Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin (Q38296779)

1 September 2017

Novel roles in human MD-2 of phenylalanines 121 and 126 and tyrosine 131 in activation of Toll-like receptor 4 by endotoxin (English)

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1 September 2017

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5

Theresa L Gioannini

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1 September 2017

1

Athmane Teghanemt

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1 September 2017

3

Polonca Prohinar

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1 September 2017

6

Jerrold P Weiss

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1 September 2017

Fabio Re

2

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PubMed ID

17977838

1 September 2017

Richard Widstrom

series ordinal

4

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PubMed ID

17977838

1 September 2017

language of work or name

English

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publication date

30 October 2007

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Journal of Biological Chemistry

1 September 2017

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1 September 2017

283

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1 September 2017

3

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1 September 2017

1257-1266

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Innate immune responses to microbial poisons: discovery and function of the Toll-like receptors

1 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705994200

Recognition of gram-negative bacteria and endotoxin by the innate immune system

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705994200

Endotoxin-binding proteins modulate the susceptibility of bacterial endotoxin to deacylation by acyloxyacyl hydrolase

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M705994200

Biochemical and functional characterization of membrane blebs purified from Neisseria meningitidis serogroup B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Isolation of an endotoxin-MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Structural model of MD-2 and functional role of its basic amino acid clusters involved in cellular lipopolysaccharide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Identification of mouse MD-2 residues important for forming the cell surface TLR4-MD-2 complex recognized by anti-TLR4-MD-2 antibodies, and for conferring LPS and taxol responsiveness on mouse TLR4 by alanine-scanning mutagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Structural regions of MD-2 that determine the agonist-antagonist activity of lipid IVa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

The functional and structural properties of MD-2 required for lipopolysaccharide binding are absent in MD-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Mutational analysis of membrane and soluble forms of human MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Interaction of soluble form of recombinant extracellular TLR4 domain with MD-2 enables lipopolysaccharide binding and attenuates TLR4-mediated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

A complex of soluble MD-2 and lipopolysaccharide serves as an activating ligand for Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

MD-2 binds to bacterial lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Pharmacological inhibition of endotoxin responses is achieved by targeting the TLR4 coreceptor, MD-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Plasma CD14 decreases monocyte responses to LPS by transferring cell-bound LPS to plasma lipoproteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Regulation of interactions of Gram-negative bacterial endotoxins with mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Specific high affinity interactions of monomeric endotoxin.protein complexes with Toll-like receptor 4 ectodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Endotoxin responsiveness of human airway epithelia is limited by low expression of MD-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Molecular basis of reduced potency of underacylated endotoxins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Construction of acetate auxotrophs of Neisseria meningitidis to study host-meningococcal endotoxin interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

An essential role for albumin in the interaction of endotoxin with lipopolysaccharide-binding protein and sCD14 and resultant cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Regulation of interactions of endotoxin with host cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

MD-2: the Toll 'gatekeeper' in endotoxin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Crystal structures of human MD-2 and its complex with antiendotoxic lipid IVa

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Human Toll-like receptor 4 recognizes host-specific LPS modifications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Involvement of TLR4/MD-2 complex in species-specific lipopolysaccharide-mimetic signal transduction by Taxol

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

CD14 is required for MyD88-independent LPS signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

The role of disulfide bonds in the assembly and function of MD-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M705994200

21 January 2018

Identifiers

DOI

10.1074/JBC.M705994200

1 reference

1 September 2017

1 reference

PubMed ID

17977838