The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1 (Q38334131)

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scientific article published on August 1, 1991

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English	The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1	scientific article published on August 1, 1991

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scholarly article

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Europe PubMed Central

2 September 2017

The immunosuppressant FK-506 specifically inhibits mitogen-induced activation of the interleukin-2 promoter and the isolated enhancer elements NFIL-2A and NF-AT1 (English)

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Europe PubMed Central

2 September 2017

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immunosuppression

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based on heuristic

inferred from title

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10.1128/MCB.11.8.4074-4087.1991

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5 November 2022

author name string

S. S. Banerji

1

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J. N. Parsons

2

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M. J. Tocci

3

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1 August 1991

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http://mcb.asm.org/cgi/content/abstract/11/8/4074

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1712901/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1712901/?tool=EBI

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https://europepmc.org/articles/PMC361217

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https://journals.asm.org/doi/pdf/10.1128/mcb.11.8.4074-4087.1991

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10.1128/MCB.11.8.4074-4087.1991

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Molecular and Cellular Biology

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2 September 2017

11

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8

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Europe PubMed Central

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4074-4087

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Europe PubMed Central

2 September 2017

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells

1 reference

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Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

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Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription

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Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to immediate-early gene products

1 reference

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Promoter region of interleukin-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells

1 reference

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Identification of a putative regulator of early T cell activation genes

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Characterization of antigen receptor response elements within the interleukin-2 enhancer

1 reference

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The NF-kappa B-binding site mediates phorbol ester-inducible transcription in nonlymphoid cells

1 reference

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I kappa B: a specific inhibitor of the NF-kappa B transcription factor

1 reference

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T-cell-specific expression of interleukin 2: evidence for a negative regulatory site

1 reference

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A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor

1 reference

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Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1 reference

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Sequential expression of genes involved in human T lymphocyte growth and differentiation

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A herpesvirus trans-activating protein interacts with transcription factor OTF-1 and other cellular proteins

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T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression

1 reference

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6 September 2017

Contingent genetic regulatory events in T lymphocyte activation

1 reference

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Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1 reference

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6 September 2017

Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation

1 reference

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6 September 2017

Mitogen-induced genes are subject to multiple pathways of regulation in the initial stages of T-cell activation

1 reference

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NF-kappa B activation of the cytomegalovirus enhancer is mediated by a viral transactivator and by T cell stimulation

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The octamer-binding proteins form multi-protein--DNA complexes with the HSV alpha TIF regulatory protein

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6 September 2017

Identification of multiple cis-elements and trans-acting factors involved in the induced expression of human IL-2 gene

1 reference

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6 September 2017

The promoter-regulatory region of the major immediate-early gene of human cytomegalovirus responds to T-lymphocyte stimulation and contains functional cyclic AMP-response elements

1 reference

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Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression

1 reference

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Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1 reference

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6 September 2017

FK 506 for liver, kidney, and pancreas transplantation

1 reference

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A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

1 reference

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6 September 2017

Immunosuppression of canine, monkey, and baboon allografts by FK 506: with special reference to synergism with other drugs and to tolerance induction.

1 reference

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6 September 2017

FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics

1 reference

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6 September 2017

Lymphokine and nonlymphokine mRNA levels in stimulated human T cells. Kinetics, mitogen requirements, and effects of cyclosporin A

1 reference

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Octamer transcription factors and the cell type-specificity of immunoglobulin gene expression

1 reference

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6 September 2017

NF-kappa B: a family of inducible and differentially expressed enhancer-binding proteins in human T cells

1 reference

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6 September 2017

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1 reference

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Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner.

1 reference

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Phytohemagglutinin-induced activity of cyclic AMP (cAMP) response elements from cytomegalovirus is reduced by cyclosporine and synergistically enhanced by cAMP

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Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin

1 reference

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Variation in enzymatic transient gene expression assays

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Involvement of a common transcription factor in the regulated expression of IL-2 and IL-2 receptor genes

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1 reference

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1 reference

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1 reference

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Two regions within the human IL-2 gene promoter are important for inducible IL-2 expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclosporin A inhibits late steps of T lymphocyte activation after transmembrane signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

12 December 2020

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Cooperativity and hierarchical levels of functional organization in the SV40 enhancer

1 reference

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Effects of cyclosporine A on T lymphocytes and accessory cells from human blood

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Immunosuppressive effects of cyclosporin A on cloned T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/1712901

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A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes

1 reference

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T lymphocyte activation through the C28 pathway is insensitive to inhibition by the immunosuppressive drug FK-506

1 reference

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The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes

1 reference

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Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation

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FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro

1 reference

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Cyclosporin A-mediated inhibition of mitogen-induced gene transcription is specific for the mitogenic stimulus and cell type

1 reference

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Induction of interleukin-2 receptor-alpha gene expression is regulated by post-translational activation of kappa B specific DNA binding proteins

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Identifiers

10.1128/MCB.11.8.4074

1 reference

Europe PubMed Central

2 September 2017

10.1128/MCB.11.8.4074-4087.1991

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=1712901

5 November 2022

1 reference

Europe PubMed Central

2 September 2017

1 reference

Europe PubMed Central

2 September 2017

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