Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels (Q38361866)

2 September 2017

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels (English)

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2 September 2017

liver X receptor agonist

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nervous system

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author name string

Hiroaki Fukumoto

1

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2 September 2017

Amy Deng

2

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2 September 2017

Michael C Irizarry

3

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2 September 2017

Michael L Fitzgerald

4

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2 September 2017

G William Rebeck

5

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2 September 2017

language of work or name

English

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publication date

15 October 2002

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

277

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2 September 2017

48508-48513

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2 September 2017

50

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Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease

2 September 2017

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Transport of lipids from golgi to plasma membrane is defective in tangier disease patients and Abc1-deficient mice.

21 January 2018

1 reference

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Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor

21 January 2018

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

21 January 2018

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A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport

21 January 2018

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Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages.

21 January 2018

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Apolipoprotein E: cholesterol transport protein with expanding role in cell biology

21 January 2018

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

21 January 2018

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Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

21 January 2018

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Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

21 January 2018

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Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide

21 January 2018

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Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

21 January 2018

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A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease

21 January 2018

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Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease

21 January 2018

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Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, population based study

21 January 2018

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Statins and the risk of dementia

21 January 2018

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Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

21 January 2018

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Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

21 January 2018

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ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space.

21 January 2018

1 reference

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In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain

21 January 2018

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Alpha2-macroglobulin enhances the clearance of endogenous soluble beta-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons.

21 January 2018

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Cellular localization and trafficking of the human ABCA1 transporter

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

21 January 2018

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ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

21 January 2018

1 reference

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Cloning of two novel ABC transporters mapping on human chromosome 9

21 January 2018

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Localization of human ATP-binding cassette transporter 1 (ABC1) in normal and atherosclerotic tissues

21 January 2018

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Dissociation of apolipoprotein and apolipoprotein receptor response to lesion in the rat brain: an in situ hybridization study.

21 January 2018

1 reference

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Regulation of Cholesterol Homeostasis by the Liver X Receptors in the Central Nervous System

21 January 2018

1 reference

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cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain

21 January 2018

1 reference

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Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

21 January 2018

1 reference

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

21 January 2018

1 reference

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Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration

21 January 2018

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Oxysterols: friends, foes, or just fellow passengers?

21 January 2018

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Specific binding of ApoA-I, enhanced cholesterol efflux, and altered plasma membrane morphology in cells expressing ABC1.

21 January 2018

1 reference

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Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

21 January 2018

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Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes.

21 January 2018

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Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease

21 January 2018

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Head injury and the risk of AD in the MIRAGE study

21 January 2018

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Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury.

21 January 2018

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Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer's disease compared to healthy controls

21 January 2018

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24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia

21 January 2018

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Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

21 January 2018

1 reference

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Reduction of plasma 24S-hydroxycholesterol (cerebrosterol) levels using high-dosage simvastatin in patients with hypercholesterolemia: evidence that simvastatin affects cholesterol metabolism in the human brain

21 January 2018

1 reference

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Primary cultures of neuronal and non-neuronal rat brain cells secrete similar proportions of amyloid β peptides ending at Aβ40 and Aβ42

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M209085200

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2 September 2017

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