FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells. (Q38333689)

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English	FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells.	scientific article

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6 February 2020

FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells (English)

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6 February 2020

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6 February 2020

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6 February 2020

Javier Garcia-castro

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6 February 2020

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Ruth Rubio

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6 February 2020

Ivan Gutierrez-Aranda

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6 February 2020

Carolina Elosua

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1 February 2011

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6 February 2020

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6 February 2020

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6 February 2020

Mesenchymal stem cells and their use as cell replacement therapy and disease modelling tool.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Expression of the FUS-CHOP fusion protein in primary mesenchymal progenitor cells gives rise to a model of myxoid liposarcoma.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Identification of cancer stem cells in Ewing's sarcoma

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Sarcomas and other malignancies of soft tissue, retroperitoneum, peritoneum, pleura, heart, mediastinum, and spleen

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Transcriptional activation by TAL1 and FUS-CHOP proteins expressed in acute malignancies as a result of chromosomal abnormalities.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

The chimeric FUS/TLS-CHOP fusion protein specifically induces liposarcomas in transgenic mice.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Metastatic osteosarcoma induced by inactivation of Rb and p53 in the osteoblast lineage

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Bone marrow mesenchymal stem cells from infants with MLL-AF4+ acute leukemia harbor and express the MLL-AF4 fusion gene

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

A versatile tool for conditional gene expression and knockdown

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Thymidine selectively enhances growth suppressive effects of camptothecin/irinotecan in MSI+ cells and tumors containing a mutation of MRE11.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Conventional and molecular cytogenetic diagnostic methods in stem cell research: a concise review.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Human ESCs predisposition to karyotypic instability: Is a matter of culture adaptation or differential vulnerability among hESC lines due to inherent properties?

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-beta and IGF-II.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Apoptosis induced by replication inhibitors in Chk1-depleted cells is dependent upon the helicase cofactor Cdc45.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Embryonic stem cell-specific miR302-367 cluster: human gene structure and functional characterization of its core promoter

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Transcriptional control of adipocyte formation

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Adipogenic differentiation of human adult stem cells from bone marrow stroma (MSCs).

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

FUS-DDIT3 prevents the development of adipocytic precursors in liposarcoma by repressing PPARgamma and C/EBPalpha and activating eIF4E.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

The endothelin axis in cancer: the promise and the challenges of molecularly targeted therapy.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

IFATS collection: Stem cell antigen-1-positive ear mesenchymal stem cells display enhanced adipogenic potential

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Retinoid metabolism and nuclear receptor responses: New insights into coordinated regulation of the PPAR-RXR complex

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Prolactin enhances CCAAT enhancer-binding protein-beta (C/EBP beta) and peroxisome proliferator-activated receptor gamma (PPAR gamma) messenger RNA expression and stimulates adipogenic conversion of NIH-3T3 cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Effect of ceramide on mesenchymal stem cell differentiation toward adipocytes

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Gene expression profiling of human sarcomas: insights into sarcoma biology

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

The myxoid liposarcoma specific TLS-CHOP fusion protein localizes to nuclear structures distinct from PML nuclear bodies.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Loss of p16 pathways stabilizes EWS/FLI1 expression and complements EWS/FLI1 mediated transformation.

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Murine but not human mesenchymal stem cells generate osteosarcoma-like lesions in the lung

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Sarcoma derived from cultured mesenchymal stem cells

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Regulation of the C/EBP-related gene gadd153 by glucose deprivation

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Identification of novel stress-induced genes downstream of chop

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Adipocyte differentiation from the inside out

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

A potential role for Dkk-1 in the pathogenesis of osteosarcoma predicts novel diagnostic and treatment strategies

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow

1 reference

https://api.crossref.org/works/10.1002%2FSTEM.571

21 January 2018

Phosphoinositide signalling in cancer: beyond PI3K and PTEN.

1 reference

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21 January 2018

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