Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors. (Q38364773)

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16 January 2020

title

Blockade of JAK2-mediated extrinsic survival signals restores sensitivity of CML cells to ABL inhibitors (English)

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16 January 2020

7

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16 January 2020

Jennifer L Snead

3

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16 January 2020

Anna M Eiring

5

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16 January 2020

author name string

E Traer

1

1 reference

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16 January 2020

R MacKenzie

2

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16 January 2020

A Agarwal

4

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16 January 2020

T O'Hare

6

1 reference

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16 January 2020

M W Deininger

8

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16 January 2020

publication date

18 November 2011

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16 January 2020

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volume

26

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16 January 2020

issue

5

1 reference

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16 January 2020

page(s)

1140-1143

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https://scigraph.springernature.com/pub.10.1038/leu.2011.325

16 January 2020

exact match

0 references

cites work

Destabilization of Bcr-Abl/Jak2 Network by a Jak2/Abl Kinase Inhibitor ON044580 Overcomes Drug Resistance in Blast Crisis Chronic Myelogenous Leukemia (CML)

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6 September 2017

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CYT387, a selective JAK1/JAK2 inhibitor: in vitro assessment of kinase selectivity and preclinical studies using cell lines and primary cells from polycythemia vera patients

6 September 2017

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Stat3 contributes to resistance toward BCR-ABL inhibitors in a bone marrow microenvironment model of drug resistance

6 September 2017

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6 September 2017

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TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations

6 September 2017

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Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells

6 September 2017

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

14 September 2017

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Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity

14 September 2017

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Functionally distinct human marrow stromal cell lines immortalized by transduction with the human papilloma virus E6/E7 genes.

27 September 2017

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Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

27 September 2017

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Blocking cytokine signaling along with intense Bcr-Abl kinase inhibition induces apoptosis in primary CML progenitors

23 June 2018

1 reference

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Bcr-Abl efficiently induces a myeloproliferative disease and production of excess interleukin-3 and granulocyte-macrophage colony-stimulating factor in mice: a novel model for chronic myelogenous leukemia

23 June 2018

1 reference

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Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

23 June 2018

1 reference

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Comparison of effects of the tyrosine kinase inhibitors AG957, AG490, and STI571 on BCR-ABL--expressing cells, demonstrating synergy between AG490 and STI571.

31 August 2018

1 reference

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Adaptive secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF) mediates imatinib and nilotinib resistance in BCR/ABL+ progenitors via JAK-2/STAT-5 pathway activation

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FLEU.2011.325

Nilotinib exerts equipotent antiproliferative effects to imatinib and does not induce apoptosis in CD34+ CML cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22094585

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22094585

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/LEU.2011.325

1 reference

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Dimensions Publication ID

16 January 2020

0 references

1 reference

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16 January 2020

1 reference