Afatinib: A first-line treatment for selected patients with metastatic non-small-cell lung cancer (Q38263148)

1 September 2017

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title

Afatinib: A first-line treatment for selected patients with metastatic non-small-cell lung cancer (English)

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1 September 2017

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Jeff A Engle

1

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PubMed ID

25349236

1 September 2017

Jill M Kolesar

series ordinal

2

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1 September 2017

1 November 2014

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American Journal of Health-System Pharmacy

1 September 2017

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1 September 2017

71

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1 September 2017

22

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1 September 2017

1933-1938

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1 September 2017

Cancer statistics, 2014

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https://api.crossref.org/works/10.2146%2FAJHP130654

2011 Focused Update of 2009 American Society of Clinical Oncology Clinical Practice Guideline Update on Chemotherapy for Stage IV Non-Small-Cell Lung Cancer

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Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial

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ERBB receptors and cancer: the complexity of targeted inhibitors

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EGFR-mutated oncogene-addicted non-small cell lung cancer: current trends and future prospects

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Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker

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BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models

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EGFR inhibitors in non-small cell lung cancer (NSCLC): the emerging role of the dual irreversible EGFR/HER2 inhibitor BIBW 2992.

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Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers.

31 March 2020

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Phase I trial of the irreversible EGFR and HER2 kinase inhibitor BIBW 2992 in patients with advanced solid tumors

31 March 2020

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Phase I study of continuous afatinib (BIBW 2992) in patients with advanced non-small cell lung cancer after prior chemotherapy/erlotinib/gefitinib (LUX-Lung 4).

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP130654

Afatinib versus placebo for patients with advanced, metastatic non-small-cell lung cancer after failure of erlotinib, gefitinib, or both, and one or two lines of chemotherapy (LUX-Lung 1): a phase 2b/3 randomised trial

31 March 2020

1 reference

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LUX-Lung 4: a phase II trial of afatinib in patients with advanced non-small-cell lung cancer who progressed during prior treatment with erlotinib, gefitinib, or both

31 March 2020

1 reference

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Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations.

31 March 2020

1 reference

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Symptom control and quality of life in LUX-Lung 3: a phase III study of afatinib or cisplatin/pemetrexed in patients with advanced lung adenocarcinoma with EGFR mutations.

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1 reference

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A Phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors

31 March 2020

1 reference

https://api.crossref.org/works/10.2146%2FAJHP130654

31 March 2020

Identifiers

DOI

10.2146/AJHP130654

1 reference

1 September 2017

1 reference

PubMed ID

25349236