The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology (Q38282318)

1 September 2017

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title

The GAD65 knock out mouse - a model for GABAergic processes in fear- and stress-induced psychopathology (English)

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1 September 2017

Iris Müller

1

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1 September 2017

Gürsel Çalışkan

series ordinal

2

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1 September 2017

Oliver Stork

series ordinal

3

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1 September 2017

language of work or name

English

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publication date

1 January 2015

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Genes, Brain and Behavior

1 September 2017

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1 September 2017

14

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1 September 2017

1

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1 September 2017

37-45

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Mice lacking the 65 kDa isoform of glutamic acid decarboxylase (GAD65) maintain normal levels of GAD67 and GABA in their brains but are susceptible to seizures

1 September 2017

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Cleft palate and decreased brain gamma-aminobutyric acid in mice lacking the 67-kDa isoform of glutamic acid decarboxylase

21 January 2018

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Effects of early-life stress on behavior and neurosteroid levels in the rat hypothalamus and entorhinal cortex.

21 January 2018

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Footshock intensity and generalization in contextual and auditory-cued fear conditioning in the rat.

21 January 2018

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Pre-pubertal stress exposure affects adult behavioral response in association with changes in circulating corticosterone and brain-derived neurotrophic factor.

21 January 2018

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The GABA-synthetic enzyme GAD65 controls circadian activation of conditioned fear pathways

21 January 2018

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Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory

21 January 2018

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Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic.

21 January 2018

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Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries

21 January 2018

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Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice.

21 January 2018

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Escape behavior produced by the blockade of glutamic acid decarboxylase (GAD) in mesencephalic central gray or medial hypothalamus

21 January 2018

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GABA/benzodiazepine receptors in the ventromedial hypothalamic nucleus regulate both anxiety and panic-related defensive responses in the elevated T-maze

21 January 2018

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Maternal behavior regulates benzodiazepine/GABAA receptor subunit expression in brain regions associated with fear in BALB/c and C57BL/6 mice

21 January 2018

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Contextual learning induces an increase in the number of hippocampal CA1 neurons expressing high levels of BDNF.

21 January 2018

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Childhood sexual abuse and psychiatric disorders in middle-aged and older adults: evidence from the 2007 Adult Psychiatric Morbidity Survey.

21 January 2018

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Membrane anchoring of the autoantigen GAD65 to microvesicles in pancreatic beta-cells by palmitoylation in the NH2-terminal domain

21 January 2018

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Decreased GABAA-receptor clustering results in enhanced anxiety and a bias for threat cues.

21 January 2018

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Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features

21 January 2018

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Combination of prenatal immune challenge and restraint stress affects prepulse inhibition and dopaminergic/GABAergic markers

21 January 2018

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Enduring psychobiological effects of childhood adversity

21 January 2018

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Sustained stress-induced changes in mice as a model for chronic depression

21 January 2018

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Two genes encode distinct glutamate decarboxylases

21 January 2018

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GABA(A) ρ receptor mechanisms in the rat amygdala and its role in the modulation of fear and anxiety

21 January 2018

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Stability of recent and remote contextual fear memory

21 January 2018

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Distribution of seizure precipitants among epilepsy syndromes

21 January 2018

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Increased vulnerability to depressive-like behavior of mice with decreased expression of VGLUT1.

21 January 2018

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Chronic stress induces changes in the structure of interneurons and in the expression of molecules related to neuronal structural plasticity and inhibitory neurotransmission in the amygdala of adult mice.

21 January 2018

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Post-weaning social isolation rearing influences the expression of molecules related to inhibitory neurotransmission and structural plasticity in the amygdala of adult rats.

21 January 2018

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Sensory integration in mouse insular cortex reflects GABA circuit maturation

21 January 2018

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Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice.

21 January 2018

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Decrease in reelin and glutamic acid decarboxylase67 (GAD67) expression in schizophrenia and bipolar disorder: a postmortem brain study

21 January 2018

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Increasing CREB in the auditory thalamus enhances memory and generalization of auditory conditioned fear

21 January 2018

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Seizure occurrence: precipitants and prediction

21 January 2018

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Prepulse inhibition deficits in GAD65 knockout mice and the effect of antipsychotic treatment

21 January 2018

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In vivo knockdown of GAD67 in the amygdala disrupts fear extinction and the anxiolytic-like effect of diazepam in mice

21 January 2018

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Training-induced changes in the expression of GABAA-associated genes in the amygdala after the acquisition and extinction of Pavlovian fear

21 January 2018

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Local GABA circuit control of experience-dependent plasticity in developing visual cortex.

21 January 2018

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Association between glutamic acid decarboxylase genes and anxiety disorders, major depression, and neuroticism

21 January 2018

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Post-weaning to pre-pubertal ('juvenile') stress: a model of induced predisposition to stress-related disorders.

21 January 2018

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A decrease of reelin expression as a putative vulnerability factor in schizophrenia

21 January 2018

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Development of the GABA system in organotypic culture of hippocampal and cerebellar slices from a 67-kDa isoform of glutamic acid decarboxylase (GAD67)-deficient mice.

21 January 2018

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Behavioural anomalies in mice evoked by "Tokyo" disruption of the Vitamin D receptor gene

21 January 2018

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Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase

21 January 2018

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Increased anxiety and altered responses to anxiolytics in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase.

21 January 2018

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Two forms of the gamma-aminobutyric acid synthetic enzyme glutamate decarboxylase have distinct intraneuronal distributions and cofactor interactions.

21 January 2018

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Role of NPY Y1 receptor on acquisition, consolidation and extinction on contextual fear conditioning: dissociation between anxiety, locomotion and non-emotional memory behavior.

