Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis? (Q38341967)

2 September 2017

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title

Anti-inflammatory drugs in epilepsy: does it impact epileptogenesis? (English)

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2 September 2017

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1

Annamaria Vezzani

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PubMed ID

25645535

2 September 2017

language of work or name

English

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publication date

3 February 2015

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Expert Opinion on Drug Safety

2 September 2017

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2 September 2017

14

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2 September 2017

4

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2 September 2017

583-592

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Past and present definitions of epileptogenesis and its biomarkers

2 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Mechanisms of epileptogenesis and potential treatment targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Glia and epilepsy: excitability and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

In vivo imaging of glia activation using 1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The IL-1beta system in epilepsy-associated malformations of cortical development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

(R)-[11C]PK11195 brain uptake as a biomarker of inflammation and antiepileptic drug resistance: evaluation in a rat epilepsy model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Evidence of activated microglia in focal cortical dysplasia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Astrocyte immune responses in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

PET imaging of brain inflammation during early epileptogenesis in a rat model of temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The role of cytokines in the pathophysiology of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The role of inflammation in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Inflammatory pathways of seizure disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Epileptic encephalitis: the role of the innate and adaptive immune system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Brain infiltration of leukocytes contributes to the pathophysiology of temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Disulfide-containing high mobility group box-1 promotes N-methyl-D-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Clinical characteristics, risk factors and pre-surgical evaluation of post-infectious epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Epileptiform activity induces vascular remodeling and zonula occludens 1 downregulation in organotypic hippocampal cultures: role of VEGF signaling pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The dual role of TNF-α and its receptors in seizures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Opposing actions of hippocampus TNFα receptors on limbic seizure susceptibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Complement activation in experimental and human temporal lobe epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Cyclooxygenase-2 in epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Prostaglandin receptor EP2 in the crosshairs of anti-inflammation, anti-cancer, and neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Inflammation and prevention of epileptogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Inflammation induced by LPS enhances epileptogenesis in immature rat and may be partially reversed by IL1RA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Antagonism of peripheral inflammation reduces the severity of status epilepticus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Inflammation and epilepsy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Biomarkers of epileptogenesis: psychiatric comorbidities (?)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Epilepsy and brain inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

A novel, noninvasive, predictive epilepsy biomarker with clinical potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Molecular cascades that mediate the influence of inflammation on epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Neuromodulatory properties of inflammatory cytokines and their impact on neuronal excitability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Blood-brain barrier dysfunction, TGFβ signaling, and astrocyte dysfunction in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Cellular injury and neuroinflammation in children with chronic intractable epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Intravenous immunoglobulin therapy in intractable childhood epilepsy: open-label study and review of the literature

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The ketogenic diet: what has science taught us?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Vagus nerve stimulation: from epilepsy to the cholinergic anti-inflammatory pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Ketogenic Diets: An Update for Child Neurologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Dietary treatment in adults with refractory epilepsy: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The neurobiology of antiepileptic drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Safety of extended treatment with anakinra in patients with rheumatoid arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Candidate drug targets for prevention or modification of epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Pharmacological blockade of IL-1β/IL-1 receptor type 1 axis during epileptogenesis provides neuroprotection in two rat models of temporal lobe epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Neutralization of interleukin-1beta modifies the inflammatory response and improves histological and cognitive outcome following traumatic brain injury in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Aspirin attenuates spontaneous recurrent seizures and inhibits hippocampal neuronal loss, mossy fiber sprouting and aberrant neurogenesis following pilocarpine-induced status epilepticus in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Blood-brain barrier dysfunction, seizures and epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Hitting a moving target: Basic mechanisms of recovery from acquired developmental brain injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

The challenge and promise of anti-epileptic therapy development in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Brain inflammation as a biomarker in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Specific imaging of inflammation with the 18 kDa translocator protein ligand DPA-714 in animal models of epilepsy and stroke

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Synthesis and evaluation of [¹⁸F]fluororasagiline, a novel positron emission tomography (PET) radioligand for monoamine oxidase B (MAO-B).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Molecular magnetic resonance imaging of brain-immune interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Imaging seizure-induced inflammation using an antibody targeted iron oxide contrast agent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

Epigenetic mechanisms in epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14740338.2015.1010508

10.1517/14740338.2015.1010508

21 January 2018

Identifiers

DOI

1 reference

2 September 2017

1 reference

PubMed ID

25645535