An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment (Q38296791)

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scientific article published on 31 October 2007

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English	An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment	scientific article published on 31 October 2007

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scholarly article

1 reference

Europe PubMed Central

1 September 2017

An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment (English)

1 reference

Europe PubMed Central

1 September 2017

phosphorylation

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based on heuristic

inferred from title

object named as

Wen Zhou

8

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object named as

Wei-Guo Zhu

12

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author name string

Haiying Wang

1

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Europe PubMed Central

1 September 2017

Ying Zhao

2

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Europe PubMed Central

1 September 2017

Lian Li

3

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Europe PubMed Central

1 September 2017

Michael A McNutt

4

1 reference

Europe PubMed Central

1 September 2017

Lipeng Wu

5

1 reference

Europe PubMed Central

1 September 2017

Shaoli Lu

6

1 reference

Europe PubMed Central

1 September 2017

Yu Yu

7

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Europe PubMed Central

1 September 2017

Jingnan Feng

9

1 reference

Europe PubMed Central

1 September 2017

Guolin Chai

10

1 reference

Europe PubMed Central

1 September 2017

Yang Yang

11

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Europe PubMed Central

1 September 2017

language of work or name

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publication date

31 October 2007

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Europe PubMed Central

1 September 2017

Journal of Biological Chemistry

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Europe PubMed Central

1 September 2017

283

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Europe PubMed Central

1 September 2017

2564-2574

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Europe PubMed Central

1 September 2017

5

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Europe PubMed Central

1 September 2017

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Post-translational modification of p53 in tumorigenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

The ubiquitin ligase COP1 is a critical negative regulator of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

WAF1, a potential mediator of p53 tumor suppression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Live or let die: the cell's response to p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

DNA damage induces phosphorylation of the amino terminus of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Cell cycle checkpoint signaling through the ATM and ATR kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

p300/CBP-mediated p53 acetylation is commonly induced by p53-activating agents and inhibited by MDM2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

An essential role of human Ada3 in p53 acetylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Acetylation of p53 at lysine 373/382 by the histone deacetylase inhibitor depsipeptide induces expression of p21(Waf1/Cip1).

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Acetylation of p53 inhibits its ubiquitination by Mdm2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Histone deacetylase inhibitors differentially stabilize acetylated p53 and induce cell cycle arrest or apoptosis in prostate cancer cells.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Regulation of p53 activity by its interaction with homeodomain-interacting protein kinase-2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Inhibition of p53-dependent transcription by BOX-I phospho-peptide mimetics that bind to p300.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

5-aza-2'-deoxycytidine activates the p53/p21Waf1/Cip1 pathway to inhibit cell proliferation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Regulation of ATR substrate selection by Rad17-dependent loading of Rad9 complexes onto chromatin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Involvement of the ATR- and ATM-dependent checkpoint responses in cell cycle arrest evoked by pierisin-1.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Nuclear retention of ATM at sites of DNA double strand breaks

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

The ATR pathway: fine-tuning the fork

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: implications for methylation-associated cellular processes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Ionizing radiation activates the ATM kinase throughout the cell cycle

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Requirement for Atr in phosphorylation of Chk1 and cell cycle regulation in response to DNA replication blocks and UV-damaged DNA in Xenopus egg extracts

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

ATR and ATRIP: partners in checkpoint signaling

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Small peptides activate the latent sequence-specific DNA binding function of p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

p53 linear diffusion along DNA requires its C terminus

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Nerve growth factor receptor signaling induces histone acetyltransferase domain-dependent nuclear translocation of p300/CREB-binding protein-associated factor and hGCN5 acetyltransferases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Acetylation of mouse p53 at lysine 317 negatively regulates p53 apoptotic activities after DNA damage

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Neddylating the guardian; Mdm2 catalyzed conjugation of Nedd8 to p53.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702454200

21 January 2018

Identifiers

10.1074/JBC.M702454200

1 reference

Europe PubMed Central

1 September 2017

1 reference

Europe PubMed Central

1 September 2017

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