Novel investigational drugs targeting IL-6 signaling for the treatment of depression (Q38317241)

2 September 2017

1 reference

title

Novel investigational drugs targeting IL-6 signaling for the treatment of depression (English)

1 reference

2 September 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

Sidney H. Kennedy

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

2

Roger S McIntyre

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

author name string

Trehani M Fonseka

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

language of work or name

English

0 references

publication date

14 January 2015

1 reference

Expert Opinion on Investigational Drugs

2 September 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

volume

24

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

31 May 2020

page(s)

459-475

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25585966%20AND%20SRC:MED&resulttype=core&format=json

Global variation in the prevalence and incidence of major depressive disorder: a systematic review of the epidemiological literature.

31 May 2020

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A prospective evaluation of the directionality of the depression-inflammation relationship

21 January 2018

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21 January 2018

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21 January 2018

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Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity.

21 January 2018

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21 January 2018

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Proinflammatory and "resiliency" proteins in the CSF of patients with major depression.

21 January 2018

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Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder

21 January 2018

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Cytokine levels in the blood may distinguish suicide attempters from depressed patients.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Inflammatory biomarkers in depression: an opportunity for novel therapeutic interventions.

21 January 2018

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21 January 2018

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The cyclooxygenase-2 inhibitor celecoxib has therapeutic effects in major depression: results of a double-blind, randomized, placebo controlled, add-on pilot study to reboxetine

21 January 2018

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21 January 2018

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A randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers

21 January 2018

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Crohn's disease, fatigue, and infliximab: is there a role for cytokines in the pathogenesis of fatigue?

21 January 2018

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Patient-reported outcomes and health-care resource utilization in patients with psoriasis treated with etanercept: continuous versus interrupted treatment.

21 January 2018

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Minocycline produced antidepressant-like effects on the learned helplessness rats with alterations in levels of monoamine in the amygdala and no changes in BDNF levels in the hippocampus at baseline.

21 January 2018

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Minocycline as adjunctive therapy for patients with unipolar psychotic depression: an open-label study

21 January 2018

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Efficacy of estradiol for the treatment of depressive disorders in perimenopausal women: a double-blind, randomized, placebo-controlled trial

21 January 2018

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Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats

21 January 2018

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Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB.

21 January 2018

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Role of omega-3 fatty acids in the treatment of depressive disorders: a comprehensive meta-analysis of randomized clinical trials

21 January 2018

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Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome.

21 January 2018

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A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn's disease.

21 January 2018

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Anti-interleukin-6 receptor antibody, tocilizumab, for the treatment of autoimmune diseases.

21 January 2018

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Therapeutic targeting of the interleukin-6 receptor.

21 January 2018

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Responsiveness of the EuroQol EQ-5D and Hospital Anxiety and Depression Scale (HADS) in rheumatoid arthritis patients receiving tocilizumab.

21 January 2018

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Sarilumab, a fully human monoclonal antibody against IL-6Rα in patients with rheumatoid arthritis and an inadequate response to methotrexate: efficacy and safety results from the randomised SARIL-RA-MOBILITY Part A trial

21 January 2018

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Targeting interleukin-6 in inflammatory autoimmune diseases and cancers

21 January 2018

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Pharmacokinetics, pharmacodynamics and safety of a human anti-IL-6 monoclonal antibody (sirukumab) in healthy subjects in a first-in-human study

21 January 2018

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Sirukumab, a human anti-interleukin-6 monoclonal antibody: a randomised, 2-part (proof-of-concept and dose-finding), phase II study in patients with active rheumatoid arthritis despite methotrexate therapy

21 January 2018

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Siltuximab, a novel anti-interleukin-6 monoclonal antibody, for Castleman's disease

21 January 2018

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Siltuximab for multicentric Castleman's disease: a randomised, double-blind, placebo-controlled trial

21 January 2018

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21 January 2018

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Risk of adverse events including serious infections in rheumatoid arthritis patients treated with tocilizumab: a systematic literature review and meta-analysis of randomized controlled trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Soluble gp130 is the natural inhibitor of soluble interleukin-6 receptor transsignaling responses

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Interleukin-6 and its receptor: from bench to bedside

21 January 2018

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The IL-6/sIL-6R complex as a novel target for therapeutic approaches

21 January 2018

1 reference

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Inhibition of classic signaling is a novel function of soluble glycoprotein 130 (sgp130), which is controlled by the ratio of interleukin 6 and soluble interleukin 6 receptor

21 January 2018

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Structure-guided optimization of the interleukin-6 trans-signaling antagonist sgp130.

21 January 2018

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Trajectories of depression severity in clinical trials of duloxetine: insights into antidepressant and placebo responses

21 January 2018

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Assessing the 'true' effect of active antidepressant therapy v. placebo in major depressive disorder: use of a mixture model

21 January 2018

1 reference

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Research domain criteria (RDoC): toward a new classification framework for research on mental disorders

21 January 2018

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A vision for drug discovery and development: novel targets and multilateral partnerships

21 January 2018

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Plasma levels of brain-derived neurotrophic factor and interleukin-6 in patients with dysthymic disorder: comparison with age- and sex-matched major depressed patients and healthy controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Depression, cytokines and experimental pain: evidence for sex-related association patterns.

21 January 2018

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Cytokines and serotonin transporter in patients with major depression.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Dysregulated relationship of inflammation and oxidative stress in major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

A preliminary study of cytokines in suicidal and nonsuicidal adolescents with major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Interleukin-6 genetic polymorphism and Chinese major depression

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Role of cytokines in atypical depression.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Association between serum brain-derived neurotrophic factor and plasma interleukin-6 in major depressive disorder with melancholic features.

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Increased inflammation and lower platelet 5-HT in depression with metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

IL-1β, IL-6, IL-8, IL-10, IFN-γ, TNF-α and its relationship with lipid parameters in patients with major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Effects of zinc supplementation on efficacy of antidepressant therapy, inflammatory cytokines, and brain-derived neurotrophic factor in patients with major depression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Effects of eicosapentaenoic acid and fluoxetine on plasma cortisol, serum interleukin-1beta and interleukin-6 concentrations in patients with major depressive disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Inflammatory changes upon a single maximal exercise test in depressed patients and healthy controls.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

IL-6 levels decrease with SSRI treatment in patients with major depression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Electroconvulsive therapy has acute immunological and neuroendocrine effects in patients with major depressive disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Trans-Signaling Is a Dominant Mechanism for the Pathogenic Actions of Interleukin-6 in the Brain

21 January 2018

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https://api.crossref.org/works/10.1517%2F13543784.2014.998334

Kynurenine pathway in major depression: Evidence of impaired neuroprotection

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.998334