Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety (Q38292149)

1 September 2017

1 reference

title

Novel metabotropic glutamate receptor 4 and glutamate receptor 8 therapeutics for the treatment of anxiety (English)

1 reference

1 September 2017

Jacob Raber

1

1 reference

PubMed ID

25518990

1 September 2017

Robert M Duvoisin

series ordinal

2

1 reference

PubMed ID

25518990

1 September 2017

language of work or name

English

0 references

publication date

17 December 2014

1 reference

Expert Opinion on Investigational Drugs

1 September 2017

1 reference

1 September 2017

24

1 reference

1 September 2017

4

1 reference

1 September 2017

519-528

1 reference

The metabotropic glutamate receptors: structure and functions

1 September 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Metabotropic glutamate receptors: a review on prospectives and therapeutic aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Novel treatment approaches for refractory anxiety disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

LY354740, an mGlu2/3 receptor agonist as a novel approach to treat anxiety/stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Increased anxiety-related behavior in mice deficient for metabotropic glutamate 8 (mGlu8) receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Increased measures of anxiety and weight gain in mice lacking the group III metabotropic glutamate receptor mGluR8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Opposing roles of mGluR8 in measures of anxiety involving non-social and social challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Role of mGluR4 in acquisition of fear learning and memory

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Measures of anxiety, sensorimotor function, and memory in male and female mGluR4⁻/⁻ mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Acute pharmacological modulation of mGluR8 reduces measures of anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Characterization of the novel positive allosteric modulator of the metabotropic glutamate receptor 4 ADX88178 in rodent models of neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Group III metabotropic glutamate receptors: pharmacology, physiology and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Autistic-like syndrome in mu opioid receptor null mice is relieved by facilitated mGluR4 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

mGluR4-positive allosteric modulation as potential treatment for Parkinson's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Positive associations of polymorphisms in the metabotropic glutamate receptor type 8 gene (GRM8) with schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Distribution and synaptic localisation of the metabotropic glutamate receptor 4 (mGluR4) in the rodent CNS

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

The effect of mGlu8 deficiency in animal models of psychiatric diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Sex-dependent cognitive phenotype of mice lacking mGluR8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Fear-potentiated startle conditioning in humans: explicit and contextual cue conditioning following paired versus unpaired training.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

The relevance of recent developments in classical conditioning to understanding the etiology and maintenance of anxiety disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Extinction learning in humans: role of the amygdala and vmPFC

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Optical activation of lateral amygdala pyramidal cells instructs associative fear learning

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Contribution of ventrolateral prefrontal cortex to the acquisition and extinction of conditioned fear in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Prefrontal mechanisms in extinction of conditioned fear.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Improved spatial learning is associated with increased hippocampal but not prefrontal long-term potentiation in mGluR4 knockout mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Related functions of mGlu4 and mGlu8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Activation of group II metabotropic glutamate receptors induces depotentiation in amygdala slices and reduces fear-potentiated startle in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Activation of group II metabotropic glutamate receptors results in long-term potentiation following preconditioning stimulation in the dentate gyrus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Group II and III metabotropic glutamate receptors suppress excitatory synaptic transmission in the dorsolateral bed nucleus of the stria terminalis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Distinct properties of presynaptic group II and III metabotropic glutamate receptor-mediated inhibition of perforant pathway-CA1 EPSCs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Opposing efficacy of group III mGlu receptor activators, LSP1-2111 and AMN082, in animal models of positive symptoms of schizophrenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Anxiolytic-like effects of PHCCC, an allosteric modulator of mGlu4 receptors, in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Group III mGlu receptor agonists produce anxiolytic- and antidepressant-like effects after central administration in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Metabotropic glutamate receptor 4 novel agonist LSP1-2111 with anxiolytic, but not antidepressant-like activity, mediated by serotonergic and GABAergic systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Systemic administration of the potent mGlu8 receptor agonist (S)-3,4-DCPG induces c-Fos in stress-related brain regions in wild-type, but not mGlu8 receptor knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Amygdala circuitry mediating reversible and bidirectional control of anxiety

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Context modulation of memory for fear extinction in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Revealing context-specific conditioned fear memories with full immersion virtual reality

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

The effects of midazolam and flumazenil on psychomotor function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Decreased benzodiazepine receptor binding in panic disorder measured by IOMAZENIL-SPECT. A preliminary report.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Reduced benzodiazepine sensitivity in patients with panic disorder: comparison with patients with obsessive-compulsive disorder and normal subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Benzodiazepine receptor sensitivity in panic disorder.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Decreased brain GABA(A)-benzodiazepine receptor binding in panic disorder: preliminary results from a quantitative PET study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Decreased benzodiazepine receptor binding in prefrontal cortex in combat-related posttraumatic stress disorder

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Deficiency of the 65 kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

WGCNA: an R package for weighted correlation network analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.2014.986264

10.1517/13543784.2014.986264

21 January 2018

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

25518990