21 January 2018

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Glutamic acid decarboxylase 65: a link between GABAergic synaptic plasticity in the lateral amygdala and conditioned fear generalization

21 January 2018

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Generalisation of conditioned fear and its behavioural expression in mice.

21 January 2018

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Emotion circuits in the brain

21 January 2018

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Heroin addiction in African Americans: a hypothesis-driven association study

21 January 2018

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Down-regulation of dendritic spine and glutamic acid decarboxylase 67 expressions in the reelin haploinsufficient heterozygous reeler mouse

21 January 2018

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Decreased GABA levels in anterior cingulate cortex/medial prefrontal cortex in panic disorder

21 January 2018

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Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia.

21 January 2018

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Altered GABAergic and glutamatergic activity within the rat hippocampus and amygdala in rats subjected to repeated corticosterone administration but not restraint stress.

21 January 2018

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Calcium-permeable AMPA receptors mediate long-term potentiation in interneurons in the amygdala.

21 January 2018

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Neurobiology of Pavlovian fear conditioning.

21 January 2018

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Gabaergic modulation of the stress response in frontal cortex and amygdala

21 January 2018

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Traits of fear resistance and susceptibility in an advanced intercross line.

21 January 2018

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Mechanisms of fear extinction

21 January 2018

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Which seizure-precipitating factors do patients with epilepsy most frequently report?

21 January 2018

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Rats displaying distinct exploratory activity also have different expression patterns of gamma-aminobutyric acid- and cholecystokinin-related genes in brain regions.

21 January 2018

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PCP-induced deficits in murine nest building activity: employment of an ethological rodent behavior to mimic negative-like symptoms of schizophrenia.

21 January 2018

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The central and basolateral amygdala differentially mediate the anxiolytic effects of benzodiazepines.

21 January 2018

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Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning

21 January 2018

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Decreased corticolimbic allopregnanolone expression during social isolation enhances contextual fear: A model relevant for posttraumatic stress disorder

21 January 2018

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Modulation of GABAA receptor signaling increases neurogenesis and suppresses anxiety through NFATc4.

21 January 2018

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Prenatal immune activation induces maturation-dependent alterations in the prefrontal GABAergic transcriptome

21 January 2018

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Sodium lactate elicits anxiety in rats after repeated GABA receptor blockade in the basolateral amygdala.

21 January 2018

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Priming of experimental anxiety by repeated subthreshold GABA blockade in the rat amygdala.

21 January 2018

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Glutamic acid decarboxylase 67 haplodeficiency impairs social behavior in mice.

21 January 2018

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Differential regulation of glutamic acid decarboxylase gene expression after extinction of a recent memory vs. intermediate memory

21 January 2018

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Deficiency of the 65 kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory.

21 January 2018

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Gabaergic mechanisms of hypothalamic nuclei in the expression of conditioned fear

21 January 2018

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Hippocampal hyperexcitability underlies enhanced fear memories in TgNTRK3, a panic disorder mouse model.

21 January 2018

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Generalization of contextual fear depends on associative rather than non-associative memory components.

21 January 2018

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Phencyclidine-induced social withdrawal results from deficient stimulation of cannabinoid CB₁ receptors: implications for schizophrenia.

21 January 2018

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Intranasal neuropeptide Y reverses anxiety and depressive-like behavior impaired by single prolonged stress PTSD model

21 January 2018

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Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.

21 January 2018

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Regional distribution and relative amounts of glutamate decarboxylase isoforms in rat and mouse brain

21 January 2018

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Chronic stimulation of corticotropin-releasing factor receptor 1 enhances the anxiogenic response of the cholecystokinin system

21 January 2018

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Self-perception of seizure precipitants and their relation to anxiety level, depression, and health locus of control in epilepsy.

21 January 2018

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Postnatal development of a GABA deficit and disturbance of neural functions in mice lacking GAD65.

21 January 2018

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Altered conditioned fear behavior in glutamate decarboxylase 65 null mutant mice

21 January 2018

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The role of the synthetic enzyme GAD65 in the control of neuronal gamma-aminobutyric acid release

21 January 2018

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Exposure to stressors during juvenility disrupts development-related alterations in the PSA-NCAM to NCAM expression ratio: potential relevance for mood and anxiety disorders

21 January 2018

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Long-term behavioral programming induced by peripuberty stress in rats is accompanied by GABAergic-related alterations in the Amygdala.

21 January 2018

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Low posttrauma GABA plasma levels as a predictive factor in the development of acute posttraumatic stress disorder

21 January 2018

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Anatomical connections of the periaqueductal gray: specific neural substrates for different kinds of fear.

21 January 2018

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Schizophrenia: a neural diathesis-stress model

21 January 2018

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GAD65 is essential for synthesis of GABA destined for tonic inhibition regulating epileptiform activity

21 January 2018

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Gender differences in associations of glutamate decarboxylase 1 gene (GAD1) variants with panic disorder

21 January 2018

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Induction of panic attack by stimulation of the ventromedial hypothalamus.

21 January 2018

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Changes in neural network homeostasis trigger neuropsychiatric symptoms

21 January 2018

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Role of glutamate decarboxylase (GAD) isoform, GAD65, in GABA synthesis and transport into synaptic vesicles-Evidence from GAD65-knockout mice studies.

21 January 2018

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Response variation following trauma: a translational neuroscience approach to understanding PTSD.

21 January 2018

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Systematic study of association of four GABAergic genes: glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABA(B) receptor 1 gene and GABA(A) receptor subunit beta2 gene, with schizophrenia using a universal DNA microarray

21 January 2018

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Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice.

21 January 2018

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Post-traumatic stress disorder: facts and fiction

21 January 2018

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Mutation screen of theGAD2 gene and association study of alcoholism in three populations

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/GBB.12188

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1 September 2017

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