Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN (Q38343144)

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scientific article published on 25 March 2004

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English	Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN	scientific article published on 25 March 2004

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scholarly article

1 reference

Europe PubMed Central

2 September 2017

Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DN (English)

1 reference

Europe PubMed Central

2 September 2017

Miguel A Martinez

5

1 reference

Europe PubMed Central

2 September 2017

4

object named as

Antonio Mas

1 reference

Europe PubMed Central

2 September 2017

Luis Menéndez-Arias

6

object named as

Luis Menéndez-Arias

1 reference

Europe PubMed Central

2 September 2017

author name string

Tania Matamoros

1

1 reference

Europe PubMed Central

2 September 2017

Sandra Franco

2

1 reference

Europe PubMed Central

2 September 2017

Blanca M Vázquez-Alvarez

3

1 reference

Europe PubMed Central

2 September 2017

language of work or name

0 references

publication date

25 March 2004

1 reference

Europe PubMed Central

2 September 2017

number of pages

9

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based on heuristic

inferred from page(s)

Journal of Biological Chemistry

1 reference

Europe PubMed Central

2 September 2017

279

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Europe PubMed Central

2 September 2017

23

1 reference

Europe PubMed Central

2 September 2017

24569-24577

1 reference

Europe PubMed Central

2 September 2017

Targeting HIV: antiretroviral therapy and development of drug resistance.

1 reference

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The HIV-1 reverse transcription (RT) process as target for RT inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Structural mechanisms of HIV drug resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Molecular mechanisms of HIV-1 resistance to nucleoside reverse transcriptase inhibitors (NRTIs).

1 reference

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21 January 2018

Phenotypic mechanism of HIV-1 resistance to 3'-azido-3'-deoxythymidine (AZT): increased polymerization processivity and enhanced sensitivity to pyrophosphate of the mutant viral reverse transcriptase

1 reference

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21 January 2018

Unblocking of chain-terminated primer by HIV-1 reverse transcriptase through a nucleotide-dependent mechanism

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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acids

1 reference

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21 January 2018

Differential removal of thymidine nucleotide analogues from blocked DNA chains by human immunodeficiency virus reverse transcriptase in the presence of physiological concentrations of 2'-deoxynucleoside triphosphates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Multidrug-resistant HIV-1 reverse transcriptase: involvement of ribonucleotide-dependent phosphorolysis in cross-resistance to nucleoside analogue inhibitors.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

ATP-dependent removal of nucleoside reverse transcriptase inhibitors by human immunodeficiency virus type 1 reverse transcriptase

1 reference

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Probing the molecular mechanisms of AZT drug resistance mediated by HIV-1 reverse transcriptase using a transient kinetic analysis

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Interactions between drug resistance mutations in human immunodeficiency virus type 1 reverse transcriptase

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Phenotypic susceptibilities to tenofovir in a large panel of clinically derived human immunodeficiency virus type 1 isolates.

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Genotypic and phenotypic analyses of HIV-1 in antiretroviral-experienced patients treated with tenofovir DF.

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Broad Nucleoside Reverse‐Transcriptase Inhibitor Cross‐Resistance in Human Immunodeficiency Virus Type 1 Clinical Isolates

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Emergence of human immunodeficiency virus type 1 variants with resistance to multiple dideoxynucleosides in patients receiving therapy with dideoxynucleosides.

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21 January 2018

Genotypic, phenotypic, and modeling studies of a deletion in the beta3-beta4 region of the human immunodeficiency virus type 1 reverse transcriptase gene that is associated with resistance to nucleoside reverse transcriptase inhibitors

1 reference

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21 January 2018

A 6-basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Role of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Biochemical mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to stavudine

1 reference

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21 January 2018

Mispair extension fidelity of human immunodeficiency virus type 1 reverse transcriptases with amino acid substitutions affecting Tyr115.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Deoxynucleoside triphosphate and pyrophosphate binding sites in the catalytically competent ternary complex for the polymerase reaction catalyzed by DNA polymerase I (Klenow fragment).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Substitution of conserved hydrophobic residues in motifs B and C of HIV-1 RT alters the geometry of its catalytic pocket

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Mutational analysis of Phe160 within the "palm" subdomain of human immunodeficiency virus type 1 reverse transcriptase.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Recombinant virus assay: a rapid, phenotypic assay for assessment of drug susceptibility of human immunodeficiency virus type 1 isolates.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Stable rearrangements of the beta3-beta4 hairpin loop of HIV-1 reverse transcriptase in plasma viruses from patients receiving combination therapy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Genotypic and phenotypic resistance patterns of human immunodeficiency virus type 1 variants with insertions or deletions in the reverse transcriptase (RT): multicenter study of patients treated with RT inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Peptide insertions in reverse transcriptase pol gene of human immunodeficiency virus type 1 as a rare cause of persistent antiretroviral therapeutic failure.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Selection by AZT and rapid replacement in the absence of drugs of HIV type 1 resistant to multiple nucleoside analogs

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Relationship between 3′-Azido-3′-Deoxythymidine Resistance and Primer Unblocking Activity in Foscarnet-Resistant Mutants of Human Immunodeficiency Virus Type 1 Reverse Transcriptase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M312658200

21 January 2018

Insertions in the reverse transcriptase increase both drug resistance and viral fitness in a human immunodeficiency virus type 1 isolate harboring the multi-nucleoside reverse transcriptase inhibitor resistance 69 insertion complex mutation

1 reference

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21 January 2018

Molecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations

1 reference

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21 January 2018

Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase

1 reference

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21 January 2018

Structure of a covalently trapped catalytic complex of HIV-1 reverse transcriptase: implications for drug resistance

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Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2.8 A resolution

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Structures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.

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Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase

1 reference

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21 January 2018

3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes

1 reference

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21 January 2018

Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.

1 reference

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21 January 2018

Coupling ribose selection to fidelity of DNA synthesis. The role of Tyr-115 of human immunodeficiency virus type 1 reverse transcriptase.

1 reference

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21 January 2018

Dynamics of dominance of a dipeptide insertion in reverse transcriptase of HIV-1 from patients subjected to prolonged therapy

1 reference

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21 January 2018

Establishment of new transmissible and drug-sensitive human immunodeficiency virus type 1 wild types due to transmission of nucleoside analogue-resistant virus

1 reference

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21 January 2018

Increased ability for selection of zidovudine resistance in a distinct class of wild-type HIV-1 from drug-naive persons

1 reference

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21 January 2018

A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M312658200

1 reference

Europe PubMed Central

2 September 2017

1 reference

Europe PubMed Central

2 September 2017

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