Physical interaction with human tumor-derived p53 mutants inhibits p63 activities. (Q38291171)

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8 December 2019

title

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities (English)

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8 December 2019

2

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8 December 2019

Antonio Costanzo

3

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8 December 2019

Maria Giulia Rizzo

4

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8 December 2019

Massimo Levrero

8

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8 December 2019

author name string

Sabrina Strano

1

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8 December 2019

Olimpia Monti

5

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8 December 2019

Alessia Baccarini

6

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8 December 2019

Giannino Del Sal

7

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8 December 2019

Ada Sacchi

9

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8 December 2019

Moshe Oren

10

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8 December 2019

Giovanni Blandino

11

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8 December 2019

language of work or name

English

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publication date

13 March 2002

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Journal of Biological Chemistry

8 December 2019

published in

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8 December 2019

volume

277

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8 December 2019

page(s)

18817-18826

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8 December 2019

issue

21

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Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects

8 December 2019

cites work

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p53, the cellular gatekeeper for growth and division

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High level expression of deltaN-p63: a mechanism for the inactivation of p53 in undifferentiated nasopharyngeal carcinoma (NPC)?

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p53 from complexity to simplicity: mutant p53 stabilization, gain-of-function, and dominant-negative effect

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From p63 to p53 across p73.

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Gain of function mutations in p53.

21 January 2018

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Activation of the insulin-like growth factor II transcription by aflatoxin B1 induced p53 mutant 249 is caused by activation of transcription complexes; implications for a gain-of-function during the formation of hepatocellular carcinoma

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Mutant p53 protein expression interferes with p53-independent apoptotic pathways.

21 January 2018

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A gain of function p53 mutant promotes both genomic instability and cell survival in a novel p53-null mammary epithelial cell model

21 January 2018

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A role of cyclin G in the process of apoptosis

21 January 2018

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An oncogenic form of p53 confers a dominant, gain-of-function phenotype that disrupts spindle checkpoint control

21 January 2018

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Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers

21 January 2018

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Lonely no more: p53 finds its kin in a tumor suppressor haven

21 January 2018

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p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

21 January 2018

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Two new p73 splice variants, gamma and delta, with different transcriptional activity.

21 January 2018

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Cloning and functional analysis of human p51, which structurally and functionally resembles p53

21 January 2018

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A novel protein with strong homology to the tumor suppressor p53.

21 January 2018

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A new human p53 homologue

21 January 2018

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P63 and P73: P53 mimics, menaces and more

21 January 2018

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p73 is a simian [correction of human] p53-related protein that can induce apoptosis

21 January 2018

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Induction of the growth inhibitor IGF-binding protein 3 by p53

21 January 2018

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A common polymorphism acts as an intragenic modifier of mutant p53 behaviour

21 January 2018

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Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

21 January 2018

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Physical interaction with Yes-associated protein enhances p73 transcriptional activity

21 January 2018

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p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumours

21 January 2018

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p63 is a p53 homologue required for limb and epidermal morphogenesis

21 January 2018

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p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

21 January 2018

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Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

21 January 2018

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A subset of tumor-derived mutant forms of p53 down-regulate p63 and p73 through a direct interaction with the p53 core domain

21 January 2018

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The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent

21 January 2018

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14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

21 January 2018

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

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p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

21 January 2018

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

21 January 2018

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The emerging p53 gene family

21 January 2018

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Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma

21 January 2018

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Frequent gain of the p40/p51/p63 gene locus in primary head and neck squamous cell carcinoma.

21 January 2018

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Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis

21 January 2018

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The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

21 January 2018

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p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

21 January 2018

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DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

21 January 2018

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A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator

21 January 2018

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Activation of c-myc gene expression by tumor-derived p53 mutants requires a discrete C-terminal domain

21 January 2018

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Integrity of the N-terminal transcription domain of p53 is required for mutant p53 interference with drug-induced apoptosis

21 January 2018

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21 January 2018

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Physical and Functional Interaction between p53 Mutants and Different Isoforms of p73

21 January 2018

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Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M201405200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11893750%20AND%20SRC:MED&resulttype=core&format=json

8 December 2019

1 reference