Sirtuins and the circadian clock: bridging chromatin and metabolism (Q38247938)

1 September 2017

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title

Sirtuins and the circadian clock: bridging chromatin and metabolism (English)

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1 September 2017

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2

Paolo Sassone-Corsi

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1 September 2017

Selma Masri

1

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1 September 2017

9 September 2014

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1 September 2017

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1 September 2017

7

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1 September 2017

re6

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1 September 2017

342

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Regulation of metabolism: the circadian clock dictates the time

1 September 2017

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian topology of metabolism

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

A web of circadian pacemakers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Suprachiasmatic nucleus: cell autonomy and network properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian cycling of the mouse liver transcriptome, as revealed by cDNA microarray, is driven by the suprachiasmatic nucleus.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Coordinated transcription of key pathways in the mouse by the circadian clock

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Plasticity and specificity of the circadian epigenome

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Nuclear receptor expression links the circadian clock to metabolism

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

A positive role for PERIOD in mammalian circadian gene expression

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Recent progress in the biology and physiology of sirtuins

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The sirtuin family's role in aging and age-associated pathologies

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Mammalian sirtuins: biological insights and disease relevance

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT1 and other sirtuins in metabolism

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Regulation of sirtuin function by posttranslational modifications

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

CLOCK-mediated acetylation of BMAL1 controls circadian function

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Sirtuins: guardians of mammalian healthspan

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The many faces of sirtuins: Coupling of NAD metabolism, sirtuins and lifespan

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Dynamic chromatin localization of Sirt6 shapes stress- and aging-related transcriptional networks.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Chromatin regulation and genome maintenance by mammalian SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Chromatin and beyond: the multitasking roles for SIRT6

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT6 exhibits nucleosome-dependent deacetylase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The human circadian metabolome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Coordination of the transcriptome and metabolome by the circadian clock

21 January 2018

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https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Measurement of internal body time by blood metabolomics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Relationship between calorie restriction and the biological clock: lessons from long-lived transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Altered behavioral and metabolic circadian rhythms in mice with disrupted NAD+ oscillation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Activation of the protein deacetylase SIRT6 by long-chain fatty acids and widespread deacylation by mammalian sirtuins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Circadian control of fatty acid elongation by SIRT1 protein-mediated deacetylation of acetyl-coenzyme A synthetase 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Pharmacological modulation of circadian rhythms by synthetic activators of the deacetylase SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Tissue-specific regulation of SIRT1 by calorie restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Regulation of SIRT6 protein levels by nutrient availability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Sirt1 protects against high-fat diet-induced metabolic damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT6 protects against pathological damage caused by diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Reprogramming of the circadian clock by nutritional challenge.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

High-fat diet disrupts behavioral and molecular circadian rhythms in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

The circadian clock coordinates ribosome biogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2005685

10.1126/SCISIGNAL.2005685

21 January 2018

Identifiers

DOI

1 reference

1 September 2017

1 reference

PubMed ID

25205852