurons

21 January 2018

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Chronic systemic pesticide exposure reproduces features of Parkinson's disease

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease

21 January 2018

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α-Synuclein controls mitochondrial calcium homeostasis by enhancing endoplasmic reticulum-mitochondria interactions.

21 January 2018

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'Rejuvenation' protects neurons in mouse models of Parkinson's disease

21 January 2018

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Mitochondrial trafficking to synapses in cultured primary cortical neurons.

21 January 2018

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Inhibition of apoptotic Bax translocation to the mitochondria is a central function of parkin.

21 January 2018

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Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells

21 January 2018

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Sustained expression of PGC-1α in the rat nigrostriatal system selectively impairs dopaminergic function.

21 January 2018

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Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice

21 January 2018

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Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

21 January 2018

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Parkinson's disease: mechanisms and models

21 January 2018

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Mitofusin 2 tethers endoplasmic reticulum to mitochondria

21 January 2018

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Lysosomal impairment in Parkinson's disease

21 January 2018

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Regulation of mitochondrial dehydrogenases by calcium ions

21 January 2018

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Functions and dysfunctions of mitochondrial dynamics

21 January 2018

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Progressive parkinsonism in mice with respiratory-chain-deficient dopamine neurons

21 January 2018

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Mutual exacerbation of peroxisome proliferator-activated receptor γ coactivator 1α deregulation and α-synuclein oligomerization

21 January 2018

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OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion

21 January 2018

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α-Synuclein is localized to mitochondria-associated ER membranes

21 January 2018

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Immunohistochemical studies on complexes I, II, III, and IV of mitochondria in Parkinson's disease.

21 January 2018

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Two-stage association study and meta-analysis of mitochondrial DNA variants in Parkinson disease

21 January 2018

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Apoptotic mechanisms in mutant LRRK2-mediated cell death

21 January 2018

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Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

21 January 2018

1 reference

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Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled.

21 January 2018

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Reduced basal autophagy and impaired mitochondrial dynamics due to loss of Parkinson's disease-associated protein DJ-1

21 January 2018

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

21 January 2018

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

21 January 2018

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Selective mitochondrial autophagy, or mitophagy, as a targeted defense against oxidative stress, mitochondrial dysfunction, and aging

21 January 2018

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The transgenic overexpression of alpha-synuclein and not its related pathology associates with complex I inhibition.

21 January 2018

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Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1, 2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

21 January 2018

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Sensitivity to oxidative stress in DJ-1-deficient dopamine neurons: an ES- derived cell model of primary Parkinsonism

21 January 2018

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Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson's disease

21 January 2018

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The Parkinson disease-related protein DJ-1 counteracts mitochondrial impairment induced by the tumour suppressor protein p53 by enhancing endoplasmic reticulum-mitochondria tethering.

21 January 2018

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Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms

21 January 2018

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Mitochondria and programmed cell death in Parkinson's disease: apoptosis and beyond

21 January 2018

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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease

21 January 2018

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Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage

21 January 2018

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Mitochondrial biology and Parkinson's disease

21 January 2018

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Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease

21 January 2018

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Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1)-dependent ubiquitination of endogenous Parkin attenuates mitophagy: study in human primary fibroblasts and induced pluripotent stem cell-derived neurons

21 January 2018

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Optic atrophy 1 mediates mitochondria remodeling and dopaminergic neurodegeneration linked to complex I deficiency.

21 January 2018

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Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

21 January 2018

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Drp1 inhibition attenuates neurotoxicity and dopamine release deficits in vivo

21 January 2018

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The impact of pathogenic mitochondrial DNA mutations on substantia nigra neurons.

21 January 2018

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Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease

21 January 2018

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Mitochondrial dynamics and neuronal fate in Parkinson's disease.

21 January 2018

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Parkin and PINK1: much more than mitophagy

21 January 2018

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Mitochondrial complex I deficiency in Parkinson's disease

21 January 2018

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α-Synuclein in Parkinson's disease

21 January 2018

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Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators

21 January 2018

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Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels.

21 January 2018

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Apoptosis driven by IP(3)-linked mitochondrial calcium signals

21 January 2018

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The interplay between mitochondrial dynamics and mitophagy

21 January 2018

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MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond

21 January 2018

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Programmed cell death in Parkinson's disease

21 January 2018

1 reference

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Mitophagy: the latest problem for Parkinson's disease

21 January 2018

1 reference

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PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c.

21 January 2018

1 reference

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Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos

21 January 2018

1 reference

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21 January 2018

Mechanisms of mitophagy

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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

21 January 2018

1 reference

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