The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor (Q38328680)

2 September 2017

The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor (English)

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2 September 2017

Monzy Thomas

1

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2 September 2017

Zhigang Yu

2

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2 September 2017

Nahid Dadgar

3

1 reference

2 September 2017

Sooryanarayana Varambally

4

1 reference

2 September 2017

Jianjun Yu

5

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2 September 2017

Arul M Chinnaiyan

6

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2 September 2017

Andrew P Lieberman

7

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2 September 2017

language of work or name

English

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publication date

30 March 2005

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Journal of Biological Chemistry

2 September 2017

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2 September 2017

280

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2 September 2017

22

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2 September 2017

21264-21271

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Glutamine repeats and neurodegeneration

2 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Triplet repeat expansion in neuromuscular disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Androgen receptor gene mutations in X-linked spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Altered transcriptional regulation in cells expressing the expanded polyglutamine androgen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Beyond the Qs in the polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

CREB-binding protein sequestration by expanded polyglutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Neuropathogenic forms of huntingtin and androgen receptor inhibit fast axonal transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Androgen receptor acetylation site mutations cause trafficking defects, misfolding, and aggregation similar to expanded glutamine tracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Castration restores function and neurofilament alterations of aged symptomatic males in a transgenic mouse model of spinal and bulbar muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Testosterone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

A mouse model of spinal and bulbar muscular atrophy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Impairment of the ubiquitin-proteasome system by protein aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Over-expression of inducible HSP70 chaperone suppresses neuropathology and improves motor function in SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Cytosol-endoplasmic reticulum interplay by Sec61alpha translocon in polyglutamine-mediated neurotoxicity in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Organelle-specific initiation of cell death pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Significance analysis of microarrays applied to the ionizing radiation response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Cluster analysis and display of genome-wide expression patterns

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Cleavage, aggregation and toxicity of the expanded androgen receptor in spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Histone deacetylase inhibitors reduce polyglutamine toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

'Unfolding' pathways in neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

Mutants of neuroserpin that cause dementia accumulate as polymers within the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M500144200

21 January 2018

Identifiers

DOI

10.1074/JBC.M500144200

1 reference

release_xz53fcd5anhw7lbfcf5qjdue5y

2 September 2017

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/xz53fcd5anhw7lbfcf5qjdue5y

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference