Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential. (Q38285042)

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24 February 2020

review article

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title

Valproic acid-mediated neuroprotection and neurogenesis after spinal cord injury: from mechanism to clinical potential (English)

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author name string

Tianci Chu

1

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Hengxing Zhou

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Lu Lu

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Xiaohong Kong

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Bin Pan

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Shiqing Feng

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publication date

8 December 2014

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24 February 2020

published in

Regenerative Medicine

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volume

10

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page(s)

193-209

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issue

2

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Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward?

24 February 2020

cites work

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Pathophysiology and pharmacologic treatment of acute spinal cord injury

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Therapeutic interventions after spinal cord injury.

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Adult neurogenesis in the mammalian central nervous system

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Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder

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Valproic acid: a new candidate of therapeutic application for the acute central nervous system injuries

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Neurons derived from transplanted neural stem cells restore disrupted neuronal circuitry in a mouse model of spinal cord injury.

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Valproic acid improves locomotion in vivo after SCI and axonal growth of neurons in vitro

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Valproic acid improves outcome after rodent spinal cord injury: potential roles of histone deacetylase inhibition

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Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury

21 January 2018

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Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells

21 January 2018

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The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells

21 January 2018

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Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes.

21 January 2018

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Mood stabilizer valproate promotes ERK pathway-dependent cortical neuronal growth and neurogenesis.

21 January 2018

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Molecular and therapeutic potential and toxicity of valproic acid

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Distribution of valproate across the interface between blood and cerebrospinal fluid

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Sodium valproate: an old drug with new roles

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Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon

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Review of current evidence for apoptosis after spinal cord injury.

21 January 2018

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Multiple roles of HDAC inhibition in neurodegenerative conditions.

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Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury.

21 January 2018

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The neuroprotective effect of treatment of valproic Acid in acute spinal cord injury

21 January 2018

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Valproic acid attenuates blood-spinal cord barrier disruption by inhibiting matrix metalloprotease-9 activity and improves functional recovery after spinal cord injury

21 January 2018

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Valproic acid reduces autophagy and promotes functional recovery after spinal cord injury in rats

21 January 2018

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Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia

21 January 2018

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Valproic Acid increases expression of neuronal stem/progenitor cell in spinal cord injury

21 January 2018

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Valproic acid inhibits neural progenitor cell death by activation of NF-κB signaling pathway and up-regulation of Bcl-XL.

21 January 2018

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Induction of autophagy and autophagic cell death in damaged neural tissue after acute spinal cord injury in mice.

21 January 2018

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The role of autophagy in spinal cord injury

21 January 2018

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Systemic bisperoxovanadium activates Akt/mTOR, reduces autophagy, and enhances recovery following cervical spinal cord injury

21 January 2018

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Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

21 January 2018

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Spinal cord injury induces early and persistent lesional P2X4 receptor expression.

21 January 2018

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Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity

21 January 2018

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Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia.

21 January 2018

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Histone deacetylase inhibitors are neuroprotective and preserve NGF-mediated cell survival following traumatic brain injury

21 January 2018

1 reference

The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system.

21 January 2018

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Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)

21 January 2018

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Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation

21 January 2018

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Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

21 January 2018

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Production of superoxide anions by a CNS macrophage, the microglia.

21 January 2018

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Activation of murine microglial cell lines by lipopolysaccharide and interferon-gamma causes NO-mediated decreases in mitochondrial and cellular function.

21 January 2018

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Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection

21 January 2018

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Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition

21 January 2018

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Valproic acid promotes neuronal differentiation by induction of proneural factors in association with H4 acetylation

21 January 2018

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Valproic acid induces differentiation and inhibition of proliferation in neural progenitor cells via the beta-catenin-Ras-ERK-p21Cip/WAF1 pathway

21 January 2018

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Neural stem cells for spinal cord repair.

21 January 2018

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Differentiation of engrafted neuronal-restricted precursor cells is inhibited in the traumatically injured spinal cord

21 January 2018

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Mechanisms of neural stem cell fate determination: extracellular cues and intracellular programs

21 January 2018

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Histone deacetylase inhibitors as therapeutic agents for acute central nervous system injuries

21 January 2018

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HDAC inhibition promotes neuronal outgrowth and counteracts growth cone collapse through CBP/p300 and P/CAF-dependent p53 acetylation

21 January 2018

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The mood stabilizer valproic acid activates mitogen-activated protein kinases and promotes neurite growth

21 January 2018

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Neurotrophin signalling and transcription programmes interactions in the development of somatosensory neurons

21 January 2018

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21 January 2018

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The Wnt/beta-catenin signaling pathway as a target in drug discovery

21 January 2018

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The glamour and gloom of glycogen synthase kinase-3

21 January 2018

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Mode of action: inhibition of histone deacetylase, altering WNT-dependent gene expression, and regulation of beta-catenin--developmental effects of valproic acid

21 January 2018

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Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors

21 January 2018

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Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis.

21 January 2018

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WNTs in the vertebrate nervous system: from patterning to neuronal connectivity

21 January 2018

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Neurogenesis and neuroprotection in the CNS--fundamental elements in the effect of Glatiramer acetate on treatment of autoimmune neurological disorders

21 January 2018

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Profile of spinal injuries in Lagos, Nigeria

21 January 2018

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Changes occur in the ability to promote axonal regeneration as the post-injury period increases.

21 January 2018

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Guidelines for the conduct of clinical trials for spinal cord injury (SCI) as developed by the ICCP panel: clinical trial outcome measures

21 January 2018

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Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: clinical trial design

21 January 2018

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Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP Panel: clinical trial inclusion/exclusion criteria and ethics

21 January 2018

1 reference

Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials

21 January 2018

1 reference

The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/RME.14.86

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25485637%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

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