The noncoding human genome and the future of personalised medicine (Q38337093)

2 September 2017

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title

The noncoding human genome and the future of personalised medicine (English)

1 reference

2 September 2017

Philip Cowie

1

1 reference

PubMed ID

25634368

2 September 2017

Elizabeth A Hay

series ordinal

2

1 reference

PubMed ID

25634368

2 September 2017

Alasdair MacKenzie

series ordinal

3

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2 September 2017

30 January 2015

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Expert Reviews in Molecular Medicine

2 September 2017

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2 September 2017

17

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2 September 2017

e4

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Simultaneous DNA and RNA isolation from brain punches for epigenetics

2 September 2017

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

The role of maternal care in shaping CNS function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Genes learn from stress: how infantile trauma programs us for depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Dynamic DNA methylation programs persistent adverse effects of early-life stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

The impact of early nutrition on the ageing trajectory

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Oxidative bisulfite sequencing of 5-methylcytosine and 5-hydroxymethylcytosine

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Nanodomain coupling between Ca²⁺ channels and sensors of exocytosis at fast mammalian synapses

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

R-loop formation is a distinctive characteristic of unmethylated human CpG island promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Regulation of chromatin by histone modifications

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Exploring the effects of polymorphisms on cis-regulatory signal transduction response

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

On the immortality of television sets: "function" in the human genome according to the evolution-free gospel of ENCODE

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

An integrated encyclopedia of DNA elements in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Systematic localization of common disease-associated variation in regulatory DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A polymorphism associated with depressive disorders differentially regulates brain derived neurotrophic factor promoter IV activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

The CREB1-BDNF-NTRK2 pathway in depression: multiple gene-cognition-environment interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Differential activity by polymorphic variants of a remote enhancer that supports galanin expression in the hypothalamus and amygdala: implications for obesity, depression and alcoholism

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Genetics, genomics, and their relevance to pathology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A common sex-dependent mutation in a RET enhancer underlies Hirschsprung disease risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Preaxial polydactyly: a model for defective long-range regulation in congenital abnormalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Substance P in stress and anxiety: NK-1 receptor antagonism interacts with key brain areas of the stress circuitry.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Prediction and characterisation of a highly conserved, remote and cAMP responsive enhancer that regulates Msx1 gene expression in cardiac neural crest and outflow tract.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Transcriptional ‘enhancers’ from SV40 and polyoma virus show a cell type preference

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Transcription factories: genome organization and gene regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Functional and topological characteristics of mammalian regulatory domains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Making connections: insulators organize eukaryotic chromosomes into independent cis-regulatory networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A decade of 3C technologies: insights into nuclear organization

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Long-range regulatory synergy is required to allow control of the TAC1 locus by MEK/ERK signalling in sensory neurones

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A remote and highly conserved enhancer supports amygdala specific expression of the gene encoding the anxiogenic neuropeptide substance-P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Disruption of a long-range cis-acting regulator for Shh causes preaxial polydactyly

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Enhancers and silencers: an integrated and simple model for their function

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A new world of Polycombs: unexpected partnerships and emerging functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

ChIP-seq and beyond: new and improved methodologies to detect and characterize protein-DNA interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Genomic location analysis by ChIP-Seq

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Fine tuning of craniofacial morphology by distant-acting enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Modification of enhancer chromatin: what, how, and why?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

An atlas of active enhancers across human cell types and tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Genomic views of distant-acting enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

ChIP-seq accurately predicts tissue-specific activity of enhancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Tissue-specific transcriptional regulation has diverged significantly between human and mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Enhancer identification through comparative genomics

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A highly conserved Wnt-dependent TCF4 binding site within the proximal enhancer of the anti-myogenic Msx1 gene supports expression within Pax3-expressing limb bud muscle precursor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Identification of a Coordinate Regulator of Interleukins 4, 13, and 5 by Cross-Species Sequence Comparisons

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

ZFN, TALEN, and CRISPR/Cas-based methods for genome engineering

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Cannabinoid discrimination and antagonism by CB(1) neutral and inverse agonist antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Two enhancer domains control early aspects of the complex expression pattern of Msx1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Polyomavirus enhancer contains multiple redundant sequence elements that activate both DNA replication and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

A small segment of polyoma virus DNA enhances the expression of a cloned β-globin gene over a distance of 1400 base pairs

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Applied bioinformatics for the identification of regulatory elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Do we need pharmacogenetics to personalize antidepressant therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

The long-range interaction landscape of gene promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Genetics/genomics and drug effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Allele-specific differences in activity of a novel cannabinoid receptor 1 (CNR1) gene intronic enhancer in hypothalamus, dorsal root ganglia, and hippocampus

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Histone tales: echoes from the past, prospects for the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

Metazoan promoters: emerging characteristics and insights into transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Increased serotonin transporter gene (SERT) DNA methylation is associated with bullying victimization and blunted cortisol response to stress in childhood: a longitudinal study of discordant monozygotic twins.

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Point mutations in a distant sonic hedgehog cis-regulator generate a variable regulatory output responsible for preaxial polydactyly

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Epigenetics of early child development

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Uncovering the role of 5-hydroxymethylcytosine in the epigenome

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Epigenetics and depression: return of the repressed

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Maternal separation is associated with DNA methylation and behavioural changes in adult rats

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Epigenetic programming of the HPA axis: early life decides

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

The Janus face of DNA methylation in aging

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Methyl nutrients, DNA methylation, and cardiovascular disease

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Sex differences in brain epigenetics

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

DNA methyltransferases, DNA damage repair, and cancer

1 reference

https://api.crossref.org/works/10.1017%2FERM.2014.23

7 January 2021

Identifiers

DOI

10.1017/ERM.2014.23

1 reference

2 September 2017

1 reference

PubMed ID

25634368